The effects of duration of CO2 insufflation and irrigation on peritoneal microcirculation assessed by free radical scavengers and total glutathion levels during operative laparoscopy

Taşkın, Ömür; Buhur, Ali; Birincioğlu, Mustafa; Burak, Feza; Atmaca, Ruşen; Yılmaz, İsmet; Wheeler, James M.

doi:10.1016/s1074-3804(98)80078-9

Cited by 58 publications

(29 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although the increased level of nitric oxide (implicated in the microvascular dysfunction associated with reperfusion) and malondialdehyde (the end product of lipid peroxidation) stands for an increased splanchnic production of free radicals after laparoscopy [97], many studies assessing different markers of oxidative stress including thiobarbituric acid-reactive substances, plasma total antioxidant status, uric acid, superoxide dismutase, catalase, reduced and oxidized glutathione, and glutathione peroxidase, found significantly less global oxidative stress than in open surgery [106]. Obviously, the influence of reperfusion related mechanisms after laparoscopy and the production of free radicals are smaller than the role of total surgical injury during open surgery [107, 108, 109].…”

Section: Splanchnic Ischemiamentioning

confidence: 99%

Circulatory and Respiratory Complications of Carbon Dioxide Insufflation

Gutt¹,

Oniu

Mehrabi³

et al. 2004

Dig Surg

308

272

View full text Add to dashboard Cite

Background: Although providing excellent outcome results, laparoscopy also induces particular pathophysiological changes in response to pneumoperitoneum. Knowledge of the pathophysiology of a CO₂ pneumoperitoneum can help minimize complications while profiting from the benefits of laparoscopic surgery without concerns about its safety. Methods: A review of articles on the pathophysiological changes and complications of carbon dioxide pneumoperitoneum as well as prevention and treatment of these complications was performed using the Medline database. Results: The main pathophysiological changes during CO₂ pneumoperitoneum refer to the cardiovascular system and are mainly correlated with the amount of intra-abdominal pressure in combination with the patient’s position on the operating table. These changes are well tolerated even in older and more debilitated patients, and except for a slight increase in the incidence of cardiac arrhythmias, no other significant cardiovascular complications occur. Although there are important pulmonary pathophysiological changes, hypercarbia, hypoxemia and barotraumas, they would develop rarely since effective ventilation monitoring and techniques are applied. The alteration in splanchnic perfusion is proportional with the increase in intra-abdominal pressure and duration of pneumoperitoneum. Conclusion: A moderate-to-low intra-abdominal pressure (<12 mm Hg) can help limit the extent of the pathophysiological changes since consecutive organ dysfunctions are minimal, transient and do not influence the outcome.

show abstract

Section: Splanchnic Ischemiamentioning

confidence: 99%

Circulatory and Respiratory Complications of Carbon Dioxide Insufflation

Gutt¹,

Oniu

Mehrabi³

et al. 2004

Dig Surg

308

272

View full text Add to dashboard Cite

show abstract

“…Moreover, it changes blood microcirculation in splanchnic organs (18), as well as the circulation of larger vessels of the abdominal cavity (3). Carbon dioxide-pneumoperitoneum parameters are correlated negatively with free radical scavengers and total glutathione levels (19) and in a graded fashion with an increased level of free radical marker 8-isoprostaglandin F 2a , as well as with lipid peroxidation in the peritoneal tissue (20,21).…”

mentioning

confidence: 99%

Effects of adding small amounts of oxygen to a carbon dioxide–pneumoperitoneum of increasing pressure in rabbit ventilation models

Mynbaev

Adamyan

Mailova

et al. 2009

Fertility and Sterility

View full text Add to dashboard Cite

“…Our experiment has focused on the direct eect of the surgical ambience on cell proliferation. It demonstrates that CO 2 pneumoperitoneum, despite the creation of a very particular ambience with a decreased temperature, microcirculation alterations, and peritoneal acidosis [23], had no impact on tumor growth. Results of MIB1 immunostaining were similar with those of tumor weight.…”

Section: Discussionmentioning

confidence: 95%