The effect of body condition on propofol requirement in dogs

Boveri, Sarah; Brearley, J.C.; Dugdale, Alex

doi:10.1111/vaa.12034

Cited by 17 publications

(18 citation statements)

References 20 publications

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“…Signalment plays a role in the induction dose requirements in dogs. A study performed by Boveri, Brearley and Dugdale ( 2013 ) highlighted the importance of calculating propofol dose requirements based on lean body mass. Body condition score was not assessed during the pre-anaesthetic clinical examination, which is a limitation in the present study as it may have provided a more accurate dose requirement for the dogs induced with propofol.…”

Section: Discussionmentioning

confidence: 99%

Anaesthetic induction and recovery characteristics of a diazepam-ketamine combination compared with propofol in dogs

Ferreira

Dzikit

Zeiler

et al. 2015

J. S. Afr. Vet. Assoc.

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Induction of anaesthesia occasionally has been associated with undesirable behaviour in dogs. High quality of induction of anaesthesia with propofol has been well described while in contrast variable induction and recovery quality has been associated with diazepam-ketamine. In this study, anaesthetic induction and recovery characteristics of diazepam-ketamine combination with propofol alone were compared in dogs undergoing elective orchidectomy. Thirty-six healthy adult male dogs were used. After habitus scoring (simple descriptive scale [SDS]), the dogs were sedated with morphine and acepromazine. Forty minutes later a premedication score (SDS) was allocated and general anaesthesia was induced using a combination of diazepam-ketamine (Group D/K) or propofol (Group P) and maintained with isoflurane. Scores for the quality of induction, intubation and degree of myoclonus were allocated (SDS). Orchidectomy was performed after which recovery from anaesthesia was scored (SDS) and times to extubation and standing were recorded. Data were analysed using descriptive statistics and Kappa Reliability and Kendall Tau B tests. Both groups were associated with acceptable quality of induction and recovery from anaesthesia. Group P, however, was associated with a poorer quality of induction (p = 0.014), prolonged induction period (p = 0.0018) and more pronounced myoclonus (p = 0.003), but had better quality of recovery (p = 0.000002) and shorter recovery times (p = 0.035) compared with Group D/K. Diazepam-ketamine and propofol are associated with acceptable induction and recovery from anaesthesia. Propofol had inferior anaesthetic induction characteristics, but superior and quicker recovery from anaesthesia compared with diazepam-ketamine.

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Section: Discussionmentioning

confidence: 99%

Anaesthetic induction and recovery characteristics of a diazepam-ketamine combination compared with propofol in dogs

Ferreira

Dzikit

Zeiler

et al. 2015

J. S. Afr. Vet. Assoc.

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“…A recent study by Boveri et al. () found that dogs with higher body condition scores required lower doses of propofol for induction. A relationship between weight and propofol dose has also been demonstrated in dogs from various sized breeds, where each 10 kg increase in body weight was associated with a 0.3 mg kg −1 reduction in the induction dose of propofol (Griffenhagen et al.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics and pharmacodynamics of propofol with or without 2% benzyl alcohol following a single induction dose administered intravenously in cats

Griffenhagen

Rezende

Gustafson

et al. 2015

Veterinary Anaesthesia and Analgesia

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“…It is important to note that all the animals that participated in this study were of a similar body condition score (Boveri, Brearley & Dugdale 2013), thus obviating the effect of body condition on the pharmacodynamics of each induction agent.…”

Section: Discussionmentioning

confidence: 99%

Effects of thiopentone, propofol and alfaxalone on laryngeal motion during oral laryngoscopy in healthy dogs

Smalle

Hartman

Bester

et al. 2017

Veterinary Anaesthesia and Analgesia

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OTAU staff members for undertaking the feeding, management and housing of the experimental animals.OTAU advisory committee for allowing the participation of the OTAU Beagles in our research project.Final year veterinary students for their assistance in collecting the experimental animals for each data collection and managing the animals on the day of data collection. Special thanks goes out to:Sr Tamarin Fischer for her assistance in housing the animals in the SAS wards.Sr Jana Stander for her assistance in the theatre complex and making instrumentation available to enable data collection.The Faculty of Veterinary Science, Department of Companion Animal Clinical Studies for their financial contributions to make the study a reality.

show abstract

The effect of body condition on propofol requirement in dogs

Cited by 17 publications

References 20 publications

Anaesthetic induction and recovery characteristics of a diazepam-ketamine combination compared with propofol in dogs

Anaesthetic induction and recovery characteristics of a diazepam-ketamine combination compared with propofol in dogs

Pharmacokinetics and pharmacodynamics of propofol with or without 2% benzyl alcohol following a single induction dose administered intravenously in cats

Effects of thiopentone, propofol and alfaxalone on laryngeal motion during oral laryngoscopy in healthy dogs

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