The blood supply of the cat's visual cortex and its postnatal development

Tieman, Suzannah Bliss; Möllers, Sven; Tieman, David G.; White, Jacqueline K.

doi:10.1016/j.brainres.2003.11.023

Cited by 38 publications

(31 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The relatively minimal change in StO 2 , despite the marked increases in HbT, CBV, and CMRO 2 , may indicate that, in healthy infants, oxygen delivery to different brain regions and at different ages closely matches the local consumption. This result agrees with the hypothesis that increases in cerebral blood volume in different cortical regions occur in parallel and are tightly coupled with increases in the metabolic demand of neurons during development (35).…”

Section: Optical Brain Development Studysupporting

confidence: 91%

Assessment of Infant Brain Development With Frequency-Domain Near-Infrared Spectroscopy

et al. 2007

View full text Add to dashboard Cite

This is the first report to demonstrate quantitative monitoring of infant brain development with frequency-domain nearinfrared spectroscopy (FD-NIRS). Regionally specific increases in blood volume and oxygen consumption were measured in healthy infants during their first year. The results agree with prior PET and SPECT reports; but, unlike these methods, FD-NIRS is portable and uses nonionizing radiation. Further, new information includes the relatively constant tissue oxygenation with age and location, suggesting a tight control between local oxygen delivery and consumption in healthy infants during brain development. FD-NIRS could become the preferred clinical tool for quantitatively assessing infant brain development. T he rate of growth and development in the first year of life is unmatched at any other time during postnatal development (1). However, with rapid growth comes increased vulnerability to disorders arising from genetic defects, gene expression, and environmental exposures. Injuries or abnormal gene expressions occurring early in life are expected to have profound effects on neuronal organization and integrated neuronal activity as many axono-dendritic connections are formed and the majority of myelination occurs in the first year (2). Despite the high vulnerability in the first year, there are very few tools available for assessment of brain health and current clinical exams are notoriously insensitive. To better understand normal developmental trajectories and to distinguish abnormal from normal trajectories at an early time point, a safe, inexpensive, portable technique for quantitative, reliable monitoring of regional brain development is needed.Current understandings of regional brain development in infants derive from PET and SPECT studies, with the inherent risk of radiation exposure, and from MRI studies, which, although safe, typically require sedation of infants more than a few weeks old to prevent movements during the scans. Most studies conducted with these techniques are in fact performed for other clinical indications with small populations of unhealthy infants. Using 2-deoxy-2[18 F]-fluoro-D-glucose PET,Chugani and Phelps (3) has demonstrated a correlation between glucose utilization and behavioral and neurophysiological maturation. In newborns, glucose uptake is highest in the sensorimotor cortex, with generally low functional activity over most of the remaining cerebral cortex. During the second and third months, glucose uptake begins to increase in the parietal, temporal and primary visual cortices. This coincides with improvements in motor and visual skills at this age (4,5), as well as with changes in the EEG response to stimuli (6). Glucose uptake has increased in the lateral inferior frontal cortex by 6 -8 mo, and by 12 mo in the dorsal and medial frontal cortex. At the same time, infants show improved cognitive and behavioral performance. By approximately 1 y of age, the pattern of glucose utilization in an infant resembles that of an adult (7). Other investigators...

show abstract

Section: Optical Brain Development Studysupporting

confidence: 91%

Assessment of Infant Brain Development With Frequency-Domain Near-Infrared Spectroscopy

et al. 2007

View full text Add to dashboard Cite

show abstract

“…∆R 2 * value (in gray bar) is linearly related to baseline CBV; CBV is the highest at the surface of the cortex and the lowest in white matter. The middle of the cortex (indicated by green lines) has the highest CBV within the cortex, which is consistent with microvascular histological studies (Tieman et al 2004). Green arrows: penetrating intracortical vessels.…”

Section: Fmri With Contrast Agentsupporting

confidence: 74%

Animal Model Studies

Kim

Jin

Kim

et al. 2015

fMRI: From Nuclear Spins to Brain Functions

View full text Add to dashboard Cite

“…The concept of vascular unit, which limits the PSF and spatial accuracy of various fMRI techniques [131,132 ], has been proposed [31]. To date, apart from a few sporadic illustrations using fixed tissues [31][32][33][34]36,38,100,[133][134][135][136][137][138], a detailed analysis of vascular unit (e.g. the density and spacing of intracortical vessels) on the vast cortical plate is still lacking (but see [37 ]).…”

Section: Resultsmentioning

confidence: 99%

“…Across rodents [32,33], cats [34], monkeys [35,36,37 ] and humans [31,38], the capillary density is highest in layer IV, lower in superficial layers and lowest in deep layers. Although vascular densities across layers do not correlate well with neuronal and synaptic densities [33,36], they are strongly correlated with the steady-state metabolic demand measured by cytochrome oxidase activity [35,36] …”

Section: Resolving Cortical Layers With High-resolution Functional Mrimentioning

confidence: 99%