Tailor-Engineered POSS-Based Hybrid Gels for Bone Regeneration

Lu, Nana; Lu, Yingxi; Liu, Shengsen; Jin, Chuanyu; Fang, Sha; Zhou, Xianfeng; Li, Zhibo

doi:10.1021/acs.biomac.9b00771

Cited by 23 publications

(15 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The implantation operation was performed according to the previously reported procedure. [ 26 ] In the experimental groups, nanofiber membranes were implanted into subcutaneous pocket of each mouse. The skin was closed with continuous intracutaneous 4‐0 Vicryl sutures.…”

Section: Methodsmentioning

confidence: 99%

Robust Electrospun Nanofibers from Chemosynthetic Poly(4‐hydroxybutyrate) as Artificial Dural Substitute

Sun

Tang

et al. 2021

Macromolecular Bioscience

Self Cite

View full text Add to dashboard Cite

Bioresorbable poly(4-hydroxybutyrate) (P4HB) may fulfill the specific requirements that are necessary for a dural substitute, including its high elasticity, long-term strength retention properties, and the biocompatibility without significant accumulation of acidic degradation products. However, commercial P4HB can only be produced by the bacterial fermentation, which limits its applications in the cerebrospinal system due to higher endotoxin restriction. Meanwhile, P4HB can be prepared via the ring-opening polymerization of -butyrolactone. In this contribution, high molecular weight P4HB from chemosynthesis is electrospun into fibrous membrane, showing good mechanical properties that match the natural dura mater. Such P4HB membrane induces fast cellular migration, adhesion, and proliferation of fibroblasts in vitro. Subcutaneous implantation in rats demonstrates excellent biocompatibility of the P4HB membrane with proper biodegradation behaviors. After implantation in the rabbit dural defect model as an onlay graft, the P4HB membranes prevent cerebrospinal fluid leakage and regenerate dura tissue without detecting any local or systematic infections or foreign body responses. Thus, the electrospun P4HB membranes may be particularly useful as artificial dural substitutes to induce wound closure and tissue regeneration, which will be of great benefit to neurosurgery in the future.

show abstract

Section: Methodsmentioning

confidence: 99%

Robust Electrospun Nanofibers from Chemosynthetic Poly(4‐hydroxybutyrate) as Artificial Dural Substitute

Sun

Tang

et al. 2021

Macromolecular Bioscience

Self Cite

View full text Add to dashboard Cite

show abstract

“…reported a kind of OEG n −POSS hybrid materials by weaving into macroscopically shaped entities via thiol−ene chemistry. [ 137 ] By tailoring the molecular weight of OEG, the mechanical behavior and interfacial nature of OEG n −POSS were customized with excellent bioactivity to form hydroxyapatite. Despite the limitation of mismatch rates between the degradation and new bone formation, OEG 2 −POSS materials enhanced in vitro differentiation of adipose‐derived stem cells to osteoblasts and promoted the in vivo bone formation within a femoral condyle defect site, which would of be great benefit for bone regeneration by optimizing structural features and matching the degradation rate in the future.…”

Section: Biomedical Application Of Poss‐based Hybrid Materialsmentioning

confidence: 99%

Polyhedral Oligomeric Silsesquioxanes (POSS)‐based Hybrid Materials: Molecular Design, Solution Self‐Assembly and Biomedical Applications

Fan

Wang

2021

Chin. J. Chem.

View full text Add to dashboard Cite

Owing to the tremendous advantages and unique well‐defined nanoscale structure, polyhedral oligomeric silsesquioxanes (POSS) have received considerable interest in the design of novel organic‐inorganic hybrid nanomaterials with all manner of prominent capabilities, which is recognized as a new generation of promising materials for advanced applications of material science, engineering science and biomedical fields. Benefitting from the recent progress in combination of controlled/living polymerization and emerging click chemistry, POSS‐based hybrid materials with ingenious design, versatile topological structure and sophisticated multifunctionality have been successfully fabricated and developed into abundant well‐defined hybrid nanostructures with desired physicochemical properties. Tailor‐made amphiphilic molecular design and nanosized hybrid architecture provide opportunities for the self‐assembly of POSS‐based hybrid materials with unique hierarchical morphologies in selective solvents. Through the in‐depth understanding of structure‐properties relationship, POSS‐based hybrid materials can achieve the modulation of precise control of self‐assembling process and multi‐purpose applications with improved material performances. In this review, we summarize the recent advances of POSS‐based hybrid materials in molecular design, self‐assembly behavior in solutions and potential biomedical applications with main concerns on drug delivery, gene therapy, bioimaging and tissue engineering field. Finally, future directions and remaining challenges for further advancement of POSS‐based hybrid materials are proposed and discussed.

show abstract

“…[5,6]. Although substantial progress has been made in developing inorganic-organic hybrids that mimic natural materials [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23], challenges still remain; among others, the inorganic nanocomponents are not homogenously intercalated with the organic part, limiting the content of inorganic phase and the resultant properties [24,25]. To address this issue, significant effort has been made.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic tissue regenerative nanohybrids self-assembled from bioactive inorganic core / chitosan shell nanounits

Kim

Lee²,

Mandakhbayar

et al. 2021

Biomaterials

View full text Add to dashboard Cite

Tailor-Engineered POSS-Based Hybrid Gels for Bone Regeneration

Cited by 23 publications

References 34 publications

Robust Electrospun Nanofibers from Chemosynthetic Poly(4‐hydroxybutyrate) as Artificial Dural Substitute

Robust Electrospun Nanofibers from Chemosynthetic Poly(4‐hydroxybutyrate) as Artificial Dural Substitute

Polyhedral Oligomeric Silsesquioxanes (POSS)‐based Hybrid Materials: Molecular Design, Solution Self‐Assembly and Biomedical Applications

Therapeutic tissue regenerative nanohybrids self-assembled from bioactive inorganic core / chitosan shell nanounits

Contact Info

Product

Resources

About