Synthesis, ¹³C‐NMR characterization and antimicrobial properties of a novel series of 3‐(N‐Substituted thiocarbamoyl)hydrazino‐1,2,4‐triazino‐[5,6‐b]indole derivatives

Abstract

A series of 3‐(N‐substituted thiocarbamoyl)hydrazino‐1,2,4‐triazino[5,6‐b]indole derivatives 3–22 has been synthesized and evaluated for in vitro antimicrobial activity. Although some of the products displayed significant activity against Staphylococcus aureus, Escherichia coli and Candida albicans, their bactericidal and bacterostatic potencies were lower than that of penicillin G. The structure of the products was assigned upon the basis of their infrared, 1H‐nmr and 13C‐nmr spectra.

Synthesis and spectral studies on metal complexes of s-triazine based ligand and non linear optical properties

“…3). The molecular ion peak for the cobalt(II) complex (6), observed at m/z 849 confirms the stoichiometry of metal complexes as [M(L) 2 ]Cl 2 .…”

“…obtained is the normal range of octahedral symmetry [36]. The electronic absorption spectrum of cobalt(II) complex (6) gives absorption bands at 9569, 16,260, 21,413 cm À1 due to ( 4 T 1g (F) ? 4 T 2g (F), 4 T 1g (F) ?…”

“…S-triazine and its derivatives, quite known, come with a broad spectrum of pharmacological advantages: anti-bacterial, anti-viral, anti-malarial, anti-inflammatory and promising recently, anticancer, anti-leukemia and anti-HIV activities [1][2][3][4][5][6]. Several triazine analogues are utilized as a building block for the construction of multisite ligand systems [7,8].…”

Double-headed nucleosides: Synthesis and applications

“…The double-headed nucleosides 222 and 223a-f were synthesized with the aim to evaluate their biological activities due to the potent inhibitory effect of the precursor 4-amino-5mercapto-1,2,4-triazole against glycosidase enzymes [17,[91][92][93]. The synthesized double-headed nucleosides 226-231 were expected to possess potent biological activities due to the known antimicrobial [94][95][96][97][98], antiviral [99], antihypertensive [99,100], analgesic [101], and antitumor activities [102] exhibited by various derivatives of 1,2,4-triazino [5,6-b]indole [18].…”