The association between anaphylaxis and post-traumatic stress disorder in subjects with Hymenoptera venom allergy

Tal, Yuval; Shany, Golan; Hershko, Alon Y.; Ribak, Yaarit; Mizrahi, Eyal; Shamriz, Oded; Havlin, Ariel; Shalit, Meir; Toker, Ori; Freedman, Sara

doi:10.1016/j.jaip.2019.07.035

Cited by 9 publications

(3 citation statements)

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“…History of FIA was also identified as an independent inducer of maternal anxiety in other studies 12 . Lastly, similar to studies focusing on Hymenoptera‐induced anaphylaxis, 2 FIA can induce symptoms of PTSD. In a pilot study of children aged 7–13 years, Weiss et al.…”

Section: Discussionsupporting

confidence: 54%

“…Accumulating evidence suggests that anaphylaxis may impact patients' mental health and induce different psychological disorders (PDs). 1 Tal et al 2 described increased post-traumatic stress disorder (PTSD) rates in patients who had Hymenoptera-related anaphylaxis, noting a bidirectional relationship between T helper 2 (Th2) immunity and chronic stress as an underlying mechanism. A recently published meta-analysis of 45 studies described impaired health-related quality of life and various PDs in patients with drug-induced anaphylaxis; high rates of depression and anxiety were reported in patients with drug hypersensitivity that resulted in anaphylactic reaction.…”

Section: Introductionmentioning

confidence: 99%

“…Accumulating evidence suggests that anaphylaxis may impact patients' mental health and induce different psychological disorders (PDs) 1 . Tal et al 2 . described increased post‐traumatic stress disorder (PTSD) rates in patients who had Hymenoptera‐related anaphylaxis, noting a bidirectional relationship between T helper 2 (Th2) immunity and chronic stress as an underlying mechanism.…”

Section: Introductionmentioning

confidence: 99%

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Food‐induced anaphylaxis during infancy is associated with later sleeping and eating disorders

Nemet,

Elbirt,

Mahlab‐Guri

et al. 2023

Pediatric Allergy Immunology

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BackgroundAccumulating evidence suggests that food‐induced anaphylaxis (FIA) may induce different psychological disorders (PDs). In this study, we aimed to further evaluate the effect of FIA, specifically when occurring in early life, on subsequent PDs development.MethodsWe conducted a population‐based, retrospective, matched‐cohort study of pediatric patients (age ≤ 18 years) treated at the “Clalit” healthcare organization during the period 2001–2021. Children diagnosed with FIA were propensity score‐matched with patients without any allergies (controls) of similar demographic parameters. Associations between FIA and different PDs were examined by multivariable regression models.ResultsThe cohorts comprised 545 FIA patients and 4514 controls. Most patients were <3 years old [87.6% of controls (N = 3955) and 87.3% of the FIA cohort (N = 476)]. In this age group, the major food allergens were cow's milk (N = 258; 54.2%), eggs (N = 60; 12.6%), and peanuts (N = 20; 4.2%). The multivariable regression model identified an association between FIA and any PDs (p < .001), sleeping disorders (p < .001), and eating disorders (p = .050). Kaplan–Meier curves revealed that patients who experienced FIA before 3 years of age had an increased cumulative risk over the follow‐up time of developing any PDs, sleeping disorders, and eating disorders.ConclusionFIA during the first 3 years of life increases the risk of later developing eating and sleeping disorders, which can last into adulthood. Further attention should be focused on accurately diagnosing these children.

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Section: Discussionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%