The effect of visible blue light on the differentiation of dendritic cells in vitro

Monfrecola, Giuseppe; Lembo, Serena; Cantelli, Mariateresa; Ciaglia, Elena; Scarpato, Luigi; Fabbrocini, Gabriella; Balato, Anna

doi:10.1016/j.biochi.2014.02.001

Cited by 17 publications

(17 citation statements)

References 16 publications

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“…Therefore, the effects of blue light observed here could be explained by effects observed in vitro, like inhibition of keratinocyte proliferation, increased keratinocyte differentiation and/or increased apoptosis of T cells [5]. Additionally, blue light has been shown to inhibit cytokine production by dendritic cells [18], which could also play a role for reducing Pv symptoms. The results of the present clinical study are also in line with a previous trial comparing blue and red light to treat Pv.…”

Section: Discussionmentioning

confidence: 99%

Prospective Randomized Long-Term Study on the Efficacy and Safety of UV-Free Blue Light for Treating Mild Psoriasis Vulgaris

Pfaff

Liebmann²,

Born³

et al. 2015

Dermatology

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Background: Blue light irradiation reduces the proliferation of keratinocytes and modulates T-cell immune response in vitro and has been shown to reduce the severity of psoriasis vulgaris (Pv) in two clinical trials. Objective: Evaluation of safety and efficacy of long-term UV-free blue light treatment at home for mild Pv. Methods: Forty-seven patients with mild Pv were randomized for receiving high-intensity blue light treatment (HI: 453 nm LED, 200 mW/cm², n = 24) and low-intensity treatment (LI: 453 nm LED, 100 mW/cm², n = 23) of one Pv plaque for 12 weeks. A contralateral control plaque remained untreated. Results: Patient compliance and satisfaction were high. The primary endpoint, change from baseline (CfB) of the Local Psoriasis Severity Index, revealed a significant improvement of the target compared to the control plaques (ΔCfB for the HI group: -0.92 ± 1.10, p = 0.0005; for the LI group: -0.74 ± 1.18, p = 0.0064). Conclusion: UV-free blue light home treatment is safe and improves Pv plaques.

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Section: Discussionmentioning

confidence: 99%

Prospective Randomized Long-Term Study on the Efficacy and Safety of UV-Free Blue Light for Treating Mild Psoriasis Vulgaris

Pfaff

Liebmann²,

Born³

et al. 2015

Dermatology

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“…The investigators observed that blue light did not affect cell viability but only suppressed cell activation and subsequently reduced their allogeneic stimulatory potential. In another study, Monfrecola et al reported that blue light (400–500 nm, up to 15 J/cm 2 ) did not interfere with the differentiation and maturation of dendritic cells, whereas it was effective in reducing the production of IL-6 and TNF-a, pro-inflammatory cytokines (Monfrecola et al, 2014). …”

Section: Effect Of Antimicrobial Blue Light On Host Cells and Tissuesmentioning

confidence: 99%

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

Wang

et al. 2017

Drug Resistance Updates

227

192

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As an innovative non-antibiotic approach, antimicrobial blue light in the spectrum of 400–470 nm has demonstrated its intrinsic antimicrobial properties resulting from the presence of endogenous photosensitizing chromophores in pathogenic microbes and, subsequently, its promise as a counteracter of antibiotic resistance. Since we published our last review of antimicrobial blue light in 2012, there have been a substantial number of new studies reported in this area. Here we provide an updated overview of the findings from the new studies over the past 5 years, including the efficacy of antimicrobial blue light inactivation of different microbes, its mechanism of action, synergism of antimicrobial blue light with other angents, its effect on host cells and tissues, the potential development of resistance to antimicrobial blue light by microbes, and a novel interstitial delivery approach of antimicrobial blue light. The potential new applications of antimicrobial blue light are also discussed.

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“…Furthermore, as in photopheresis, apoptotic bodies induced by TMA treatment with BL and UVA light, and the following antigen presentation by dendritic cells (DCs), could modulate the immune system, increasing the photoantiproliferative effect. It must be also noted that, despite UVA light, BL irradiation (2.5 J/cm 2 ) does not impair the in vitro differentiation and maturation of human monocyte‐derived DCs and reduces the production of pro‐inflammatory cytokines …”

Section: Discussionmentioning

confidence: 99%

4,6,4′‐trimethylangelicin shows high anti‐proliferative activity on DU145 cells under both UVA and blue light

et al. 2018

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The effect of visible blue light on the differentiation of dendritic cells in vitro

Cited by 17 publications

References 16 publications

Prospective Randomized Long-Term Study on the Efficacy and Safety of UV-Free Blue Light for Treating Mild Psoriasis Vulgaris

Prospective Randomized Long-Term Study on the Efficacy and Safety of UV-Free Blue Light for Treating Mild Psoriasis Vulgaris

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

4,6,4′‐trimethylangelicin shows high anti‐proliferative activity on DU145 cells under both UVA and blue light

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