The effect of hydrofluoric acid treatment of titanium surface on nanostructural and chemical changes and the growth of MC3T3-E1 cells

Lamolle, Sébastien F.; Monjo, Marta; Rubert, Marina; Haugen, Håvard Jostein; Lyngstadaas, Ståle Petter; Ellingsen, Jan Eirik

doi:10.1016/j.biomaterials.2008.10.052

Cited by 201 publications

(158 citation statements)

References 33 publications

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“…Several studies have also shown that hydrophilic surfaces are necessary for biomaterial tissue integration. 15 Other recent studies have shown that the size and characteristics of the features may be more important than the effects of chemical composition alone. 17 Therefore, nanoscale features play an important role in osteogenic differentiation.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6] Many studies have focused on the osseointegration process, and it is now described at both the histological and cellular levels. Previous work has shown that surface characteristics such as roughness, [7][8][9] wettability, [10][11][12][13][14] and surface structures [15][16][17] significantly influence cell differentiation and, as a consequence, osseointegration. 16,18 Bone marrow mesenchymal stem cells (BMMSCs) are multipotent stem cells and represent a particularly attractive source for tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

“…19,20 There are numerous ways that the implant surface can be modified to have nanoscale features added to these surfaces in combination. The most common are chemical processes such as alkaline hydrothermal 20,24,25 or acid 6,15,17,22 oxidation on titanium surfaces to create different nanoscale topographies. Among the common surface nanotopographies, the titania nanotube has drawn much attention.…”

Section: Introductionmentioning

confidence: 99%

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Osteogenic activity of titanium surfaces with nanonetwork structures

Huan¹,

Komasa²,

Taguchi³

et al. 2014

IJN

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Background Titanium surfaces play an important role in affecting osseointegration of dental implants. Previous studies have shown that the titania nanotube promotes osseointegration by enhancing osteogenic differentiation. Only relatively recently have the effects of titanium surfaces with other nanostructures on osteogenic differentiation been investigated. Methods In this study, we used NaOH solutions with concentrations of 2.5, 5.0, 7.5, 10.0, and 12.5 M to develop a simple and useful titanium surface modification that introduces the nanonetwork structures with titania nanosheet (TNS) nanofeatures to the surface of titanium disks. The effects of such a modified nanonetwork structure, with different alkaline concentrations on the osteogenic differentiation of rat bone marrow mesenchymal stem cells (BMMSCs), were evaluated. Results The nanonetwork structures with TNS nanofeatures induced by alkali etching markedly enhanced BMMSC functions of cell adhesion and osteogenesis-related gene expression, and other cell behaviors such as proliferation, alkaline phosphatase activity, extracellular matrix deposition, and mineralization were also significantly increased. These effects were most pronounced when the concentration of NaOH was 10.0 M. Conclusion The results suggest that nanonetwork structures with TNS nanofeatures improved BMMSC proliferation and induced BMMSC osteogenic differentiation. In addition, the surfaces formed with 10.0 M NaOH suggest the potential to improve the clinical performance of dental implants.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Osteogenic activity of titanium surfaces with nanonetwork structures

Huan¹,

Komasa²,

Taguchi³

et al. 2014

IJN

View full text Add to dashboard Cite

show abstract

“…One of the most widely used processes is introducing different chemical and/or biochemical substances on the surface. Such modifications of the atomic composition of the surface have led to significant improvements in the cell response on the surface material both in vitro and in vivo [10][11][12][13] . Impregnation or coating with hydroxyapatite 14,15) or calcium phosphate 16,17) have been proposed as biomimetic approaches.…”

Section: Introductionmentioning

confidence: 99%

In vitro osteoinduction of human mesenchymal stem cells in biomimetic surface modified titanium alloy implants

Santander¹,

Alcaine²,

Lyahyai³

et al. 2012

Dent. Mater. J.

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“…Titanium surfaces with nanostructures show better cell migration and differentiation in vitro 5,6) and improved osteointegration in vivo compared with the traditional titanium surface without nanostructures 7) . Several methods can be utilized to modify titanium surfaces and produce nanostructures, such as alkaline hydrothermal 8,9) or acid oxidation 10,11) . Our previous studies have demonstrated that treatment with high concentrations of alkali can produce a basic, hydrophilic sodium titanate layer with nanonetwork structures on the titanium surface, termed titanium with nanonetwork structures (TNS) 12) .…”

Section: Introductionmentioning

confidence: 99%