Targeted and non-targeted analysis of young-of-year smallmouth bass using comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry

Recent Advances in GC×GC and Chemometrics to Address Emerging Challenges in Nontargeted Analysis

“…Similar to the exemplary work shown in Figure B, Purcaro et al utilized peak table-based FRA to discover 16 analytes that differentiated cells infected by respiratory syncytial virus . Furthermore, Dorman and co-workers have recently used FRA to discover dozens of compounds correlated to the declining health of smallmouth bass in polluted river basins. , Regarding food studies, peak table-based FRA was also employed to discover differences in wines based on grape maturity, vine management, and maceration times. , Perrault et al also utilized peak table-based FRA on data collected with GC×GC-HRMS to differentiate the volatile signature of adhesives commonly used for archeological artifacts …”

Cracked and Shucked: Gc-Apci-Ims-Hrms Facilitates Identification of Unknown Halogenated Organic Chemicals in French Marine Bivalves

“…Instrumental innovations over the last decade alongside the increasing availability of open science tools and databases, has enabled the development of techniques that allow scientists to characterize chemical space to an extent that was previously onerous. Improvements in the mass accuracy, mass spectral acquisition speed, mass resolving power, sensitivity of HRMS instruments, and resolution of different chromatographic techniques enabled the detection of bioaccumulative chemicals in bivalves (Goto et al, 2020), fish and reptiles (Teehan et al, 2022;Renaguli et al, 2021), and marine mammals. (Hoh et al, 2012;Alonso et al, 2017;Cossaboon et al, 2019;Cariou et al, 2021) Using these capabilities, the mass spectrometry community have improved our ability to translate mass-to-charge data into chemical information including unambiguous chemical formula assignments and structural annotation elucidation.…”