The Effect of Low-Dose Atropine on Alpha Ganglion Cell Signaling in the Mouse Retina

Wang, Qin; Banerjee, Seema; So, Chung Him; Qiu, Chun Ting; Sze, Ying Hon; Lam, Thomas Chuen; To, Chi‐Ho; Pan, Feng

doi:10.3389/fncel.2021.664491

Cited by 6 publications

(2 citation statements)

References 68 publications

(92 reference statements)

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“…The mechanism of atropine protect myopia might involve the GABAergic signaling by down-regulating GABA transporter 1 (GAT-1) [ 42 ], because GABAergic neurons have atropine-targeting muscarinic acetylcholine receptors (mAChRs). Atropine can also influence RGC possibly via the GABAergic pathway [ 43 ]. However, the GABA synthesis and release will be attenuated by TLR4 activation [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Functions of retinal astrocytes and Müller cells in mammalian myopia

Zhang

Wen

et al. 2022

BMC Ophthalmol

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Background Changes in the retina and choroid blood vessels are regularly observed in myopia. However, if the retinal glial cells, which directly contact blood vessels, play a role in mammalian myopia is unknown. We aimed to explore the potential role and mechanism of retinal glial cells in form deprived myopia. Methods We adapted the mice form-deprivation myopia model by covering the right eye and left the left eye open for control, measured the ocular structure with anterior segment optical coherence tomography, evaluated changes in the morphology and distribution of retinal glial cells by fluorescence staining and western blotting; we also searched the online GEO databases to obtain relative gene lists and confirmed them in the form-deprivation myopia mouse retina at mRNA and protein level. Results Compared with the open eye, the ocular axial length (3.54 ± 0.006 mm v.s. 3.48 ± 0.004 mm, p = 0.027) and vitreous chamber depth (3.07 ± 0.005 mm v.s. 2.98 ± 0.006 mm, p = 0.007) in the covered eye became longer. Both glial fibrillary acidic protein and excitatory amino acid transporters 4 elevated. There were 12 common pathways in human myopia and anoxic astrocytes. The key proteins were also highly relevant to atropine target proteins. In mice, two common pathways were found in myopia and anoxic Müller cells. Seven main genes and four key proteins were significantly changed in the mice form-deprivation myopia retinas. Conclusion Retinal astrocytes and Müller cells were activated in myopia. They may response to stimuli and secretory acting factors, and might be a valid target for atropine.

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Section: Discussionmentioning

confidence: 99%

Functions of retinal astrocytes and Müller cells in mammalian myopia

Zhang

Wen

et al. 2022

BMC Ophthalmol

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“…The prevalence of myopia in boys and girls aged 3 to 19 was estimated to reach about 84% by 2050 [6]. High levels of myopia can lead to cataracts, glaucoma, retinal detachment, and pathological myopia also increase the risk of blindness [7,8]. Myopia has a significantly negative impact on the mood states of boys and girls [9].…”

Section: Introductionmentioning

confidence: 99%

Association of Physical Activity and Sedentary Behaviors with the Risk of Refractive Error in Chinese Urban/Rural Boys and Girls

Zhu

Zhang

et al. 2022

Sustainability

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Background: Research shows physical activity (PA) is negatively associated with refractive error, especially outdoor activity. Our study aimed to examine the association of PA levels and sedentary time (SED) with refractive error in boys and girls living in urban and rural areas. Methods: A total of 8506 urban/rural boys and girls (13.5 ± 2.8 years old) in Shaanxi Province, China participated in this study. Questions about PA, SED, outdoor exercises, and digital screen time were asked in the study survey. Non-cycloplegic refractive error was measured by an autorefractor. The differences between sex/area groups have been analyzed by one-way ANOVA. The association of PA/SED with spherical equivalent (SE) and cylinder power was analyzed by general linear regression. The association between PA/SED and the risk of refractive error was determined using the binary logistic regression model. Results: Of the 8506 participants, the prevalence of refractive error was significantly higher in girls and urban students (p < 0.05). Less SED and digital screen time, and more outdoor activity were significantly associated with SE (p < 0.05), respectively. More PA and less SED were significantly associated with lower cylinder power (p < 0.05), respectively. More PA and less SED were significantly associated with lower risks of myopia and astigmatism, respectively (p < 0.05). Conclusions: PA and SED were associated with the risk of refractive error. Maintaining a healthy lifestyle can help to reduce the risk of refractive error in boys and girls.

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