Technological Excipients of Tablets: Study of Flow Properties and Compaction Behavior

Conceição, Jaime; Estanqueiro, Marilene; Amaral, Maria Helena; Silva, J. P.; Lobo, José Manuel Sousa

doi:10.12691/ajmsm-2-4-2

Cited by 7 publications

(5 citation statements)

References 23 publications

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“…Each of the D-Sorbitol used in the formulation had different particle sizes and shapes. These characteristics induce changes in flow properties [ 51 ]. Flowability was an important bulk powder characteristic.…”

Section: Resultsmentioning

confidence: 99%

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D-Sorbitol Physical Properties Effects on Filaments Used by 3D Printing Process for Personalized Medicine

et al. 2021

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Fused filament fabrication (FFF) is a process used to manufacture oral forms adapted to the needs of patients. Polyethylene oxide (PEO) filaments were produced by hot melt extrusion (HME) to obtain a filament suitable for the production of amiodarone hydrochloride oral forms by FFF 3D printing. In order to produce personalized oral forms adapted to the patient characteristics, filaments used by FFF must be controlled in terms of mass homogeneity along filament. This work highlights the relation between filament mass homogeneity and its diameter. This is why the impact of filler excipients physical properties was studied. It has been showed that the particle’s size distribution of the filler can modify the filament diameter variability which has had an impact on the mass of oral forms produced by FFF. Through this work it was shown that D-Sorbitol from Carlo Erba allows to obtain a diameter variability of less than 2% due to its unique particle’s size distribution. Using the filament produced by HME and an innovating calibration method based on the filament length, it has been possible to carry out three dosages of 125 mg, 750 mg and 1000 mg by 3D printing with acceptable mass uniformity.

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Section: Resultsmentioning

confidence: 99%

“…Flowability was an important bulk powder characteristic. Angle of repose, Carr’s index, Hausner ratio were used to express powders flowability [ 51 , 52 ].…”

Section: Resultsmentioning

confidence: 99%

D-Sorbitol Physical Properties Effects on Filaments Used by 3D Printing Process for Personalized Medicine

et al. 2021

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“…The slope of the cliff varied from 40° to 65°. Such an angle of repose suggests a rather strong cohesive energy between bacteria in the mother colony implying very poor flow characteristics ( 42 , 43 ). The increased cohesive energy of biofilm grown on 6% agar has been experimentally verified ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Mechanical constraints to unbound expansion of B. subtilis on semi-solid surfaces

Krajnc,

Fei,

Košmrlj

et al. 2024

Microbiol Spectr

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The effects of surface mechanical constraints that may promote or prevent bacterial expansion on semi-solid surfaces are largely unknown. In this work, we have manufactured agar surfaces with different viscoelasticity, topography, and roughness. To capture the essential biophysics of the bacterial expansion we have developed a continuum model that faithfully reproduces the main patterns of the short-range and long-range expansion with two critical parameters: local interfacial forces and colony viscosity. Cohesive energy of the bacterial colony that determines the extent of exploration was dependent on agar surface viscoelasticity. On soft surfaces, bacteria produce low viscoelastic colonies that allow guided population of bacteria to traverse distances that are six orders of magnitude larger than the size of the individual bacterium. Bacteria growing on stiff surfaces produce colonies with significantly increased viscoelasticity that prevent bacterial exploration of new territory and allow formation of a very steep cliff at the edge of the colony. Upon flooding of the rough surfaces, we have induced aquaplaning and spreading of bacteria. A layer of water between the bacterium and surface results in a loss of traction allowing bacteria to spread across the otherwise inhibitory rough surface. The results shed new light on the bacterial ability to rapidly colonize new territories. IMPORTANCE How bacterial cells colonize new territory is a problem of fundamental microbiological and biophysical interest and is key to the emergence of several phenomena of biological, ecological, and medical relevance. Here, we demonstrate how bacteria stuck in a colony of finite size can resume exploration of new territory by aquaplaning and how they fine tune biofilm viscoelasticity to surface material properties that allows them differential mobility. We show how changing local interfacial forces and colony viscosity results in a plethora of bacterial morphologies on surfaces with different physical and mechanical properties.

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“…The co-processed excipient obtained showed no influence of mixing consolidation times; these results are consistent for materials that present fragmentable behavior. Various authors [ 26 , 37 , 38 ] have described the brittle behavior of compacted dibasic calcium phosphate dihydrate. Almaya et al [ 37 ], for instance, determined that viscoelastic and deformed plastic materials were more sensitive to the addition of a lubricant than brittle materials, suggesting that tensile strength was independent of the addition of a lubricant and of the lubricant mixing time.…”

Section: Resultsmentioning

confidence: 99%

Preparation of Co-Processed Excipients for Controlled-Release of Drugs Assembled with Solid Lipid Nanoparticles and Direct Compression Materials

et al. 2021

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The purpose of the study was to develop a novel, directly compressible, co-processed excipient capable of providing a controlled-release drug system for the pharmaceutical industry. A co-processed powder was formed by adsorption of solid lipid nanoparticles (SLN) as a controlled-release film onto a functional excipient, in this case, dicalcium phosphate dihydrate (DPD), for direct compression (Di-Tab®). The co-processed excipient has advantages: easy to implement; solvent-free; industrial scaling-up; good rheological and compressibility properties; and the capability to form an inert platform. Six different batches of Di-Tab®:SLN weight ratios were prepared (4:0.6, 3:0.6, 2:0.6, 1:0.6, 0.5:0.6, and 0.25:0.6). BCS class III ranitidine hydrochloride was selected as a drug model to evaluate the mixture’s controlled-release capabilities. The co-processed excipients were characterized in terms of powder rheology and dissolution rate. The best Di-Tab®:SLN ratio proved to be 2:0.6, as it showed high functionality with good flow and compressibility properties (Carr Index = 16 ± 1, Hausner Index = 1.19 ± 0.04). This ratio could control release for up to 8 h, so it fits the ideal profile calculated based on biopharmaceutical data. The compressed systems obtained using this powder mixture behave as a matrix platform in which Fickian diffusion governs the release. The Higuchi model can explain their behavior.

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Technological Excipients of Tablets: Study of Flow Properties and Compaction Behavior

Cited by 7 publications

References 23 publications

D-Sorbitol Physical Properties Effects on Filaments Used by 3D Printing Process for Personalized Medicine

D-Sorbitol Physical Properties Effects on Filaments Used by 3D Printing Process for Personalized Medicine

Mechanical constraints to unbound expansion of B. subtilis on semi-solid surfaces

Preparation of Co-Processed Excipients for Controlled-Release of Drugs Assembled with Solid Lipid Nanoparticles and Direct Compression Materials

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