The Effectiveness of Adding Probiotic on Antimicrobial for Bacterial Vaginosis: A Systematic Review

Darmayanti, Aquartuti Tri; Murti, Bhisma; Susilawati, Tri Nugraha

doi:10.26911/theijmed.2017.02.03.03

Cited by 8 publications

(10 citation statements)

References 15 publications

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“…Each probiotic strain is a specific strain that the outcome depends on the type and dose of probiotics given. 9 In terms of probiotics, various factors can affect the results of studies. The mechanism of action of probiotic bacteria is highly dependent on the strain of the bacterium.…”

Section: Discussionmentioning

confidence: 99%

“…Several trial studies also found that strains of G. vaginalis and other anaerobic bacteria begin to experience resistance to metronidazole in recurrent BV cases. 9,10 Some studies reported the side effects of metronidazole and clindamycin. Metronidazole has been reported to cause gastrointestinal disorders such as nausea and vomiting, metallic taste in the mouth, paresthesia, and leukopenia.…”

Section: Introductionmentioning

confidence: 99%

“…Many studies have considered probiotics as additional alternative therapies for BV. 9 Probiotics are living microorganisms. If they are given in sufficient quantities, they will provide beneficial health effects to the host.…”

Section: Introductionmentioning

confidence: 99%

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The Efficacy of Lactobacillus plantarum as Adjunctive Therapy of Bacterial Vaginosis: A Double-blind, Randomized, Placebo-controlled Trial

Widiatma

Listiawan

Murtiastutik

et al. 2020

BIKK

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Background: Bacterial vaginosis (BV) is a clinical syndrome caused by the changing of Lactobacillus spp., a producer of hydrogen peroxide, in the normal vagina with a high concentration of anaerobic bacteria, Gardnerella vaginalis and Mycoplasma hominis. This study reports a resistance of BV therapy regimens, high recurrence rates, and side effects of an antibiotic. Therefore, adjunctive therapy for BV management is needed. Research has reported the therapeutic effects of probiotic in BV; however, the results are inconsistent. Purpose: To evaluate the efficacy of standard therapy using metronidazole and Lactobacillus plantarum for BV measured by the cure rate and vaginal flora balance. Methods: A randomized, double-blind, placebo-controlled trial, 30 subjects were randomized to take metronidazole 500 mg twice a day for seven days with weekly evaluation. The Lactobacillus plantarum or placebo group was evaluated every 4 weeks. The cure rate and vaginal flora balance were evaluated using the Amsel criteria and Nugent score before and after the intervention. Result: A total of 30 subjects returned for 28-day follow-up, of which 60% subjects of the antibiotic/probiotic group were cured compared to 40% in the antibiotic/placebo group (p>0.05). Conclusion: There was no difference in the increase of cure rate and vaginal flora balance between the treatment group and significant control group.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Efficacy of Lactobacillus plantarum as Adjunctive Therapy of Bacterial Vaginosis: A Double-blind, Randomized, Placebo-controlled Trial

Widiatma

Listiawan

Murtiastutik

et al. 2020

BIKK

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“…Bakteri vaginosis (BV) adalah suatu kondisi yang ditandai dengan penurunan jumlah microbiota Lactobacillus spp. dan diikuti oleh peningkatan jumlah bakteri lain seperti Gardnerella vaginalis, Atopobium vaginae, Prevotella spp., Mobilucus spp, dan Mycoplasma hominis (Krauss-Silva et al, 2011;Darmayanti et al, 2017). Komplikasi BV pada kehamilan termasuk, ketuban pecah dini, postpartal endometritis, meningkatkan kegagalan dalam perkembangan kehamilan, dan kelahiran prematur (Vujic et al, 2013;Tri Darmayanti et al, 2019).…”

Section: Hasil Dan Pembahasan 1 Probiotik Untuk Bakterial Vaginosis Pada Kehamilanunclassified

“…Efek H2O2 pada bakteri patogen bergantung pada kemampuan pengoksidasi dinding sel bakteri. H2O2 bekerja bersamaan dengan asam organik lainnya untuk mengatasi bakteri patogen seperti: Listeria monocytogenes, Bacillus cereus, Bacillus subtilis, Yersinia enterocolitica, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, Gardnerela vaginalis dan Klebsiella pneumoniae (Hou et al, 2015;Jandhyala et al, 2015;Darmayanti et al, 2017).…”

Section: Hasil Dan Pembahasan 1 Probiotik Untuk Bakterial Vaginosis Pada Kehamilanunclassified

Probiotik Untuk Kehamilan : A Review

Handayani¹,

Mustofa

Puspita

et al. 2020

avicenna

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Kesehatan sistem pencernaan selama kehamilan mengambil peranan penting dalam proses metabolisme, pemrograman imunologis janin dan menyuplai nutrisi bagi ibu dan janin. Atas dasar ini, mikrobiota usus ibu dianggap berkontribusi terhadap terhadap kesehatan ibu dan janin. Penggunaan probiotik adalah salah satu metode yang dapat digunakan untuk memelihara kesehatan usus, mengaktivitasi mikrobiota agar dapat bermanfaat untuk imunitas, mencegah gangguan atopik, bakterial vaginosis, diabetes mellitus gestasional (GDM) dan hipertensi pada kehamilan. Tujuan: Mengulas manfaat probiotik untuk kehamilan dan kesehatan wanita. Metode: Review ini dilakukan penulis dengan menelusuri database diantaranya PubMed, Google scholar, dan open access science direct untuk mengetahui potensi studi yang memenuhi syarat. Kata kunci yang digunakan antara lain: 'Probiotic for pregnancy 'ATAU' 'Probiotic AND hypertension AND Prenancy' ATAU Probiotic AND Diabetus mellitus" ATAU ' Probiotic AND Pregnancy AND Review'. Penelusuran ini dilakukan mulai dari Februari hingga Maret 2020 Hasil: Bakteri jenis Lactobacillus dan Bifidobacterium dapat mengobati dan mencegah bakterial vainosis dengan memproduksi zat antibakteri antara lain reutericyclin, asam organik, bakteriosin, reuterin dan hidrogen peroksida. Hidrogen peroksida (H2O2). Bakteri jenis Streptococcus, Escherichia, Lactobacillus, dan Bifidobacterium dapat mensintesis neurotransmiter dalam sistem saraf otonom, mengubah tonus pembuluh darah, mengubah fungsi endotel, dan memproduksi asam lemak / Short Chain Fatty Acid (SCFA) untuk menurunkan tekanan darah. Selain itu Lactobacillus rhamnosus GG dan Bifidobacterium lactis BB12 dilaporkan dapat menurunkan kdar insulin dan risiko GDM Simpulan: Probiotik merupakan mikroba normal yang ada di dalam tubuh, sehingga penambahan dan penggunaannya dalam terapi dapat dipertimbangkan. Belum dilaporkan adanya efek samping berarti dari penggunaan probiotik dalam jangka panjang ataupun pendek, sehingga alternatif terapi probiotik sangat diperhitungkan untuk diberikan pada ibu hamil.

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Contemporary overview of bacterial vaginosis in conventional and complementary and alternative medicine

Sultana

Baig

Rahman

et al. 2022

Computational Intelligence in Healthcare Applications

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The Effectiveness of Adding Probiotic on Antimicrobial for Bacterial Vaginosis: A Systematic Review

Cited by 8 publications

References 15 publications

The Efficacy of Lactobacillus plantarum as Adjunctive Therapy of Bacterial Vaginosis: A Double-blind, Randomized, Placebo-controlled Trial

The Efficacy of Lactobacillus plantarum as Adjunctive Therapy of Bacterial Vaginosis: A Double-blind, Randomized, Placebo-controlled Trial

Probiotik Untuk Kehamilan : A Review

Contemporary overview of bacterial vaginosis in conventional and complementary and alternative medicine

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