The Correlation of<i>Salvia miltiorrhiza</i>Extract–Induced Regulation of Osteoclastogenesis with the Amount of Components Tanshinone I, Tanshinone IIA, Cryptotanshinone, and Dihydrotanshinone

Kim, Hae-Kyung; Woo, Eun‐Rhan; Lee, Hae-Won; Park, Hyung-Rae; hyunnam, kim; Jung, Yeon-Kwan; Choi, Je‐Yong; Chae, Soo‐Wan; Kim, Hyung‐Ryong; Chae, Han‐Jung

doi:10.1080/08923970801949133

Cited by 43 publications

(26 citation statements)

References 17 publications

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“…Our results are not completely in agreement with those reported by Kim et al, 18,19 the only two published studies on effect of SM on RANKL expression so far. Kim et al 18,19 have found that Tanshinone IIA (isolated from SM) in a dose-dependent manner has some inhibitory effect on RANKL expression in osteoblasts as well as RANK-induced pathways that are involved in osteoclastic differentiation, fusion, and actin ring formation, thus leading to decrease in bone resorption. Our results SALVIA MILTIORRHIZA ON OSTEOBLASTIC CELLS revealed initial increase of RANKL expression before it decreased.…”

Section: Discussioncontrasting

confidence: 90%

“…The different results may be explained by the different experimental design such as time points and concentrations. Most importantly, the present study examines the crude extracts of SM but Kim et al 18,19 only examine Tanshinone IIA, one of the effective compounds isolated from the herb. Lee et al 20 investigated five compounds isolated from SM: Tanshinone IIA, Tanshinone I, Crypotanshinone, 15,16-dihydrotanshinone I, and Ferruginol, and found that Tanshinone IIA's anti-osteoclastogenic effect may lie in its ability to interfere with differentiation signaling rather than reduction in osteoclast precursors or deterioration of the differentiation-supporting ability of osteoblasts.…”

Section: Discussionmentioning

confidence: 99%

“…Total RNA (1 mg) was used to generate cDNA in each sample using SuperScript TM reverse transcriptase (Invitrogen) with 1 mg Oligo(dT) [12][13][14][15][16][17][18] (500 mg/ml) primers.…”

Section: Rna Extraction and Cdna Synthesismentioning

confidence: 99%

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Effects of medicinal herb salvia miltiorrhiza on osteoblastic cells in vitro

Chin

Yang

Chai

et al. 2011

Journal Orthopaedic Research

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Sufficient osteoinduction is essential for the success and effectiveness of bone grafting. It was previously found that Salvia Miltiorrhiza (SM), a commonly used Chinese herb increased osteogenesis in vivo. The aim of this study is to investigate the effects of SM on bone cells in vitro, in an attempt to get a better understanding on how SM can promote bone remodeling. MC3T3-E1, an osteoblastic cell line, was cultured with SM for different time intervals (24, 48, and 72 h), whereas the control group consisted of cells cultured without any intervention. The mRNA expression of alkaline phosphatase (ALP), osteocalcin (OCN), osteoprotegerin (OPG), and the receptor activator of nuclear factor kappa B ligand (RANKL) were examined by real-time polymerase chain reaction (qPCR). The expression of ALP showed an early increase at 24 h by 50% (p < 0.001) and at 48 h by 13% (p < 0.001). OCN was decreased by 22% at 24 h (p < 0.001) but increased by 50% and 88% at 48 and 72 h, respectively (p < 0.001). RANKL showed an early increase at the first two time points of 24 and 48 h by 45% (p < 0.001) and 36% (p < 0.01), respectively, while OPG was up-regulated at the latter two time points by 10% at 48 h (p < 0.01) and 68% at 72 h (p < 0.001). Thus, OPG/RANKL was down-regulated first, and then up-regulated. SM enhances bone remodeling by regulating the gene expression of ALP, OCN, OPG, and RANKL. It is a potential medicinal herb to be utilized in the application that requires stimulation in bone cell activities. ß

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Section: Discussioncontrasting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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Effects of medicinal herb salvia miltiorrhiza on osteoblastic cells in vitro

Chin

Yang

Chai

et al. 2011

Journal Orthopaedic Research

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“…Salvia miltiorrhiza increased osteoblast number and inhibited osteoclastogenesis (82). Isolated from Salvia miltiorrhiza Bunge, tanshinone IIA, tanshinone I, cryptotanshinone, 15,16-dihydrotanshinone I, and ferruginol were found to reduce the formation of TRAP positive multinuclear osteoclasts (83).…”

Section: In Vitro Findingsmentioning

confidence: 99%

Chinese single herbs and active ingredients for postmenopausal osteoporosis: From preclinical evidence to action mechanism

Lin

Wang

Zhang

et al. 2017

BST

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“…It has been reported that compounds isolated from soft corals possess potent anticancer as well as chemopreventive activity (Hegazy et al, 2012;SuarezJimenez et al, 2012). Diterpenoids are a group of biologically active compounds derived from marine soft corals that have shown an anti-inflammatory, antioxidant antiosteoporotic activity (Takaki et al, 2003;Kim et al, 2008;Wanzola et al, 2010). Recently, Nguyen Phuong Thao et al reported that diterpenoids (Figures 3A-D) derived from Vietnamese soft corals Sinularia maxima and Lobophytum crassum exhibited anti-osteoclastogenic, radical scavenging and reducing capacity.…”

Section: Marine Soft Coralsmentioning

confidence: 99%

Marine Natural Products: New Avenue in Treatment of Osteoporosis

Chaugule¹,

Indap²,

Chiplunkar

2017

Front. Mar. Sci.

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Bone metabolism is a physiological process that maintains the skeletal integrity and bone functions. Skeletal integrity is always balanced by two key cell types-bone resorbing osteoclasts and bone-forming osteoblasts. Imbalance between generation and function of osteoclasts and osteoblasts often leads to pathological conditions such as osteoporosis, osteopetrosis, Paget's disease. Osteoporosis is one of the most common age-related diseases characterized by decreased bone mineral density and microarchitectural deterioration. Current therapies are indeed effective in preventing bone loss but are also followed by side effects. Since many years, marine organisms have been considered as a good source of bioactive molecules or compounds with potential pharmaceutical properties. Marine Natural Products (MNPs) derived from various marine resources such as marine cyanobacteria, dinoflagellates, algae, sponges, soft corals, molluscs, fishes, and mangroves had shown profound effect on bone metabolism through inhibiting osteoclastogenesis and up-regulating osteoblastogenesis via modulating RANK/RANKL/OPG pathway. Amongst the pre-clinically investigated MNPs for management of osteoporosis, very few are under phase I clinical trials. This review discusses the currently available pharmacological drugs and there major health concern in osteoporosis treatment. It further gives an insight into various marine resources and marine-derived bioactive products, depicting their mechanism of action, functional role, and how these can be exploited for the treatment of osteoporosis.

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The Correlation ofSalvia miltiorrhizaExtract–Induced Regulation of Osteoclastogenesis with the Amount of Components Tanshinone I, Tanshinone IIA, Cryptotanshinone, and Dihydrotanshinone

Cited by 43 publications

References 17 publications

Effects of medicinal herb salvia miltiorrhiza on osteoblastic cells in vitro

Effects of medicinal herb salvia miltiorrhiza on osteoblastic cells in vitro

Chinese single herbs and active ingredients for postmenopausal osteoporosis: From preclinical evidence to action mechanism

Marine Natural Products: New Avenue in Treatment of Osteoporosis

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