The effect of green tea extract supplementation on liver enzymes in patients with nonalcoholic fatty liver disease

Abstract

Background:Green tea is one of the most popular beverages in the world. It is believed to have beneficial effects in the prevention and treatment of many diseases, one of which is nonalcoholic fatty liver disease (NAFLD). The present study investigated the effects of consumption of green tea in NAFLD patients.Methods:This study was a double-blind, placebo-controlled, randomized clinical trial. Ultrasonography was used to diagnose fatty liver in patients with alanine aminotransferase (ALT) >31 mg/dl and 41 mg/dl and aspartate aminotransferase (AST) >31 mg/dl and 47 g/dl in women and men, respectively and without other hepatic diseases. A total of 80 participants (20–50 years) with NAFLD were randomly allocated into two groups to receive either green tea extract (GTE) supplement (500 mg GTE tablet per day) or placebo for 90 days. At baseline and at the end of the intervention weight, serum ALT, AST, and alkaline phosphatase (ALP) were measured in fasting state, and dietary data were collected at baseline and end of the study.Results:Green tea group showed significant reductions in ALT and AST levels after 12 weeks period (P < 0.001). The placebo group showed a reduction in ALT and AST levels at the end of the study, but it was no significant. ALP levels showed significant reductions in both groups after 12 weeks period (P < 0.001).Conclusions:According to the findings of this study, GTE supplementation decrease liver enzymes in patients with NAFLD. It can be claimed that GTE prescribed can be considered as a treatment to improve serum levels of liver enzymes in NAFLD patients.

Green Tea in Non-Alcoholic Fatty Liver Disease: A Double Blind Randomized Clinical Trial

“…The change in ALT was similar in direction, yet not statistically significant. In a similar study on a group of Iranian patients, significant changes were observed in ALT and AST (13). The study of Sakato et al also showed significant changes in ALT but not AST (14).…”

Review of polyphenol‐rich products as potential protective and therapeutic factors against cadmium hepatotoxicity

“…Moreover, in reference to representatives of particular groups of polyphenols there is evidence of their hepatoprotective abilities (Casalino et al, 2002;Eybl et al, 2006;Kowalczyk et al, 2003;Pang et al, 2016;Pari & Shagirtha, 2012). various liver conditions in humans (Boncheva et al, 2013;Chang et al, 2014;Ni et al, 2017;Pezeshki et al, 2016;Soleimani et al, 2016). It is very important that polyphenol-rich food products may be also effective in this organ protection under the conditions of co-exposure to Cd and various noxious substances, including other heavy metals such as lead (Pb) and arsenic (As), occurring in the natural environment, as well as in many occupational settings (Choudhury et al, 2016;Kopeć et al, 2016;Winiarska-Mieczan, 2015).…”

“…It should be underlined that the beneficial properties of these compounds are widely used in the prevention and therapy of numerous diseases in humans, such as obesity, diabetes, cardiovascular diseases and cancer (Bozzetto et al, 2015;Henning et al, 2015;Hokayem et al, 2013;Rasines-Perea & Teissedre, 2017;Tresserra-Rimbau et al, 2014;Venancio et al, 2017). Epidemiological investigations confirm the favorable impact of polyphenols on the liver in people with various diseases of this organ, as well as in healthy individuals (Boncheva et al, 2013;Chang et al, 2014;Ni et al, 2017;Pezeshki et al, 2016;Soleimani et al, 2016). Nevertheless, further studies in this subject are needed to elucidate fully and confirm the potential prophylactic and therapeutic influence of the consumption of products rich in polyphenolic compounds on the liver of humans environmentally and occupationally exposed to Cd.…”

“…sources notably emphasize the possibility of using substances that may increase the antioxidative potential of hepatocytes and combat the adverse effects of Cd-induced oxidative stress at the cellular level such as polyphenolic compounds, vitamins C and E, carotenoids, minerals, tannins, pectin and coenzyme Q10 (Figure 4)(Brzóska, Borowska, & Tomczyk, 2016;Brzóska, Rogalska, et al, 2015;El-Sayed et al, 2016;Gong et al, 2014;Koriem, Fathi, Salem, Akram, & Gamil, 2013;Mężyńska et al, 2016;Ognjanović et al, 2006;Winiarska-Mieczan, 2013).So far, data on the beneficial effect of compounds of plant origin regarding the effect of Cd on the liver have derived mainly from animal models and in vitro studies. However, the well-established effectiveness of these products in the prevention and therapy of various diseases in humans(Boncheva, Georgiev, & Shishov, 2013;Bozzetto et al, 2015;Chang, Peng, Yeh, Kao, & Wang, 2014;Henning et al, 2015;Hokayem et al, 2013;Ni et al, 2017;Pezeshki, Safi, Feizi, Askari, & Karami, 2016;Rasines-Perea & Teissedre, 2017;Soleimani, Paknahad, Askari, Iraj, & Feizi, 2016;Tresserra-Rimbau et al, 2014;Venancio et al, 2017) allows to suppose that these plant ingredients may also be effective in the prevention and treatment of liver injury caused by this toxic metal. Owing to the multidirectional beneficial properties of polyphenols, these compounds seem to be the most promising substances when considering the possible effective agents to counteract and treat Cd hepatotoxicity.…”

Protective Effects of Green Tea and Moringa Leave Extracts and Their Bio-Yoghurts against Oxidative Effects of Lead Acetate in Albino Rats

“…Recently, the effect of GTE supplementation on liver enzymes in patients with nonalcoholic fatty has studied in double-blind, placebo-controlled, randomized clinical trial [52]. Green tea treated group showed significant reductions in ALT and AST levels after 12 weeks of administration (P < 0.001).…”