Introduction: Pregnancy is the golden period to prepare children for the future. Stimulation is needed during pregnancy, one of which is brain stimulation. This can be done with Al Qur'an Murrotal Surah Ar-Rahman stimulation. This study aims to analyze expression of synapsin 1 in the cerebrum of newborn Rattus norvegicus when given murrotal Surah Ar-Rahman stimulation by qari, qariah, and not given any stimulation during pregnancy.Methods: Experimental with post-test only control group design. Sampling in this study was considered homogeneous because it met the inclusion criteria. The samples obtained were distributed randomly to each experimental group and randomized into 3 groups, including control group, group stimulated by qari, and group stimulated by qariah. The treatment was given on the 6 th day of pregnancy for 1 hour in a soundproof room with an intensity of 65 dB.
Results:The highest mean expression of synapsin 1 in the cerebrum is qari group (6.96 ± 2.59), then qariah group (5.84 ± 2.90), and the lowest is control group (5.74 ± 2.32). There is no significant difference in expression of synapsin 1 in the cerebrum between control and qari groups (p = 0.306), control and qariah groups (p = 0.932), qari and qariah groups (p = 0.347).
Conclusion:The highest expression of Synapsin 1 in the cerebrum of newborn Rattus norvegicus is the group stimulated by qari.