The Effect of Haramounting Leaf Ethanol Extract (Rhodomyrtus tomentosa (Aiton) Hassk.) on the Number of Leukocyte Type and Histology of Mice Pulmo (Mus Musculus L.) Exposed to Electronic Cigarette

Abstract

BACKGROUND: Haramonting leaves have a large antioxidant activity as inhibitors oxidation and form non-free radical compounds that are not reactive and relatively stable. Electronic smoking is a choice who slowly want to quit conventional smoking.AIM: This research aimed to determine the effect of ethanol extract on hard mounting leaves on leukocyte counts and histology Pulmo on male mice exposed to an electronic cigarette.METHODS: The samples used in this study were healthy male mice aged 8-11 weeks and weight of 25-30 g as many as 25 individuals and ethanol extracts of hard mounting leaves with a dose of 100 mg/kgBW, 200 mg/kgBW and 300 mg/kgBW. Blood tests were carried out at the Health Laboratory of North Sumatra Office, and the preparation of Pulmo histology was carried out at the Pathology and Anatomy Laboratory of Adam Malik General Hospital MedanRESULT: There were significant differences between the control group and all of the treatment groups in the number of lymphocytes, neutrophils, basophils and eosinophils. There was a tendency that electronic cigarette smoke could cause damage to pulmo tissue.CONCLUSION: The results of this study indicate that the ethanol extract of hard mounting leaves could help the immune system in mice exposed to an electronic cigarette.

Effect of Rhodomyrtus tomentosa Hassk. on HIF1α and VEGF expressions on hypertension placental

“…R. tomentosa can also reduce HIF1α better in trophoblast cells aged 8 weeks compared to Zanthoxylum acanthopodium (Situmorang et al, 2022). These plants can decrease lipid peroxidation, enhance the expression of HSP-70, boost the capacity to scavenge free radicals, and improve the histology of the placenta, testis, and lungs (Ilyas and Situmorang, 2021;Ilyas et al, 2019;Irianti et al, 2020;Situmorang and Ilyas, 2018;Situmorang et al, 2020) Due to the high amount of phenolic. It has a strong antioxidant capacity and the potential to be a source of substances that improve health (Vo and Ngo, 2019).…”

Suppression of Fas expression in the hypertensive placental histology of rast given Nano herbal of Rhodomyrtus tomentosa leaves

“…Acclimatisation: The rats were acclimatized for 2 months before being treated in the laboratory in an air-conditioned room with a 12-hour light/dark cycle. Male rats are separated from female rats (Ilyas et al, 2019) 2. Diet for the animals: Rats were fed conventional laboratory diets in the form of pellets and corn and given free access to water.…”

“…Diet for the animals: Rats were fed conventional laboratory diets in the form of pellets and corn and given free access to water. Food was provided ad libitum (Ilyas et al, 2019). 3.…”

“…The leaves are green and have a simple-leaf structure. This plant is often used in traditional Indonesian medicine to treat colic diarrhoea, dysentery, abscesses, bleeding, and high blood pressure and to improve smokers' lungs (Ilyas et al, 2019). Extracts from haramonting contain acylphloroglucinol, flavonoids, tannins, and triterpenes, and the plant exhibits high phenolic and antioxidant activity (Vo & Ngo, 2019).…”

PDGF-β and IL-18 Expressions on Carcinoma Cervical by Rhodomyrtus tomentosa

“…An examination of the pharmacological activity of Rhodomyrtus tomentosa revealed that this edible medicinal herb has antibacterial, antitumor, anti-inflammatory and antioxidant properties both in vivo and in vitro 3 . This herb can reduce lipid peroxidation, increase HSP-70 expression, improve free radical scavenging capacity and improve the histology of placenta and diabetic wounds [4][5][6][7][8] . It has a high antioxidant capacity and is a potential source of health-promoting substances due to its high phenolic content 9 .…”