The clinical application and efficacy of sodium hyaluronate–carboxymethylcellulose during tympanomastoid surgery

Lee

et al. 2018

International Surgery

The aim of the study was to compare the efficacy and safety between an autocrosslinked polysaccharide (ACP) gel (Hyalobarrier) and a poloxamer/sodium alginate (P/SA: Guardix-SG) in preventing adhesions after thyroidectomy and demonstrate the noninferiority of ACP gel to P/SA. To identify differences of antiadhesive efficacy and safety between the ACP gel and P/SA, we investigated various variables such as the proportion of normal esophageal motility as assessed using marshmallow esophagography, swallowing impairment, adhesion severity and so on. This prospective, randomized, double-blinded, multicenter, phase III study investigated the antiadhesive efficacy and safety of ACP gel compared with those of P/SA for 12 weeks. Subjects were randomly assigned to receive either ACP gel (n = 97) or P/SA (n = 96). The primary endpoint was the proportion of normal esophageal motility as assessed using marshmallow esophagography, while the secondary endpoints included swallowing impairment, adhesion severity, laryngoscopic assessment of the vocal cords, and voice range profile. Safety endpoints included adverse events. There was no significant difference between the ACP gel and P/SA groups in the proportion of normal esophageal motility as the primary endpoint ( P = 0.7428). In addition, there were no differences in the secondary or safety endpoints between the 2 groups. It was demonstrated that ACP gel was not inferior to P/SA. ACP gel appears both effective and safe for use in preventing adhesions after thyroidectomy.

Section: Discussionmentioning

confidence: 99%

Prospective, Randomized, Double Blind, Multicenter Study for an Autocrosslinked Polysaccharide Gel to Evaluate Antiadhesive Effect and Safety Compared to Poloxamer/Sodium Alginate After Thyroidectomy

Lee

et al. 2018

International Surgery

“…Subjects were recruited until the necessary number of subjects was reached. Patients were not admitted to the study if any of the following criteria were present: 1) previous tympanomastoid surgery on the same side, 2) a diagnosis of adhesive otitis, 3) absence of malleus or TTM tendon …”

Section: Methodsmentioning

confidence: 99%

“…Patients were not admitted to the study if any of the following criteria were present: 1) previous tympanomastoid surgery on the same side, 2) a diagnosis of adhesive otitis, 3) absence of malleus or TTM tendon. 3 Patients were assigned into two groups alternately. In group 1, the TTM tensor would be removed during the surgery, whereas it would be retained in group 2.…”

Section: Patient Selectionmentioning

confidence: 99%

Is it necessary to retain the tensor tympani tendon in tympanoplasty?

Deng

Tao

et al. 2015

The Laryngoscope

“…However, adverse effects such as fibrosis resulting in suboptimal hearing outcomes, plagues the use of gelatin. To overcome this problem it has been proposed the use of sodium hyaluronate (HA) and CMC [ 135 ]. HA is an inert and safe glycosaminoglycan easy to use and able to remain at the desired biological site for long period.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Potential Applications of Nanocellulose-Containing Materials in the Biomedical Field

et al. 2017

Because of its high biocompatibility, bio-degradability, low-cost and easy availability, cellulose finds application in disparate areas of research. Here we focus our attention on the most recent and attractive potential applications of cellulose in the biomedical field. We first describe the chemical/structural composition of cellulose fibers, the cellulose sources/features and cellulose chemical modifications employed to improve its properties. We then move to the description of cellulose potential applications in biomedicine. In this field, cellulose is most considered in recent research in the form of nano-sized particle, i.e., nanofiber cellulose (NFC) or cellulose nanocrystal (CNC). NFC is obtained from cellulose via chemical and mechanical methods. CNC can be obtained from macroscopic or microscopic forms of cellulose following strong acid hydrolysis. NFC and CNC are used for several reasons including the mechanical properties, the extended surface area and the low toxicity. Here we present some potential applications of nano-sized cellulose in the fields of wound healing, bone-cartilage regeneration, dental application and different human diseases including cancer. To witness the close proximity of nano-sized cellulose to the practical biomedical use, examples of recent clinical trials are also reported. Altogether, the described examples strongly support the enormous application potential of nano-sized cellulose in the biomedical field.