The Effect of Vitamin D3 Supplementation on Hepcidin, Iron, and IL-6 Responses after a 100 km Ultra-Marathon

Kasprowicz, Katarzyna; Ratkowski, Wojciech; Wołyniec, Wojciech; Kaczmarczyk, Mariusz; Witek, Konrad; Żmijewski, Piotr; Renke, Marcin; Jastrzębski, Zbigniew; Rosemann, Thomas; Nikolaidis, Pantelis Theodoros; Knechtle, Beat

doi:10.3390/ijerph17082962

Cited by 18 publications

(22 citation statements)

References 51 publications

(71 reference statements)

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“…From the articles that evaluated ultra-marathon running, four studies (Drenth et al, 1995 ; Donnikov et al, 2009 ; Gill et al, 2015a ; Benedetti et al, 2021 ) evaluated distances in the ranges of 51–86, 51–81, 122–208, and 99–218 km respectively, two studies (Mastaloudis et al, 2004 ; Díaz-Castro et al, 2012 ) 50 km distance, one study (Sansoni et al, 2017 ) 65 km distance, one study (Nieman et al, 2002 ) 80 km distance, one study (Peters et al, 2001 ) 90 km distance, four studies (Chiu et al, 2013 ; Czajkowska et al, 2020 ; Kasprowicz et al, 2020 ; Wołyniec et al, 2020 ) evaluated 100 km, four studies (Nieman et al, 2003 , 2005 , 2006 , 2007 ) evaluated 160 km, one study (Roupas et al, 2013 ) evaluated 180 km, one study (Kim et al, 2007 ) evaluated 200 km, one study (Gill et al, 2015b ) evaluated 230 km and one study (Shin and Lee, 2013 ) evaluated 308 km. Some studies that evaluated the ultra-marathons presented particularities in relation to the topography characteristic.…”

Section: Resultsmentioning

confidence: 99%

“…Four studies on trails with the varying ground (Mastaloudis et al, 2004 ; Roupas et al, 2013 ; Gill et al, 2015a , b ). Five studies with flat ground, including athletics tracks (Chiu et al, 2013 ; Czajkowska et al, 2020 ; Kasprowicz et al, 2020 ; Wołyniec et al, 2020 ; Benedetti et al, 2021 ), the other studies did not identify the running ground.…”

Section: Resultsmentioning

confidence: 99%

“…The most evaluated cytokine was IL-6 found in 62 studies (Drenth et al, 1995 ; Castell et al, 1996 ; Ostrowski et al, 1998 , 1999 , 2000 ; Neidhart et al, 2000 ; Suzuki et al, 2000 , 2003 ; Toft et al, 2000 ; Nieman et al, 2001 , 2002 , 2003 , 2005 , 2006 , 2007 ; Starkie et al, 2001 ; Bonsignore et al, 2002 ; Pistilli et al, 2002 ; Uchakin et al, 2003 ; Mastaloudis et al, 2004 ; Miles et al, 2006 ; Kim et al, 2007 ; Siegel et al, 2007 ; Ng et al, 2008 ; Donnikov et al, 2009 ; Cox et al, 2010 ; Howatson et al, 2010 ; Scherr et al, 2011 , 2012 ; Díaz-Castro et al, 2012 ; Nickel et al, 2012 ; Vaisberg et al, 2012 , 2013 ; Abbasi et al, 2013 ; Bernecker et al, 2013 ; Chiu et al, 2013 ; Reihmane et al, 2013 ; Santos et al, 2013a , 2016 ; Shin and Lee, 2013 ; Wilhelm et al, 2014 ; Gill et al, 2015a , b ; Luna Junior et al, 2016 ; Niemelä et al, 2016 ; Zimmer et al, 2016 ; Clifford et al, 2017 ; Passos et al, 2019 ; Pugh et al, 2019 ; Sierra et al, 2019a , b ; Yargic et al, 2019 ; Batatinha et al, 2020 ; Costello et al, 2020 ; dos Santos et al, 2020 ; Kasprowicz et al, 2020 ; Larsen et al, 2020 ; Wołyniec et al, 2020 ...…”

Section: Resultsunclassified

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Changes in Cytokines Concentration Following Long-Distance Running: A Systematic Review and Meta-Analysis

et al. 2022

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Long-distance running is an exhausting effort for the whole organism. Prolonged aerobic exercise induces changes in inflammatory markers. However, predicting muscle damage in response has limitations in terms of selecting biomarkers used to measure inflammatory status. The present study conducts a systematic review and meta-analysis of articles focusing in ultra-marathon, marathon, and half-marathon and levels of cytokines. The search was conducted in PubMed, Web of Science, and Scopus databases, resulting in the inclusion of 76 articles. IL-6 was highlighted, evaluated in 62 studies and show increase in the standard mean difference (SMD): half-marathon (SMD −1.36; IC 95%: −1.82, −0.89, Ch2:0.58; tau2:0.00; p < 0.0001), marathon (SMD −6.81; IC 95%: −9.26, −4.37; Ch2:481.37 tau2:11.88; p < 0.0001) and ultra-marathon (SMD −8.00 IC 95%: −10.47, −5.53; Ch2:328.40; tau2:14.19; p < 0.0001). In contrast meta-regression analysis did not show relationship to the running distance (p = 0.864). The meta-analysis evidenced increase in the concentration of IL-1ra (p < 0.0001), IL-1B (p < 0.0001), IL-8 (p < 0.0001), IL-10 (p < 0.0001) and TNF-α (p < 0.0001). Reduction in IL-2 (p < 0.0001) and INF-y (p < 0.03) and no change in the IL-4 (p < 0.56). The number of studies evaluating the effect of adipokines was limited, however Leptin and Resistin were recurrent. The effects of an acute bout of prolonged aerobic exercise will protect against chronic systemic inflammation. The time to return to baseline values showed a substantial and dose-dependent relationship with run volume. The concentration of IL-6 was robustly studied and the marathon running was the most explored. Network of endocrine interactions in which circulating factors, released in extreme exercises, interplay through inter-organ crosstalk and physiologic changes were expressed. The running volume variability was able to modulate compounds that play a fundamental role in the maintenance of homeostasis and cell signaling.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsunclassified

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Changes in Cytokines Concentration Following Long-Distance Running: A Systematic Review and Meta-Analysis

et al. 2022

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“…In contrast, Kasprowicz et al, (2020) reported that both an excess and a deficiency of vitamin D can be detrimental to the selected health indices; therefore, future studies are needed to explore the association between the various doses of vitamin D3 supplementation and iron metabolism in athletes.…”

Section: Resultsmentioning

confidence: 98%

Alveolar gene expression of tight junction protein in nicotine rats treated with zinc and vitamin D

Hamady

Al-Okaily

2022

ijhs

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The current study aimed to investigation the role of zinc and vitamin D in modulating alveolar response of nicotine stress as a model of mammals male Wistar rats. Thirty mature males werekept at 23 ± 2 C°, randomly assigned to five equal groups and treatment for 14 days, C = Control drenched vehicle without treatment, G1 = injected with i/p nicotine 1.5 mg/ kg b.w., G2 = administrated orally of zinc 60 mg/ kgb.w., G3 = administrated orally of vitamin D 250 µg/ kg b.w., G4 = administrated orally both of zinc and vitamin D with same doses stressed and nicotine 1.5 mg/ kgb.w.i/p. Rats were anesthetized with ketamine at the end of the treatment period with xylazine and blood samples have been collected from the optical vein for estimation of serum ferritin and transferrin, then animals were sacrificed and lung was removed and weighted.All groups of rats had lung samples extracted rapidly, dipped in DEPC solution, and frozen under liquid nitrogen for determination of tight junction protein ( TJP) gene expression by RT-PCR analyses. Nicotine-stressed rats treated with zinc and vitamin D (G4) havesignificant highly increased expression of alveolar tight junction protein when compared with nicotine group (G1).

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“…According to research, vitamin D 3 has a significant, beneficial effect on iron levels. In this way, it prevents the iron deficiency anemia that often affects athletes (Kasprowicz et al, 2020). In addition, a negative correlation has been noted regarding vitamin D 3 levels and markers of muscle damage.…”

Section: Factors Influencing Recovery and The Risk Of Injurymentioning

confidence: 96%

The Consequences of Training and Competition to the Musculoskeletal System in Ultramarathon Runners: A Narrative Review

Partyka

Waśkiewicz

2021

Front. Physiol.

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Ultramarathons are becoming increasingly popular every year, leading to more and more publications focusing on athletes of these endurance events. This paper summarizes the current state of knowledge on the effects of ultramarathons on the motor system. Various studies have attempted to answer questions about negative and positive effects on the musculoskeletal system, common injuries, optimal strategies, and regeneration. Considering the increasing number of ultramarathon athletes, the discoveries may have practical applications for a multitude of experts in the field of sports medicine, as well as for the athletes themselves. Acute locomotor system changes in runners as assessed by locomotor biomarkers are reversible and may be asymptomatic or painful. Injuries suffered by runners largely allow them to finish the competition and are usually overlooked. Regeneration, including regular massage and the use of supporting techniques, allows for faster convalescence. This publication is meant to be a source of knowledge for people associated with this discipline.

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The Effect of Vitamin D3 Supplementation on Hepcidin, Iron, and IL-6 Responses after a 100 km Ultra-Marathon

Cited by 18 publications

References 51 publications

Changes in Cytokines Concentration Following Long-Distance Running: A Systematic Review and Meta-Analysis

Changes in Cytokines Concentration Following Long-Distance Running: A Systematic Review and Meta-Analysis

Alveolar gene expression of tight junction protein in nicotine rats treated with zinc and vitamin D

The Consequences of Training and Competition to the Musculoskeletal System in Ultramarathon Runners: A Narrative Review

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