The correlation between bone mineral density/trabecular bone score and body mass index, height, and weight

Abstract

ObjectivesThis study investigated the correlation between bone mineral density (BMD)/trabecular bone score (TBS) and body mass index (BMI), height and weight in Korean adults.MethodsWe enrolled 2555 female participants in their 20s–80s and 1631 male participants in their 20s–70s. Participants with history of previous vertebral surgeries or current vertebral diseases were excluded. Female and male participants were divided into osteoporosis group (n = 136 and n = 31, respectively), osteopenia group (n = 822 and n = 460, respectively), and normal group (n = 1596 and n = 1140, respectively) based on their BMD T-score. Dual-energy X-ray absorptiometry image analysis and linear regression analysis were conducted on each participant in each group to determine the P-value and the correlation between BMD T-score/TBS T-score and BMI, weight, and height.ResultsWe found a significant correlation between BMI and TBS in both male and female participants. In the male participants, the correlation coefficient increased progressively from the normal group to the osteoporosis group. In the female group, we observed a significant positive correlation between height and TBS, and in the male group a significant negative correlation between weight and TBS was observed.ConclusionsBMI and weight are closely correlated to body fat content. BMD was positively correlated to BMI and weight, while TBS was negatively correlated to BMI and weight. Therefore, although BMI causes an increase in BMD, it appears to be negatively affecting bone quality.

Effect of Weight Change Following Intentional Weight Loss on Bone Health in Older Adults with Obesity

“…For example, increases in bone marrow adipogenesis were associated with osteoporosis and age‐related bone loss, suggesting stromal cell differentiation into adipocytes rather than osteoblasts . Further evidence linked elevated BMI with lower rates of bone formation , and although a negative relationship between TBS and BMI was previously described , to our knowledge, this is the first study to associate change in fat mass with change in TBS. Because meaningful change thresholds for TBS have yet to be defined, clinical interpretability of our findings is challenging; however, lower TBS is associated with increased fracture risk and may imply that fat mass loss versus lean mass loss with weight loss carries a different fracture risk profile.…”

Relationship of Age, Body Mass Index, Bone Density, and Menopause Duration with Alveolar Bone Resorption in Postmenopausal Women

“…Increased bone loss occurred with age, especially in the elderly. This study divides the duration of menopause into 2 groups, i.e., ≤5 years and >5 years [12].…”

“…2019; 19:e4908 formation process at age >40 years; accordingly, bone mass becomes smaller. After peak bone mass between the ages of 25 and 35 years, bones shrink from 0.3% to 0.5% per year [12,13].…”

Trabecular bone score (TBS) as a noninvasive and complementary tool for clinical diagnosis of bone structure in endocrine disorders

“…As it enables the assessment of bone microarchitectural texture, TBS may be useful in evaluating bone quality. Going further, it may be an independent and additional instrument for assessment of bone, as well as other clinical risk factors and FRAX [17,18].…”