The effect of chronic alcohol intoxication and smoking on the output of salivary immunoglobulin A

Abstract

Abstract:The effect of chronic alcohol intoxication and smoking on the output of salivary immunoglobulin A (IgA) was studied in 37 volunteers: 17 male smoking patients after chronic alcohol intoxication (AS) and 20 control non-smoking male social drinkers (CNS). The DMFT index (decayed, missing, or filled teeth), gingival index and papilla bleeding index (PBI) were assessed. Concentration of IgA in saliva was determined by ELISA. Salivary flow (SF) and IgA output were significantly decreased in AS compared to CNS. There were no significant correlations between the amount of alcohol/cigarettes as well as the duration of alcohol intoxication/smoking, and SF or IgA output, nor between IgA level and SF. Gingival index was significantly higher in AS than in CNS, and was inversely correlated with IgA salivary level. The worsened periodontal state in smoking alcoholdependent persons may result from diminished IgA protection of the oral tissues due to its decreased output.

The Relationship Between Maternal Postpartum Psychological State and Breast Milk Secretory Immunoglobulin A Level

“…However, aside from psychological stress, other factors can also affect the immune system. These factors include age and body mass index (Bachour et al, 2012), smoking (Doni et al, 2013;Waszkiewicz et al, 2012), exercise (Groer & Shelton, 2009;Walsh et al, 2011), chronic diseases (e.g., gestational diabetes; Smilowitz et al, 2013), and infectious diseases (Fetherston, Lai, & Hartmann, 2006). Therefore, these factors must be duly considered if SIgA level is used to evaluate stress, and further studies are needed in this area.…”