The effectiveness of various rabies spatial vaccination patterns in a simulated host population with clumped distribution

Bohrer, Gil; Shem-Tov, Shachar; Summer, Eric; Or, Keren; Saltz, David

doi:10.1016/s0304-3800(02)00003-0

Cited by 10 publications

(7 citation statements)

References 17 publications

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“…Thus, the outcome of our perfectly planned management is largely, not predictable. This insight fits into the recent discussion of spatio-temporal heterogeneity on various scales which can dramatically deform the assumed straight forward link between management plan and its result [39,40]. …”

Section: Discussionsupporting

confidence: 61%

Assessing anti-rabies baiting – what happens on the ground?

Thulke

Selhorst²,

Müller³

et al. 2004

BMC Infect Dis

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Background: Rabies is one of the most hazardous zoonoses in the world. Oral mass vaccination has developed into the most effective management method to control fox rabies. The future need to control the disease in large countries (i.e. Eastern Europe and the Americas) forces cost-benefit discussions. The 'Increase bait density' option refers to the usual management assumption that more baits per km 2 could compensate for high fox abundance and override the imperfect supply of bait pieces to the individual fox.

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Section: Discussionsupporting

confidence: 61%

Assessing anti-rabies baiting – what happens on the ground?

Thulke

Selhorst²,

Müller³

et al. 2004

BMC Infect Dis

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“…1). By revising the current management benchmark, it would be possible to attain a realistic level of rabies control over a greater area (Selhorst, Thulke & Müller 2001; Bohrer et al . 2002).…”

Section: Discussionmentioning

confidence: 99%

Spatial pattern formation facilitates eradication of infectious diseases

Eisinger

Thulke

2008

Journal of Applied Ecology

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Summary 1.Control of animal-born diseases is a major challenge faced by applied ecologists and public health managers. To improve cost-effectiveness, the effort required to control such pathogens needs to be predicted as accurately as possible. In this context, we reviewed the anti-rabies vaccination schemes applied around the world during the past 25 years. 2. We contrasted predictions from classic approaches based on theoretical population ecology (which governs rabies control to date) with a newly developed individual-based model. Our spatially explicit approach allowed for the reproduction of pattern formation emerging from a pathogen's spread through its host population. 3. We suggest that a much lower management effort could eliminate the disease than that currently in operation. This is supported by empirical evidence from historic field data. Adapting control measures to the new prediction would save one-third of resources in future control programmes. 4. The reason for the lower prediction is the spatial structure formed by spreading infections in spatially arranged host populations. It is not the result of technical differences between models. 5. Synthesis and applications. For diseases predominantly transmitted by neighbourhood interaction, our findings suggest that the emergence of spatial structures facilitates eradication. This may have substantial implications for the cost-effectiveness of existing disease management schemes, and suggests that when planning management strategies consideration must be given to methods that reflect the spatial nature of the pathogen-host system.

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“…In some cases, spatial disease models have demonstrated that strategic application can be just as effective as uniform application of control measures (e.g., Haydon et al., ; Shaman, ). For example, non‐uniform application of oral rabies vaccine has been explored by several spatial models and found to be a potentially effective way to reduce the 70% threshold standard that is commonly used for vaccination programs (Bohrer, Shem‐Tov, Summer, Or, & Saltz, ; Eisinger, Thulke, Selhorst, & Müller, ; Russell, Real, & Smith, ; Thulke & Eisinger, ). These are important insights because targeted control measures could increase the benefit–cost ratio of management strategies (Eisinger & Thulke, ).…”

Section: Questions That Spatial Models Have Been Used To Answermentioning

confidence: 99%

Dynamic, spatial models of parasite transmission in wildlife: Their structure, applications and remaining challenges

White

Forester

Craft

2017

Journal of Animal Ecology

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Individual differences in contact rate can arise from host, group and landscape heterogeneity and can result in different patterns of spatial spread for diseases in wildlife populations with concomitant implications for disease control in wildlife of conservation concern, livestock and humans. While dynamic disease models can provide a better understanding of the drivers of spatial spread, the effects of landscape heterogeneity have only been modelled in a few well-studied wildlife systems such as rabies and bovine tuberculosis. Such spatial models tend to be either purely theoretical with intrinsic limiting assumptions or individual-based models that are often highly species- and system-specific, limiting the breadth of their utility. Our goal was to review studies that have utilized dynamic, spatial models to answer questions about pathogen transmission in wildlife and identify key gaps in the literature. We begin by providing an overview of the main types of dynamic, spatial models (e.g., metapopulation, network, lattice, cellular automata, individual-based and continuous-space) and their relation to each other. We investigate different types of ecological questions that these models have been used to explore: pathogen invasion dynamics and range expansion, spatial heterogeneity and pathogen persistence, the implications of management and intervention strategies and the role of evolution in host-pathogen dynamics. We reviewed 168 studies that consider pathogen transmission in free-ranging wildlife and classify them by the model type employed, the focal host-pathogen system, and their overall research themes and motivation. We observed a significant focus on mammalian hosts, a few well-studied or purely theoretical pathogen systems, and a lack of studies occurring at the wildlife-public health or wildlife-livestock interfaces. Finally, we discuss challenges and future directions in the context of unprecedented human-mediated environmental change. Spatial models may provide new insights into understanding, for example, how global warming and habitat disturbance contribute to disease maintenance and emergence. Moving forward, better integration of dynamic, spatial disease models with approaches from movement ecology, landscape genetics/genomics and ecoimmunology may provide new avenues for investigation and aid in the control of zoonotic and emerging infectious diseases.

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The effectiveness of various rabies spatial vaccination patterns in a simulated host population with clumped distribution

Cited by 10 publications

References 17 publications

Assessing anti-rabies baiting – what happens on the ground?

Assessing anti-rabies baiting – what happens on the ground?

Spatial pattern formation facilitates eradication of infectious diseases

Dynamic, spatial models of parasite transmission in wildlife: Their structure, applications and remaining challenges

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