The Anthropological Usefulness of the IgA Allotypic Markers

Schanfield, M. S.; Fudenberg, Η. H.

doi:10.1515/9783110800043.343

Cited by 16 publications

(21 citation statements)

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“…The unusual phenotypes of Gm (f, z, a, x; g, bO, 1, 5, c3)-A2m (11,Gm (z,a,x;g,bO,1,5,Gm (z,a,x;g,bO,1,c3,21,and Gm (f,z,a;bO,1 ,3 ,5 ,c3,5)-A2m (1,2) in French, Iranian, and Iraqi Jews, respectively, are best explained b the exclusively African haplotypes Gmza;L3 (Jenkins and Steinberg, 1966;Jenkins et al, 1970;Steinberg, 197313) and ~~z a ; b c 3 , 5 (Schanfeld and Fudenberg, 1975;Van Loghem and Martensson, 1968). African admixture is not unexpected for Jews living in Africa.…”

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Immunoglobulin allotypes in Jewish populations living in Israel and the United States

Stevenson

Schanfield²,

Sandler

1985

American J Phys Anthropol

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The ongoing interest in the interrelationships of Jewish populations justifies inclusion of the immunoglobulin allotypes in an ethnohistorical analysis. A total of 2,184 serum specimens obtained from unrelated Israeli Jewish and self-identified Milwaukee, WI, Jewish blood donors were classified as Ashkenazi, Sephardi, Asiatic, or North African and tested for G1m (a, x, z, and f), G3m (b0, b1, b3, b5, g), A2m (1 and 2), and Km (1). Selected sera were also tested for G3m (s, t, c3, c5). The estimated maximum likelihood Gm-Am haplotype frequencies were used in a heterogeneity chi-square analysis. The results indicate that there is less heterogeneity within Jewish populations from Europe, Middle East, and North Africa than in corresponding non-Jewish populations representing the same geographical areas. In order to avoid the hazards of a univariate focus, previously published data were incorporated into two additional analyses: 15 populations with information on 16 genetic loci and 24 populations with information on five genetic loci. Both sets of data were analyzed using principal-components and cluster analysis. In both sets of analyses, with the exception of the Yemenite Jews, Jewish populations grouped together. These analyses support the belief that Jewish populations appear to be derived from a common gene pool, and there has been some genetic drift and minimal gene flow with surrounding populations.

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Immunoglobulin allotypes in Jewish populations living in Israel and the United States

Stevenson

Schanfield²,

Sandler

1985

American J Phys Anthropol

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“…Allotyping at the Am locus, which is closely linked to the Gm locus [see Schanfield and Fudenberg, 1975, for review of press], and also that found in a population from southwest Siberia, to the north o f India [Schanfield et al, in press], is usually associated with Am ]. This differentiates it from the Gw117;5 haplo type common in Africa, which is more fre quently associated with Am2 than with ,4m1.…”

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Immunoglobulin (Gm) Allotypes in a Sample of Upper-Caste Hindus from Bengal, India

Ray¹,

Field²

1981

Hum Hered

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A sample of high-caste Hindus from Bengal, India, was found to be polymorphic for five Gm haplotypes, including Gm ^3;5, Gm ^1;21 and Gm ^1,2;21 which are common in Caucasians, and Gm^1,17;5 and Gm^1;13,15,16, both of which may indicate affinities with populations of central and/or southwestern Asia. The frequencies observed in Bengalis are intermediate between those seen in Hindus from northwestern India and from southern India.

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“…The reagents used and specificities tested are presented in table 1. All sera were tested at a dilution of 1/20 on microtiter plates using a stan dard test system with appropriate controls [Schanjiehl, 1971;Schanfield and Fudenberg, 1975]. Any sera with saline-agglutinating activity were heat inactivated at 65 C for 10 min and retyped.…”

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confidence: 99%

Studies on the Immunoglobulin Allotypes of Asiatic Populations

Ms¹,

Te²,

Mh³

1980

Hum Hered

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The results of immunoglobulin typing of 278 Tuvinians for Glm (f, z, a, and x), G3m (b, 0, 1, 3, 5, c3, 5, g, s, t and v), A2m (1 and 2) and Km (1) indicate these southern Siberians to have the Caucasian haplotype Gm^f;b Am¹ (0.100), the Oriental haplotypes Gm^f;a;b Am¹ (0.022), Gm^{f, a;b}Am²(0.040), Gm^{z, a;b, s, t}Am¹ (0.027) and Gm^{z, a;b, s, t}Am² (0.107). The haplotypes distribution for Gm^z;a;gAm¹ (0.279), Gm^{z, a}; sAm²(0.065), Cm^7,^a; ^χ. sAm¹(0.101) and Gm^{z, a,}^x;gAm²(0.030) are similar to those found in oriental populations. The striking feature of this population is the presence of Gm^{z, a;b} Am¹ (0.108) and Gm^{z, a;b} Am² (0.122) previously thought to be characteristic of African or Papuan populations, indicating that a third focus of the Gm^{z, a;b} haplotypes exists in Central Asia. The Km¹frequency observed (0.125) is intermediate between Caucasian and previously studied northern Oriental populations.

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The Anthropological Usefulness of the IgA Allotypic Markers

Cited by 16 publications

References 0 publications

Immunoglobulin allotypes in Jewish populations living in Israel and the United States

Immunoglobulin allotypes in Jewish populations living in Israel and the United States

Immunoglobulin (Gm) Allotypes in a Sample of Upper-Caste Hindus from Bengal, India

Studies on the Immunoglobulin Allotypes of Asiatic Populations

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