The effect of<i>Houttuynia cordata</i>injection on pseudorabies herpesvirus (PrV) infection<i>in vitro</i>

Ren, Xiaofeng; Sui, Xiuwen; Yin, Jun

doi:10.3109/13880209.2010.505242

Cited by 25 publications

(16 citation statements)

References 19 publications

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“…[1] As a result, many TCM injections have become the preferred drug for treating certain diseases, such as cardiovascular diseases,[23] immuno-deficiency,[4] and virus infection. [5] Many modern analytical methods and technologies have been applied to evaluate their quality, including high-performance liquid chromatography (HPLC),[6] HPLC-mass spectrometry (MS),[78] and fingerprinting. [9] However, due to their complicated constituents, how to monitor and control the quality of TCM injections still remains a great challenge.…”

Section: Introductionmentioning

confidence: 99%

The stability investigation of compound Danshen injection (a traditional medicine) with a new high-performance liquid chromatography method

et al. 2013

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Background:Compound Danshen injection (CDSI, a traditional medicine) is an effective drug for the treatment of cardiovascular and cerebrovascular diseases. However, the research about its stability is absent.Objective:A new high-performance liquid chromatography method was developed to assay its main effective constituents, i.e., propanoid acid (PA), protocatechuic aldehyde (PHA), salvianolic acid B (SAB), salvianolic acid A (SAA), and rosmarinic acid (RA). Through the newly found method, the stability of CDSI was to be investigated.Materials and Methods:The analysis was performed by a reverse-phase gradient elution using an aqueous mobile phase (containing 0.1% acetic acid) modified by acetonitrile, and detection was made simultaneously at 280 nm and 325 nm. The method was validated for accuracy, precision and limits of detection. The effects of some environmental storage conditions (light and temperature) on the stability of CDSI were investigated.Results:This method is precise, simple, and convenient. The result showed that illumination and temperature had an obvious effect on CDSI's stability. SAA is the most unstable one among the five components. In the condition of common light, it decomposed rapidly to almost 50% after only 4 h, and 100% after 8 h. PA, RA, and PHA might come from Danshen, was also the transformed products from other components in store process.Conclusion:The result indicated that the main active constituents in CDSI suffered from the illumination and temperature greatly. CDSI should be stored at low temperature and kept away from light.

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Section: Introductionmentioning

confidence: 99%

The stability investigation of compound Danshen injection (a traditional medicine) with a new high-performance liquid chromatography method

et al. 2013

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“…As a medicinal plant, it has been reported to possess important biological properties such as anticancer [2][3][4][5][6][7] , antiviral 8,9 , antioxidant 10,11 , and antiinflammatory activities 12,13 . In Thailand, many of H. cordata fermentation products are commercially available, however, the anticancer activity of these commercialized products remains to be investigated.…”

Section: Introductionmentioning

confidence: 99%

Phenolic acid composition and anticancer activity against human cancer cell lines of the commercially available fermentation products of Houttuynia cordata

Senawong¹,

Khaopha²,

Misuna³

et al. 2014

ScienceAsia

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A number of Houttuynia cordata fermentation products are commercially available in Thailand. However, their anticancer activity remains to be investigated. In this study, the phenolic acid composition and anticancer activity of two commercialized H. cordata fermentation products were investigated. Reversed phase HPLC was used to identify and quantify phenolic acids. MTT and Annexin V staining assays were used to investigate antiproliferative and apoptosis induction activities, respectively. Seven phenolic acids including protocatechuic, p-hydroxybenzoic, vanillic, syringic, p-coumaric, ferulic, and sinapinic acids were detected in the water-soluble constituents of both fermentation products 1 and 2. Water-soluble constituents of fermentation product 2 containing a greater phenolic acid content were more effective than product 1 in inhibiting the growth of HeLa, HCT116, and HT29 cells in a dose-and time-dependent manner. The non-cancer cell line Vero cells appeared to be resistant to both fermentation products. The growth inhibitory effects of both fermentation products in HeLa, HCT116, and HT29 cells included induction of apoptosis. These results suggest that commercially available fermentation products of H. cordata contain several anticancer phenolic acids that may be beneficial in the treatment of human cancer.

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“…Quercetin 3-O-methyl ether and ophioglonin obtained from plants belonging to Ophioglossaceae genus have shown slight activity against HBV [50]. Since 1995 when antiviral activities against enveloped viruses were discovered in extracts of Houttuynia cordata [51], such as influenza, HIV, herpes, SARS and also in enteroviruses [51][52][53][54], 40 compounds have been isolated from the whole plant [55].…”

Section: Resultsmentioning

confidence: 99%

Diversity of Pharmacological Properties in Chinese and European Medicinal Plants: Cytotoxicity, Antiviral and Antitrypanosomal Screening of 82 Herbal Drugs

et al. 2011

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Abstract:In an extensive screening, the antiviral, antitrypanosomal and anticancer properties of extracts from 82 plants used in traditional Chinese medicine and European phytomedicine were determined. Several promising plants that were highly effective against hepatitis B virus (HBV), bovine viral diarrhoea virus (BVDV)-a flavivirus used here as a surrogate in vitro model of hepatitis C virus, trypanosomes (Trypanosoma brucei brucei) and several cancer cell lines were identified. Six aqueous extracts from Celosia cristata, Ophioglossum vulgatum, Houttuynia cordata, Selaginella tamariscina, Alpinia galanga and Alpinia oxyphylla showed significant antiviral effects against BVDV without toxic effects on host embryonic bovine trachea (EBTr) cells, while Evodia lepta, Hedyotis Moreover, among fifteen water extracts that combined high antiproliferative activity (IC 50 0.5-20 µg/mL) and low acute in vitro toxicity (0-10% reduction in cell viability at IC 50 ), Coptis chinensis presented the best beneficial characteristics. In conclusion, traditional herbal medicine from Europe and China still has a potential for new therapeutic targets and therapeutic applications.

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The effect ofHouttuynia cordatainjection on pseudorabies herpesvirus (PrV) infectionin vitro

Cited by 25 publications

References 19 publications

The stability investigation of compound Danshen injection (a traditional medicine) with a new high-performance liquid chromatography method

The stability investigation of compound Danshen injection (a traditional medicine) with a new high-performance liquid chromatography method

Phenolic acid composition and anticancer activity against human cancer cell lines of the commercially available fermentation products of Houttuynia cordata

Diversity of Pharmacological Properties in Chinese and European Medicinal Plants: Cytotoxicity, Antiviral and Antitrypanosomal Screening of 82 Herbal Drugs

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