The effect of melatonin on lipid peroxide oxidation, oxidative modification of proteins and mitochondria swelling in the skeletal muscle tissue of rats under alloxan diabetes

Gerush, I. V.; Bevzo, V. V.; Ferenchuk, Ye. O.

doi:10.15407/ubj90.03.062

Cited by 7 publications

(6 citation statements)

References 22 publications

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“…Increased TBA-positive products in blood leukocytes of diabetic animals indicates the activation of lypoperoxidation processes during experimental DM. Disruption of membrane structural-functional integrity, as a consequence of LPO, causes a decreased membrane potential, distortion of transmembrane phospholipid asymmetry and activity of membrane-bound enzymes, receptors and transmembrane proteins and reduced regulatory effect of hormones and mediators [ 67 , 68 ]. As a result, the functional activity of leukocytes is altered, which becomes a contributor to DM complications [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

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Agmatine prevents oxidative-nitrative stress in blood leukocytes under streptozotocin-induced diabetes mellitus

et al. 2019

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Changes in cellular metabolism, development of oxidative-nitrative stress and intensification of glycation and lipid peroxidation (LPO), are significant processes that occur during diabetes mellitus (DM)-associated chronic hyperglycemia. These processes contribute to deviations in the structural organization and functional activity of leukocytes. The development of oxidative-nitrative stress in peripheral blood cells during DM can be prevented by agmatine, an endogenous metabolite of L-arginine, which is a nitric oxide synthase (NOS) inhibitor, and possesses hypoglycemic properties. The administration of agmatine to animals with DM lead to the inhibition of both constitutive and inducible NOS in leukocytes, which in turn decreased total nitrite/nitrate (NOx) levels. Additionally, we observed corresponding increases in reduced glutathione content and activity of antioxidant enzymes (SOD, CAT, GPx, GR), along with decreased levels of the thiobarbituric acid reactive substance, advanced oxidation protein products (AOPPs) and advanced glycosylation end-products (AGEs) as compared to the non-treated diabetic group. Our results indicate that treatment of diabetic animals with agmatine restores redox homeostasis and a balances antioxidant defence system enzymes in leukocytes. This corrective effect on the functional capacity of leukocytes is exerted by preventing oxidative-nitrative stress in animals with DM.

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Section: Discussionmentioning

confidence: 99%

“…Subsequently, oxidized glutathione (GSSG) undergoes reduction by NADPH-dependent GR. Formed NADP + is then restored in the first and third reactions of the pentose phosphate pathway, as well as by the cytochrome chain and a system of natural antioxidants: α-tocopherol, ascorbic acid and flavonoids [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

Agmatine prevents oxidative-nitrative stress in blood leukocytes under streptozotocin-induced diabetes mellitus

et al. 2019

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“…Aldehyde-or ketone derivatives of a neutral or main character with different ranges of absorption spectrum are known to result from protein oxidation depending on amino acids of a neutral or main character prevailed in their molecules. With =370 nm ketonodinitrophenylhydrazones of a neutral character are determined, with =430 nm -aldehydodinitrophenylhydrazones of the main character 15 . The content of POM was expressed in the units/g of tissue.…”

Section: Methodsmentioning

confidence: 99%

Protein peroxide oxidation in the cerebral cortex and hippocampus of rats with Type 2 diabetes mellitus, under carbacetam effect

Kmet¹,

Filipets²,

HRACHOVA³

et al. 2019

Arch Balk Med Union

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“…Melatonin is a powerful antioxidant substance and also has protective effects on the mitochondria [12][13][14][15]. A study showed beneficial effects on plasma MDA, GSH, PCO, and NO levels after the administration of 5 mg of melatonin (twice a day) for 12 weeks in diabetic patients [15].…”

Section: Antioxidant and Free Radical Scavenger Activity Of Melatoninmentioning

confidence: 99%

Melatonin in Cardiovascular Diseases

Kara¹,

Kara²

2022

Melatonin - Recent Updates

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Melatonin is an endocrine product released from the gland known as the pineal gland and is predominantly secreted during the night. Light exerts an inhibitory effect on melatonin secretion in the pineal gland. The suprachiasmatic nucleus controls pineal melatonin synthesis and its release via the peripheral sympathetic nervous system, which includes synapses in the intermediolateral cell column of the thoracic cord and its projection toward the superior cervical ganglia. Melatonin regulates many physiological functions in the body through membrane receptors and nuclear binding sites. In a chick study, the presence of melatonin receptors in cardiomyocytes was reported and, in another study, MT1 and MT2 membrane receptors were identified in left ventricular cardiomyocytes of the human heart. For this reason, it is suggested that melatonin has some regulatory effects on the cardiovascular system. Ischemic heart disease and myocardial infarctions are the main cause of cardiovascular death. Studies have shown that melatonin applications reduce the amount of blood cholesterol, LDL, and triglyceride and increase the amount of HDL. In light of these data, it can be said that melatonin is an important cardiovascular system protector. In this chapter, the protective effects and mechanisms of melatonin on the cardiovascular system will be discussed.

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The effect of melatonin on lipid peroxide oxidation, oxidative modification of proteins and mitochondria swelling in the skeletal muscle tissue of rats under alloxan diabetes

Cited by 7 publications

References 22 publications

Agmatine prevents oxidative-nitrative stress in blood leukocytes under streptozotocin-induced diabetes mellitus

Agmatine prevents oxidative-nitrative stress in blood leukocytes under streptozotocin-induced diabetes mellitus

Protein peroxide oxidation in the cerebral cortex and hippocampus of rats with Type 2 diabetes mellitus, under carbacetam effect

Melatonin in Cardiovascular Diseases

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