The connection of alpha‐1 acid glycoprotein inflammatory marker with anthropometric, hormonal, and metabolic characteristic of women with polycystic ovary syndrome

Abstract

Aim: To investigate the connection of alpha-1 acid glycoprotein inflammatory biomarker with clinical, hormonal, and metabolic characteristics in women with polycystic ovary syndrome (PCOS) and normal cycling controls. Methods: A cross-sectional study was conducted on 235 women with PCOS and 92 normal cycling controls attended between 2008 and 2018. Alpha-1 acid glycoprotein levels were correlated with clinical, anthropometric, anthropometric-metabolic indexes, and hormones of women with PCOS and controls. Simple and multivariate stepwise linear regression, matched for age and body mass index confounding variables, was performed. Results: Alpha-1 acid glycoprotein levels were higher in women with PCOS (p = 0.0016). In controls, it was positively correlated with waist circumference, fat mass, body adiposity index, and lipid accumulation product, and negatively correlated with sex hormone-binding globulin (p < 0.005 for all comparisons). In PCOS, it was positively correlated with testosterone, most biomarkers of central adiposity, homeostatic model assessment of insulin-resistant, erythrocyte sedimentation rate, and negatively correlated with sex hormonebinding globulin, high-density lipoprotein cholesterol, glucose/insulin ratio, and lymphocytes (p < 0.055 for all comparisons). After multivariate regression in women with PCOS, alpha-1 acid glycoprotein retained a significant positive correlation with erythrocyte sedimentation rate and C-reactive protein.Conclusions: In PCOS, alpha-1 acid glycoprotein is correlated with biomarkers of adiposity, carbohydrate metabolism, and total testosterone. This inflammatory marker is also correlated with erythrocyte sedimentation rate, neutrophils, and lymphocytes, frequent markers of an inflammation state.

High-Fiber Diet or Combined With Acarbose Alleviates Heterogeneous Phenotypes of Polycystic Ovary Syndrome by Regulating Gut Microbiota

“…a-AGP may modulate energy homeostasis and food intake by interacting with leptin receptor (43). In PCOS, a-AGP level was higher and correlated with biomarkers of adiposity and total testosterone (44). Adiponectin mediates insulin-sensitizing effect through binding to its receptors AdipoR1 and AdipoR2 (42).…”

Screening and verification of genes related to polycystic ovary syndrome

“…Consistent with the results of this present study, a previous study found that by comparison with controls, women with PCOS had higher serum ORM1 levels, which were positively correlated with testosterone, erythrocyte sedimentation rate, C-reactive protein, and negatively correlated with sex hormone-binding globulin, HDL, and glucose/insulin ratio. 28…”

Translational Bioinformatics for Human Reproductive Biology Research: Examples, Opportunities and Challenges for a Future Reproductive Medicine

“…Zheng et al [121] identified 21 genes that recognize asymptomatic sexually transmitted infection (STI)-induced endometritis and distinguish it from non-STI pelvic pain and other diseases. Inflammatory biomarkers such as serum amyloid A, alpha-1 acid glycoprotein, peroxiredoxin 4 (Prx4), trimethylamine-Noxide (TMAO), interferons (IFN)-γ, C-reactive protein (CRP)/albumin ratio, IFN γ-induced protein 10 kDa (IP10/CXCL10), heme oxygenase-1 and procalcitonin (PCT) [122][123][124][125][126][127][128][129][130] are involved in pathophysiological processes such as sex hormones, insulin, cell proliferation, oxidative stress and lipid metabolism in PCOS, so they can be used as effective biomarkers to predict PCOS and to predict the risk of cardiovascular disease [131,132] and chronic lowgrade inflammation in offspring [133]. A recent study [134] showed that the inflammatory reaction coordinated by nuclear factor (NF)-κB signaling is exacerbated by abnormalities in the estrogen receptor-β and progesterone receptor pathways, and that these pathways are also affected by local inflammation, creating a dysregulated inflammatory-hormonal circuit, providing new insights into the origin and pathogenesis of endometriosis.…”