The common genetic variants of toll-like receptor and susceptibilityto adenoid hypertrophy: a hospital-based cohort study

Babademez, Mehmet Alı; Özdaş, Talih; Özdaş, Sibel

doi:10.3906/sag-1511-16

Cited by 9 publications

(8 citation statements)

References 40 publications

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“…However, Bani-Ata et al indicated a low significance of tonsillectomy in parental and sibling histories [ 19 ], but the size of palatine tonsils is not the main indication for tonsillectomy; therefore, it is difficult to compare a family predisposition to adenoidectomy with tonsillectomy. However, recurrent or chronic inflammation susceptibility of the adenoids or palatine tonsil tissue may lead to chronic activation of the cell-mediated and humoral immune response, which may play a role in hypertrophy [ 20 ]. This susceptibility to infection may be caused by genetic dispositions.…”

Section: Discussionmentioning

confidence: 99%

“…This susceptibility to infection may be caused by genetic dispositions. The role of different variations in inflammatory genetic factors, such as polymorphisms of mannose binding lectin (MBL), toll-like receptors (TLRs), secretoglobulins (SCGBs), or IL-10, were analyzed [ 20 , 21 , 22 , 23 ]. Grasso et al found that the MBL2 00 genotype is a prognostic marker of AH in children [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…Grasso et al found that the MBL2 00 genotype is a prognostic marker of AH in children [ 21 ]. Meanwhile, Babademez et al stated that TLR4 polymorphisms were associated with an increased risk of AH, but they did not find the same association when they analyzed TLR2 polymorphisms [ 20 ]. In addition, in the work of Özdaş et al, the presence of single nucleotide polymorphisms (SNPs) of secretoglobulins were associated with an increased risk of AH [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

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Siblings’ Risk of Adenoid Hypertrophy: A Cohort Study in Children

Zwierz

Domagalski

Masna

et al. 2023

IJERPH

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Background: The aim of this study was to compare adenoid size in preschool-age siblings using flexible nasopharyngoscopy examination (FNE) when they reach the same age. The occurrence of adenoid symptoms in these patients was also analyzed. This study was conducted to analyze the adenoid size in siblings when they reach the same age and substantiate a correlation between adenoid hypertrophy (AH) and adenoid symptoms. Methods: We analyzed and reported on the symptoms, ENT examination results, and FNE of 49 pairs of siblings who were examined at the same age. Results: There was a strong association in adenoid size between siblings when they are at a similar age (r = 0.673, p < 0.001). Second-born children whose older sibling had IIIo AH (A/C ratio > 65%) had a risk of IIIo AH 26 times greater than patients whose older sibling did not have IIIo AH (OR = 26.30, 95% CI = 2.82–245.54). Over 90% of snoring children whose siblings had confirmed IIIo AH would develop IIIo AH by the time they reach the same age. Second-born children in whom snoring occurs and whose older siblings have a IIIo AH have about a 46 times higher risk of IIIo AH compared to patients who did not meet these two conditions (p < 0.001, OR = 46.67, 95% CI = 8.37–260.30). Conclusions: A significant familial correlation between adenoid size in siblings when they reach the same age was shown. If the older sibling has a confirmed overgrown adenoid (IIIo AH) and their younger sibling presents adenoid symptoms, particularly snoring, it is highly probable that they will also have an overgrown adenoid.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Siblings’ Risk of Adenoid Hypertrophy: A Cohort Study in Children

Zwierz

Domagalski

Masna

et al. 2023

IJERPH

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“…Интересно, что другие исследования показали, что полиморфизм rs1800896 в гене IL-10 может быть Бронхопульмонология и отоларингология связан с заболеваемостью ВЭБ и вирусом, ассоциированным с гемофагоцитарным лимфогистиоцитозом (ВЭБ-ГЛГ) у детей, а генотип АА и аллель А могут быть чувствительными факторами риска для ВЭБ-ГЛГ [50]. Кроме того, в предыдущих работах было показано, что полиморфизм гена MBL2 (SNP 49 C/T rs5030737) [23], генотипы AG + GG и AG по TLR4-D299G [51], Ugrp2 [52], генотипы 2R, 2R, IL-1Ra и T и T IL-1b [53] были связаны с повышенным риском развития ГГМ. Наши результаты позволяют предположить, что генотип GG по IL-10 rs1800896 играет роль в устойчивости к ГГМ и может предотвращать разрастание ткани глоточной миндалины до максимального размера.…”

Section: Discussionunclassified

<i>G-1082A</i> IL-10 polymorphism as a predictor of adenoid hypertrophy in children with human herpes virus

et al. 2023

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Introduction. Adenoid hypertrophy (pharyngeal tonsil hypertrophy) is considered as one of the most common diseases of the ENT organs.Aim. To study the polymorphism of the IL-10 gene (interleukin 10) and infections caused by human herpesvirus 6 (HHV6), cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in children with AH.Materials and methods. The study included 106 children with adenoid hypertrophy and 38 healthy children aged 2 to 11 years. All children with adenoid hypertrophy were divided into three subgroups depending on the size of the pharyngeal tonsil. Viruses were determined by real-time quantitative polymerase chain reaction (PCR).Results. In patients with AH, HHV6 was detected more often than in CMV and EBV. Among the three subgroups of children with HGM, HHV6 and EBV infections prevailed in children with the maximum degree of pharyngeal tonsil hypertrophy. The frequency of the GG genotype was higher in the control group of children. Significantly higher frequencies of the G allele and GG and GA genotypes for IL-10 rs1800896 were found in the subgroup of children with the smallest size of the pharyngeal tonsil compared to other subgroups.Discussions. The frequencies of HHV-6 and CMV in the control group are significantly different. HHV-6 was the most frequently detected virus in patients with HGM compared with CMV and EBV. The frequency of the GG genotype was in the control group of children. A significantly higher frequency of the G allele and GG genotypes was found in the first subgroup of children compared to the second and exclusive subgroups. We found a lower frequency of the G allele and GG and GA genotypes in a significant subgroup of children compared to the second subgroup. Previous studies show a significant increase in the frequency of the A allele and the AA and IL-10 genotypes (rs1800896-1082G/A) in patients resistant to HHV-6 and CMV infections compared to those infected.Conclusions. The presence of HHV-6 and CMV infections contributes to the development of pharyngeal tonsil hypertrophy, and HHV-6 and EBV may contribute to the size of the pharyngeal tonsil.

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“…In the nasal polyposis and control groups, the genotypes in TLR2 (2258 A>G), TLR4 (896 A>G), and TLR4 (1196 C>T) polymorphisms preserved the H-W equilibrium (All P > .005; Table 3). [14][15][16][17]…”

Section: Hardy-weinberg Equilibriummentioning

confidence: 99%

Association of Toll-Like Receptor Polymorphisms With Nasal Polyposis

Kesici¹,

Kaytez

Özdaş

et al. 2019

Ear Nose Throat J

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Nasal polyposis is a disease characterized with chronic inflammation of the nasal mucosa. Toll-like receptors (TLRs) are defined as essential receptors of the innate immune system and may play in the development of nasal polyposis. A total of 71 patients with nasal polyposis and 74 healthy controls were included in this study. Three single-nucleotide polymorphisms (SNPs); TLR2 (2258 A>G), TLR4 (896 A>G), and TLR4 (1196 C>T) were analyzed in all patients. The degree of pair-wise linkage disequilibrium and the genotype and haplotype analyses were conducted using regression in this logistic model and the Multifactor Dimensionality Reduction (MDR) software package was used to construct all possible interactions among different genotype variants belonging to the TLR gene. There was significant difference in genotype and allele frequencies of the TLR4 (1196 C>T) polymorphism between the nasal polyposis and control groups (0.017). Also, it was observed that the probability of nasal polyposis was 62.7% in the presence of TLR4 (1196 C>T) polymorphism with asthma ( P = .007). As a conclusion, this study showed that TLR4 and TLR2 polymorphisms were predisposing factors for nasal polyposis. Further functional studies investigating the consequences of loss of TLR function are needed.

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The common genetic variants of toll-like receptor and susceptibilityto adenoid hypertrophy: a hospital-based cohort study

Cited by 9 publications

References 40 publications

Siblings’ Risk of Adenoid Hypertrophy: A Cohort Study in Children

Siblings’ Risk of Adenoid Hypertrophy: A Cohort Study in Children

<i>G-1082A</i> IL-10 polymorphism as a predictor of adenoid hypertrophy in children with human herpes virus

Association of Toll-Like Receptor Polymorphisms With Nasal Polyposis

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