The association of serum prolidase activity with the presence and severity of coronary artery disease

Abstract

Findings of this study have shown that serum prolidase activity is significantly associated with the presence and severity of CAD, and elevated serum prolidase activity might be an independent predictor of coronary atherosclerosis.

The Association of Serum Prolidase Activity and Erectile Dysfunction

“…Moreover, the degree of severity of oxidative stress is directly correlated with the inhibition of collagen production, and prolidase is supposed to be the target enzyme of this process (Sienkiewicz et al, 2004). Yildiz et al (2008) showed that serum prolidase activity in an increasing manner was significantly associated with the presence and severity of CAD. In addition, it was suggested that hypertension and its duration are associated with increased serum prolidase activity, and it may be a marker for the follow-up of hypertensive patients (Demirbag et al, 2007).…”

“…Its activity has been documented in plasma, erythrocytes, leukocytes, dermal fibroblasts, and various organs, such as kidney, brain, heart, thymus, uterus, liver, small intestine, stomach, spleen, lung, and pancreas (Zanaboni et al, 1994;Liu et al, 2007). Prolidase activity has been investigated in various disorders, such as chronic liver disease (Myara et al, 1984), osteoporosis (Erbagci et al, 2002), osteoarthritis (Altindag et al, 2007), uremia (Gejyo et al, 1983), and hypertension (Demirbag et al, 2007), and in the presence and severity of coronary artery disease (Yildiz et al, 2008).…”

Serum prolidase activity and oxidative–antioxidative status in patients with developmental dysplasia of the hip and its relationship with radiographic severity

“…15 Briefly, 1 ml of buffer containing 0.1 M Tris; 10 mmol/l EDTA ( pH 8.2); and 50 ml of serum, was added to cuvettes, followed by 50 ml of 10 mmol// 5,5 ′ -dithiobis(2-nitrobenzoic acid) in methanol. Blanks were run for each sample as a test.…”

Dilatation of the Ascending Aorta Is Associated with Low Serum Prolidase Activity

“…Previously it has been shown that prolidase activity in normal fibroblasts is regulated by the interaction of extracellular matrix proteins, mainly type I collagen with b1 integrin receptor (Palka and Phang 1997). Previous clinical studies have shown increased serum prolidase activity, which indicates increased collagen turnover, in chronic liver disease, coronary artery disease (Myara et al 1984;Yildiz et al 2008). Conversely deficient/reduced serum prolidase activity was reported to be associated with lupus-like syndrome characterized by nonhealing skin ulcers owing to defective collagen turnover (Shrinath et al 1997).…”

“…The enzyme plays a key role in the recycling of proline for collagen turnover and cell growth. Prolidase enzyme activity has been investigated in various disorders such as chronic liver disease, coronary artery disease (Myara et al 1984;Yildiz et al 2008).…”