2017
DOI: 10.1080/21691401.2017.1282869
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The effect of pPolyHb on hemodynamic stability and mesenteric microcirculation in a rat model of hemorrhagic shock

Abstract: The effects of polymerized porcine hemoglobin (pPolyHb) on hemodynamic stability and maintenance of mesenteric microvascular function were explored in a rat model of hemorrhagic shock (HS). Following controlled hemorrhage, rats were infused with equal volumes of either pPolyHb, hetastarch (HES), or red blood cell (RBC). The results showed that pPolyHb was superior to HES and RBC in restoring hemodynamic stability and reversing anaerobic metabolism. We observed a reduction in the diameter of mesenteric microvas… Show more

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Cited by 3 publications
(4 citation statements)
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“…Our new type of oxygen-carrying plasma can be used for the treatment of severe acute pancreatitis through the mechanism of HES by improving intestinal oxygen metabolism, reducing the release of inflammatory mediators, and protecting the integrity of the intestinal barrier. Reducing the body's oxidative stress and inflammation while reducing the translocation of intestinal bacteria, combined with PolyHb, can increase the oxygen supply of the intestinal mucosa and other important organs and its synergistic effect in improving the mesenteric microcirculation 19,20 . This process prevents further development of severe acute pancreatitis, thereby reducing the occurrence of MOF, which is an important step in the treatment of severe acute pancreatitis.…”
Section: Discussionmentioning
confidence: 99%
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“…Our new type of oxygen-carrying plasma can be used for the treatment of severe acute pancreatitis through the mechanism of HES by improving intestinal oxygen metabolism, reducing the release of inflammatory mediators, and protecting the integrity of the intestinal barrier. Reducing the body's oxidative stress and inflammation while reducing the translocation of intestinal bacteria, combined with PolyHb, can increase the oxygen supply of the intestinal mucosa and other important organs and its synergistic effect in improving the mesenteric microcirculation 19,20 . This process prevents further development of severe acute pancreatitis, thereby reducing the occurrence of MOF, which is an important step in the treatment of severe acute pancreatitis.…”
Section: Discussionmentioning
confidence: 99%
“…18 As the functional diffusion distance between red blood cells and endothelium is reduced, oxygenation is allowed even in areas of vascular stenosis or vasoconstriction where red blood cells cannot penetrate. 19,20 Therefore, this function may prevent the progression of tissue necrosis. In addition, compared with normal human hemoglobin, HBOC has a lower affinity for oxygen, which improves tissue oxygenation.…”
Section: Characteristics Of Hbocsmentioning
confidence: 99%
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