Synthetic biodegradable medical polymer

Ghadi, Rohan; Muntimadugu, Eameema; Domb, Abraham J.; Khan, Wahid; Zhang, X.

doi:10.1016/b978-0-08-100372-5.00005-2

Cited by 15 publications

(35 citation statements)

References 110 publications

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“…Polyanhydrides represent an important class of polymers that has been used for medical purposes including encapsulation of drugs in nanoparticles [11][12][13]. They can be prepared easily from available, low-cost resources and can be manipulated to meet markers for bioimaging and sensing devices and have recently been used to develop multicolor fluorescent liposomal nanoparticles activated by temperature, capable of being excited at the same wavelength [35][36][37][38][39][40][41].…”

Section: Introductionmentioning

confidence: 99%

Formation of Multicolor Nanogels Based on Cationic Polyfluorenes and Poly(methyl vinyl ether-alt-maleic monoethyl ester): Potential Use as pH-Responsive Fluorescent Drug Carriers

Rubio-Camacho

Martínez-Tomé

Mira

et al. 2021

IJMS

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In this study, we employed the copolymer poly(methyl vinyl ether-alt-maleic monoethyl ester) (PMVEMA-Es) and three fluorene-based cationic conjugated polyelectrolytes to develop fluorescent nanoparticles with emission in the blue, green and red spectral regions. The size, Zeta Potential, polydispersity, morphology, time-stability and fluorescent properties of these nanoparticles were characterized, as well as the nature of the interaction between both PMVEMA-Es and fluorescent polyelectrolytes. Because PMVEMA-Es contains a carboxylic acid group in its structure, the effects of pH and ionic strength on the nanoparticles were also evaluated, finding that the size is responsive to pH and ionic strength, largely swelling at physiological pH and returning to their initial size at acidic pHs. Thus, the developed fluorescent nanoparticles can be categorized as pH-sensitive fluorescent nanogels, since they possess the properties of both pH-responsive hydrogels and nanoparticulate systems. Doxorubicin (DOX) was used as a model drug to show the capacity of the blue-emitting nanogels to hold drugs in acidic media and release them at physiological pH, from changes in the fluorescence properties of both nanoparticles and DOX. In addition, preliminary studies by super-resolution confocal microscopy were performed, regarding their potential use as image probes.

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Section: Introductionmentioning

confidence: 99%

Formation of Multicolor Nanogels Based on Cationic Polyfluorenes and Poly(methyl vinyl ether-alt-maleic monoethyl ester): Potential Use as pH-Responsive Fluorescent Drug Carriers

Rubio-Camacho

Martínez-Tomé

Mira

et al. 2021

IJMS

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“…These sustainable nanofibers have been used for controlled drug delivery systems. [132][133][134][135] Aliphatic polycarbonates are biodegradable polymers but have insufficient compatibility, high hydrophobicity, and less functionality. Hence, they have been used in limited medical applications due to their less appealing properties.…”

Section: Polyanhydrides and Polycarbonatesmentioning

confidence: 99%

Sustainable nanofibers in tissue engineering and biomedical applications

Malik

Sundarrajan

Hussain

et al. 2020

Mat Design & Process Comms

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The practice of using a massive amount of environmental unfriendly and toxic petroleum-based materials in tissue engineering and biomedical fields demands the materials, which are biodegradable, renewable, environmentally friendly, biocompatible, and bioactive. So, renewable polymers have got considerable attention due to their numerous desirable properties. The nanofibers that are prepared from renewable materials and their blends can integrate the properties of both nanofibers and renewable polymers. Development of scaffolds that mimic the construction of tissues at nanoscale is a great challenge for tissue engineering. Electrospinning is the most promising technique for nanofibers formation. Nanofibers provide a platform for cell adhesion, proliferation, and differentiation. Therefore, nanofibers from sustainable materials have been used in tissue engineering and biomedical fields. In this review, methods for nanofibers fabrication, sustainable nanofibers made from natural and synthetic polymers and their applications in tissue engineering and biomedical field, have been emphasized.

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“…O sistema de transporte desses polianidridos também se divide em dois tipos: particulados (são as microesferas e as nanopartículas) e a matriz (são os implantes, filmes, pasta cirúrgica, folhas). Já o seu mecanismo de degradação se dá pela erosão superficial (GHADI, et al, 2017).…”

Section: Classificaçao Do Polianidridounclassified

“…Uma variedade de polímeros biodegradáveis e biocompatíveis são sintetizados por métodos químicos (BALAJI et al, 2018). Os polianidridos são sintetizados usando vários métodos, como policondensação por fusão, polimerização em solução, polimerização por abertura de anel (ROP) (GHADI et al, 2017), condensação interfacial, desidrocloração e acoplamento desidratante. Além disso deve-se atentar a subprodutos no final da polimerização que tem que ser retirados por lavagem com solventes próticos (BALAJI et al, 2018;EAMEEAMA, et al, 2014), como verificamos na Figura 2.…”

Section: Sintese Para a Formação Do Polianidrido (Pa)unclassified

“…Atualmente, são usados principalmente na indústria de dispositivos médicos e farmacêutica (McKeen, 2017). Os polianidridos como já mencionado, são biopolimeros, que já têm sido amplamente explorados para serem usados como transportadores de medicamentos para vários órgãos do corpo humano (GHADI et al, 2017). Estes foram investigados para liberação controlada de medicamentos para tratamento de distúrbios oculares e também para administração de agentes anti-neoplásicos, anestésicos locais, anticoagulantes, drogas neuroativas, antibióticos, vacinas e proteínas e são protegidos quando carregados pois a maioria da água não penetra até que o polímero chegue ao alvo (PRAJAPATI et al, 2019).…”

Section: Introductionunclassified

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Adsorção De Íons Cádmio Por Derivados Carboximetilados E Sulfatados De Quitosana

Almeida¹,

Lima²,

Coelho³

et al. 2020

A Química Nas Áreas Natural, Tecnológica E Sustentável

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Direitos para esta edição cedidos à Atena Editora pelos autores.Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.A Atena Editora não se responsabiliza por eventuais mudanças ocorridas nos endereços convencionais ou eletrônicos citados nesta obra.Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação.

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Synthetic biodegradable medical polymer

Cited by 15 publications

References 110 publications

Formation of Multicolor Nanogels Based on Cationic Polyfluorenes and Poly(methyl vinyl ether-alt-maleic monoethyl ester): Potential Use as pH-Responsive Fluorescent Drug Carriers

Formation of Multicolor Nanogels Based on Cationic Polyfluorenes and Poly(methyl vinyl ether-alt-maleic monoethyl ester): Potential Use as pH-Responsive Fluorescent Drug Carriers

Sustainable nanofibers in tissue engineering and biomedical applications

Adsorção De Íons Cádmio Por Derivados Carboximetilados E Sulfatados De Quitosana

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