“…Even higher TDTs, sufficient to differentiate from Parkinson patients, were reported in multiple system atrophy (Rocchi et al, 2013). In dystonia, increased TDT (Conte et al, 2014b, Bradley et al, 2012, Scontrini et al, 2009, Fiorio et al, 2008a, Fiorio et al, 2003, Sanger, et al, 2001, Bara-Jimenez, et al, 2000, Tinazzi et al, 1999) is not only prevalent, but considered to be an endophenotype in autosomal dominant primary torsion dystonia, seen even in unaffected carriers (Kimmich et al, 2011, Bradley et al, 2009, Fiorio et al, 2007). That TDT is highly associated with particular gene mutations has led to interest in developing TDT as a useful tool in performing genetic studies.…”