Synthesis, spectral characterization, electrochemical, anti-microbial, DNA binding and cleavage studies of new binuclear Schiff base metal(II) complexes derived from o-hydroxyacetophenone

Synthesis, structural characterization and biological properties of Cu(II), Ni(II), Mn(II), Zn(II) and VO(II) complexes of tetradentate Schiff bases

“…In Figure 5 and 6, the lane 1, 2 did not show any significant cleavage whereas from lane 3-7 shows the significant cleavage of DNA in presence of H2O2 [34]. …”

Vanadium: Risks and possible benefits in the light of a comprehensive overview of its pharmacotoxicological mechanisms and multi-applications with a summary of further research trends

“…11) along with induction of potassium (K + ) outflow from the cell [137], (d) interaction with topoisomerase type II (gyrase) ( Fig. 11), which is necessary for the proper functioning of the genome and bacterial growth, with the ATP-binding site used as a target for antibacterial drugs [144,145], (e) interaction with DNA in an intercalative manner [133] resulting in modification of the DNA structure (unwinding, stiffening, and elongation of the double helix) with formation of an intercalative complex [146], (f) interaction with components of the cytoskeleton, which results in morphological alterations of bacterial cells thereby preventing proper division [137], and (g) other nonspecific mechanisms of action ( Fig. 11), with emphasis on the better bioavailability of V complexes due to the presence of a specific ligand allowing the complex to penetrate the hydrophobic lipid-rich bacteria wall [acc.…”

“…Among the mechanisms of the anti-fungal activity of V complexes which, likewise the mechanisms of the anti-bacterial and anti-viral activity of this metal have not been fully recognized yet, interactions with DNA by intercalation have been proposed [133]. Additionally, inhibition of biosynthesis of an important component of the fungal cell membrane, i.e.…”

“…Vanadium against certain viruses, bacteria, parasites, and fungi. Based on available literature data[26,33,39,45,[124][125][126][127][128][129][130][131][132][133][134][135][136][137].…”

Synthesis, Characterization and Antibacterial Activity of 1,4-di[ aminomethylene carboxyl] phenylene (H2L) and its Complexes Co(II), Cu (II), Zn(II) and Cd (II)

“…Chelating ligands containg O and N donor atoms show broad biological activity and are special interest because of the variety of ways in which they are bonded metal ions [2,[3][4][5][6][7][8]. It is well known Schiff bases complexes have numerous applications, such as in the treatment cancer [9], as antibactericide agents and as antifungicide agents [10,11]. Recently one of our group research has studied mixed ligand (1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1 H-pyrazol-4-ylimino) and azide ion forming complexes with Mn(II), Co(II), Ni(II), Zn(II), Cd(II) and Hg(II) ion [12].…”