Terapi Hiperkolesterol pada Mencit (Mus musculus) strain Balb/C Betina Umur 2 Bulan Menggunakan Sari Bawang Putih

Abstract

Cholesterol is a waxy substance which is mainly made in the body. Cholesterol can provide benefits. However, having too much cholesterol in the blood can increase risk of cardiovascular disease. Prevention and treatment of cardiovascular disease can be done by taking synthetic drugs such as statin. Due to side effects of synthetic drugs, it is necessary to substitute synthetic drugs with herbal plant and some natural component in these plants. The important ones is garlic. Garlic contain organosulphur compounds such as diallyldisulphide (DADS), dipropyldisulphide (DPDS), diallytrisulphide (DATS) and dipropyltrisulphide (DPTS) which have anti artherogenic effects. Garlic also have active agent allicin, can reduce the levels of cholesterol. This research was conducted at the Experimental Animal Enclosure Installation, Center for Veterinary Farma Surabaya with 3 experimental groups. Animals used in this research were female mice 2 months old were feeding with high cholesterol feed such as fried offal of chicken twice a day as much 0,5 cc/ day every 3 days. On the 3rd day, the levels of cholesterol in each group was examined. On the 4th day, mice in group 3 were given 1cc of garlic juice. 1 hour later mice was examined blood cholesterol using Strip Test Easy Touch GCU. The results through T-paired test on SPSS stated that (p < 0,05), it means there is influence between the 3 treatment of mice. This results it can be concluded that the provision of garlic juice can reduced blood cholesterol levels in mice after fed with high cholesterol.

Pengaruh Ekstrak Etanol Bawang Putih Tunggal (Allium sativum L.) Terhadap Kadar Kolesterol Mencit Putih (Mus musculus)

“…Beberapa penelitian mengenai khasiat bawang putih terhadap kadar kolesterol telah dipublikasikan. Pradana dalam publikasinya yang berjudul Terapi Hiperkolesterol Pada Mencit (Mus musculus) Strain BALB/C Betina Umur 2 Bulan Menggunakan Sari Bawang Putih menyimpulkan bahwa sari bawang putih dapat digunakan untuk terapi penurunan kadar kolesterol dalam darah (Pradana and Suryanto, 2017). Dalam penelitannya Pramitasari menyimpulkan bahwa bawang putih dapat memperbaiki profil lipid dan pada dosis 0,2 g dapat memperbaiki profil lipid paling besar (Pramitasari et al ., 2012).…”

“…Pengaruh ekstrak etanol bawang putih dalam membantu menurunkan kadar kolesterol mencit ini disebabkan karena adanya kandungan senyawa allicin yang dapat digunakan untuk menurunkan kadar kolesterol (Yeh and Liu, 2001). Mekanismenya dengan mengurangi sintesis kolesterol, menghambat sintesis asam lemak dan agregasi trombosit dan mencegah thrombosis (Pradana and Suryanto, 2017).…”