The effect of n‐acetyl‐cysteine on recovery of the facial nerve after crush injury

Rivera, Andrew; Raymond, Mallory; Grobman, Ariel; Abouyared, Marianne; Angeli, Simón I.

doi:10.1002/lio2.68

Cited by 13 publications

(7 citation statements)

References 20 publications

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“…Moreover, AA may also have other functions beside the building of proteins, such as antioxidants or participate in the chain of neurotransmission. For instance, in a rat model of facial nerve crush injury systemic administration of n-acetylcysteine (a potent antioxidant) favored nerve recovery as shown by improved functional and electromyography outcomes (Rivera et al, 2017). AA can be utilized to synthesize both lipids and glucose.…”

Section: Discussionmentioning

confidence: 99%

Oral Aminoacids Supplementation Improves Corneal Reinnervation After Photorefractive Keratectomy: A Confocal-Based Investigation

Roszkowska

Rusciano²,

Severo

et al. 2021

Front. Pharmacol.

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Aim of this retrospective study was to estimate the effect of oral supplementation with amino acids (AA) on corneal nerves regrowth after excimer laser refractive surgery with photorefractive keratectomy (PRK). Based on the pre and post-surgical treatment received, 40 patients with 12 months of follow-up were distributed in two groups: 20 patients had received oral AA supplementation 7 days before and 30 days after PRK, and 20 patients without AA supplementation, as untreated reference control. All patients followed the same standard post-operative topical therapy consisting of an association of antibiotic and steroid plus sodium hyaluronate during the first week, then steroid alone progressively decreasing during 30 days and sodium hyaluronate for the following 3 months. In vivo corneal confocal microscopy was used to evaluate the presence of sub-basal corneal nerve fibers during 12 months after PRK. Results have shown that sub-basal nerves regenerated significantly faster (p <0.05), and nerve fibers density was significantly higher (p <0.05) with a more regular pattern in the eyes of AA treated patients with respect to the untreated control group. Therefore, our data indicate that oral supplementation with AA improved significantly corneal nerve restoration after PRK and could thus be considered as an additional treatment during corneal surgical procedures.

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Section: Discussionmentioning

confidence: 99%

Oral Aminoacids Supplementation Improves Corneal Reinnervation After Photorefractive Keratectomy: A Confocal-Based Investigation

Roszkowska

Rusciano²,

Severo

et al. 2021

Front. Pharmacol.

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show abstract

“…On the day of surgery, before animals were anesthetized, a saline drop was placed from a pipet onto the right eye to determine the presence of the blink reflex [12] .…”

Section: Preoperative Assessmentmentioning

confidence: 99%

“…A pre-auricular incision with a marginal mandibular extension was made on the right side of the face to expose the trunk of facial nerve [15] . The trunk of FN was crushed for 1 minute via a hemostatic mosquito clamp to three clicks (Figure 1) [12] .…”

Section: Surgical Procedurementioning

confidence: 99%

“…Included eight rats which intraperitoneally injected with NAC at a dose of 50 mg/kg/day for a period of 28 days after nerve crushing [12] .…”

Section: Group Ii: (Study Group I)mentioning

confidence: 99%

“…Functional testing was made at the day after operation. During 28 days the rats were tested at 2 and 4 weeks postoperatively [12] .…”

Section: Postoperative Assessmentmentioning

confidence: 99%

See 2 more Smart Citations

Regenerative Impact (Capacity) of Cerebrolysin versus N-Acetyl- Cysteine on Facial Nerve injury in Rats

Aldheeb

Haggag

EL-Zehary

et al. 2020

OMX

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Management of FN injury in the present time focuses on that may or may not heal spontaneously [6] . The development in microsurgery, microbiology, radiographic imaging and electro-diagnostic testing has provided great vision into the treatment, diagnosis, pathophysiology and rehabilitation of FN. The proper diagnosis and early treatment is the most important principle for all physicians in management of FN pathology [5] .However, the treatment with surgical intervention is essential in injuries associated with immediate complete paralysis, which are unlikely to have spontaneous recovery, because of the presumed neuronal disorder [6] .Many therapeutic agents (such as: steroids, nimodipine, oxytocin...etc.) have been suggested for years to improve neural function and shorten recovery period, and investigations still go on [7,8] .

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A biomaterials approach to Schwann cell development in neural tissue engineering

Lotfi

Khakbiz

Moghaddam

et al. 2019

J Biomedical Materials Res

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Schwann cells, in addition to forming myelin sheaths, have pivotal roles in regeneration of injured axons in the peripheral nervous system such as producing a natural permissive conduit between distal and proximal stumps and secreting nerve growth factors. Due to the atrophy and senescence of Schwann cells in long nerve gap, and the need to ensure the presence of nerve growth factors and basal lamina tubes for axon regeneration in a critical time, injection of Schwann cells with the aid of an engineered conduit seems to be an effective approach to induce axon regrowth. Stem cells with high differentiation and proliferation capability can provide an adequate number of Schwann cells in healthy state for regeneration purposes. Guidance of stem cells differentiation into desired lineages, control of implanted Schwann cells fate, maintenance of nerve growth factors expression, and guidance of axon regrowth are possible with the aid of biomaterials with appropriate chemical, physical, and mechanical properties. Biomaterials' surface chemistry and biomolecules interacting with cells' receptors initiate specific intracellular signaling cascades and direct cells fate. In addition, biomaterials' surface topography in association with cells contact area, focal adhesion, and cytoskeletal remodeling by mechanotransduction process influences cells behavior and induces specific differentiation. The main objective of this review is to investigate the chemical, topographical, and mechanical properties of biomaterials which influence the fate of Schwann cells and the nerve regeneration process.

show abstract

The effect of n‐acetyl‐cysteine on recovery of the facial nerve after crush injury

Cited by 13 publications

References 20 publications

Oral Aminoacids Supplementation Improves Corneal Reinnervation After Photorefractive Keratectomy: A Confocal-Based Investigation

Oral Aminoacids Supplementation Improves Corneal Reinnervation After Photorefractive Keratectomy: A Confocal-Based Investigation

Regenerative Impact (Capacity) of Cerebrolysin versus N-Acetyl- Cysteine on Facial Nerve injury in Rats

A biomaterials approach to Schwann cell development in neural tissue engineering

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