The Effect of Tender Coconut Water on Free Radical Due to Mercury Exposure

Abstract

<span lang="EN-US">Mercury pollution can results from gold mining. Furthermore, a continuous mercury exposure can trigger the formation of Reactive Oxygen Species (ROS) and interfere with the body's antioxidant metabolism. A high level of free radicals in the body can be characterized by a low level of an antioxidant enzyme. Prevention to avoid the impacts of mercury poisoning is better than treatment. Tender coconut water can eliminate ROS and improve antioxidant status. This study aimed to was to confirm that tender coconut water is able to decrease the free radical which is characterized by increased antioxidant enzyme GPx status. This study was designed as randomized pre- and posttest control group design<em>,</em> 40 traditional gold mining workers devided into 2 groups: the control and treatment groups. After the pre test of GPx level, the workers were either given tender coconut water at the dose of 450 m L or water for 4 weeks every day. Four weeks after the pre-test, the level of GPx was assessed in the laboratory PAU-Gajahmada University. The post test results of the control group and treatments group were compared and analyzed using <em>Man Whitney test</em>. The mean levels of GPx post-test in the control group and treated group were 63.5±1.1 U/mL and 79.9±8.8 U/mL respectively. The analysis result obtained p-value 0.000 <0.05. Tender coconut water has an effect on free radicals due to to mercury exposure. Tender coconut water can be consumed daily to prevent degenerative diseases caused by mercury exposure.</span>

Tender Coconut Water Inhibits the Process of Lipid Peroxidation, Reduce Glucose Levels and Increase Plasma Insulin in Pregnant Diabetic Rats

“…GSH will be oxidized to oxidized glutathione (GSSG) by the enzyme glutathione peroxidase (GPx), GSSG will be rereduced to form GSH by the glutathione reduktese enzyme (Grade) by involving NADPH as an electron donor. 25 Vitamin E (α-tocopherol) is a lipid-soluble vitamin which acts as a lipid peroxyl radical scavenger, preventing lipid peroxidation chain reactions in the cell membranes. 26 Arginine supplementation has been shown to be a promising method of improving cardiovascular function type II diabetes by increasing endothelial NO synthesis.…”

Effect of Tender Coconut Water to Prevent Anemia on Wistar Rats Induced by Lead (Plumbum)

“…Natural antioxidants can protect the body against cell damage caused by ROS. 22 Foods containing natural antioxidants can be used as a strategy to reduce morbidity and mortality especially due to the oxidative stress. 7 Coconut water is a natural, healthy, nutritious drink that contains antioxidants substances such as minerals (Cu, Zn, Mn), Vitamin C, and L-argininee.…”

“…11 Tender coconut water to prevent oxidative stress, reduce free radicals, increase Antioxidant Enzym, decrease lipid peroxidative. 7,11,[22][23][24] The result of this study indicate that tender coconut water at a dose of 8 mL/200 gBW is significantly increased hemoglobin, hematocrit and erythrocyte levels in male wistar strain rats induced by Pb, these results are linear with previous research by Jesuorsemwen et al that the mean hematocrit and erythrocyte levels increased in the administration of tender coconut water, 25 the results of other research conducted by Safitri et al stated that the administration of tender coconut water can increase the mean of blood hemoglobin level. 26 Fa'iza et al stated that there were differences in blood Hemoglobin level before and after consumption of green coconut water in workers exposed to lead (Pb) with p value = 0.001.…”

Pengaruh Pemberian Air Kelapa Muda Terhadap Kadar Ureum Pada Tikus Galur Wistar Yang Terpapar Plumbum (Pb)

“…(3) Penelitian terbaru menunjukkan bahwa air kelapa muda kaya akan sumber asam amino bebas L-arginin dan vitamin C, yang dapat mencegah penyakit jantung dan mencegah terjadinya peroksidasi lipid serta stres oksidatif. (6), (7) L-arginin dapat digunakan untuk terapeutik dan dapat mengurangi efek keracunan logam berat. (8) Penelitian ini bertujuan untuk membuktikan adanya Efek Air kelapa Muda terhadap Kadar Ureum pada Tikus Galur Wistar yang terpapar Plumbum (Pb).…”

“…(15) Peran vitamin C bekerja secara sinergi dengan vitamin E dalam menghambat proses peroksidasi lipid. (7) Mineral Cu, Zn, dan Mn yang terdapat di dalam air kelapa muda dapat digunakan sebagai sumber mineral dan kofaktor antioksidan SOD yang terdapat dalam tubuh, kekurangan mineral tersebut dapat menurunkan aktifitas antioksidan SOD. (8)…”