The effects of iron deficiency anemia on the thyroid functions

Gökdeniz, Erdem; Demir, Cengiz; Dılek, İmdat

doi:10.5799/ahinjs.01.2010.03.0033

Cited by 11 publications

(7 citation statements)

References 22 publications

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“…8 The hemoglobin levels in the study by erdem found to be 13.3±1.3 while present study revealed 10.12±2.17 in Indian population. The mean age of the patients between 20-40 years is 29.82±7.26 while the mean age for the age for patients 41-65 years is 50.48±6.93.…”

Section: Discussioncontrasting

confidence: 43%

“…7 As of late studies completed in human and creatures have recommended that iron lack can influence the thyroid hormone in digestion system and peroxidase chemical which is catalyzed starting strides of thyroid hormone combination is subjected to the iron. 8 Microcytic anemia for the most part credit to malabsorption of Iron and loss of Iron by menorrhagia, though, macrocytic frailty causes or prompts malabsorption of vitamin B12, folate, pernicious paleness and deficient nourishment. 9 Immune system resulting in hypothyroidism might be connected with signs or side effects of other immune system sicknesses, especially vitiligo, malevolent sickliness, Addison's infection, alopecia areata, also, sort 1 diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

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A prospective study on prevalence and characteristics of hematologic effects associated with subclinical hypothyroidism

Khan

Mohiuddin

2016

Int J Res Med Sci

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INTRODUCTIONDistinctive types of iron deficiency have been accounted for patients with obvious hypothyroidism with a predominance of up to 47%.1 Regardless of the fact that vitamin B12, folic corrosive and iron fixations are ordinary, weakness that standardizes in light of thyroxine substitution is found in up to 25% of hypothyroid patients. 1A weakened erythropoietin (Epo) generation prompts normochromic normocytic sickliness, the most widely recognized type of frailty in thyroid failure. Less continuous types of sickliness in hypothyroidism are hypochromic microcytic pallor connected with iron inadequacy in subclinical hypothyroidism (SCH) is characterized by the finding of lifted TSH levels in the nearness of ordinary circling thyroid hormones.It is not clear whether SCH influences the hematopoietic framework at all and specifically the centralization of hemoglobin and the dissemination of fringe blood components. In this manner, the point of our study was to research the impact of L-thyroxine treatment on fringe blood components in patients with affirmed SCH breaking down information from a planned two fold ABSTRACT Background: Distinctive types of iron deficiency have been accounted for patients with obvious hypothyroidism with a predominance of up to 47%. Regardless of the fact that vitamin B12, folic corrosive and iron fixations are ordinary, weakness that standardizes in light of thyroxine substitution is found in up to 25% of hypothyroid patients. Methods: Briefly, 50 women with SCH were enrolled in the study. Patients between 18 and 65 years old, with TSH levels more than 5.0 mIU/L, the patients selected has a history of hypothyroidism for more than a year and were on oral levothyroxine. A total of 50 participants were enrolled in the study. Blood samples were collected from 50 selected hypothyroid patients on the basis of a history of a hypothyroidism, persistent Anemia, of these patients all were females. Results: In present study 25 cases of age group 41-65 years there were almost 10 patients having high thyroid stimulating factor (Tsh) that is more than (0.3-5.0U/Ml), Constitute to be 40% cases in this age category. Hence patients with high age may slower the response towards a levothyroxine hormone and hence have the high risk of developing anemia. Conclusions: Thyroid dysfunctions have an immediate impact on hemoglobin levels and these progressions should be considered in therapeutic consideration by medical practitioner.

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Section: Discussioncontrasting

confidence: 43%

Section: Introductionmentioning

confidence: 99%

A prospective study on prevalence and characteristics of hematologic effects associated with subclinical hypothyroidism

Khan

Mohiuddin

2016

Int J Res Med Sci

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“…Severe Iron deficiency may lower thyroid peroxidase activity and interfere with the synthesis of thyroid hormones [53,54]. The same results were illustrated by Gökdeniz et al (2010) [55] who reported that hormonal changes returned to normal values with Iron supplementation. Also, Soliman et al (2010) [56] found that total T3 (tT3) and total T4 (tT4) levels of anemic rats were significantly lower than normal control and tT3/tT4 ratio was significantly higher in group treated with (40 mg ferrous sulphate /kg diet) than normal control group.…”

Section: Resultsmentioning

confidence: 86%

“…Secondary and subclinical hypothyroidism were found in Iron deficiency anemia. Hormonal changes returned to normal values with Iron supplementation [55].…”

Section: Resultsmentioning

confidence: 90%

Effect of Iron, Zinc, Vitamin E and Vitamin C Supplementation on Thyroid Hormones in Rats with Hypothyroidism

Rabeh¹,

El-Ghandour²

2016

IJNFS

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Abstract:The aim of the study was to investigate the effect of Iron, Zinc, Vitamin C (Vit.C) and Vitamin E (Vit.E) supplementation on thyroid hormones in rats with hypothyroidism. Thirty six rats were divided into two main groups, the first main group (6 rats) was fed on basal diet only. The second main group (30 rat) were injected with 10 mg/kg/day Propylthiouracil (PTU) to induce hypothyroidism, was divided into 5 subgroups: including control positive group that fed on basal diet, and the other subgroups were fed on basal diet supplemented with 40 mg ferric sulphate/kg diet, 200 mg zinc carbonate /kg diet, 250 mg α-tocohperol acetate/kg/B.W. and 250 mg ascorbic acid/kg/B.W. respectively. Blood samples were collected from each rat and were centrifuged to obtain serum. PTU exposed rats showed hypothyroidism with significant (P<0.05) decline in serum FT3 and FT4 levels together with significant (P<0.05) increase in serum TSH level. The supplementation with Iron, Zinc, Vit.E or Vit.C significantly (P<0.05) increased the level of thyroid hormones (FT4 and FT3) and glutathione peroxidase, moreover, the level of TSH was significantly (P<0.05) decreased, compared with control positive group, might be due to their antioxidant properties. Significant improvement in lipid profile as well as liver and kidney functions were observed. It could be suggested that Vitamin C, Vitamin E, Zinc and Iron could be used as a suitable supplementation therapy for hypothyroidism patients.

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“…Iron deficiency negatively affects the immune system 16 , thyroid metabolism 17 and cognitive functions 18 . On the other hand, iron surplus is related to various pathological conditions such as cancer 19 , neurodegenerative diseases 20 , and damage of liver 21 and testicles 22 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the mobile phone electromagnetic radiation on serum iron parameters in rats

et al. 2017

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Background: Electromagnetic fields (EMF) created by mobile phones during communication have harmful effects on different organs. Objectives: It was aimed to investigate the effects of an EMF created by a mobile phone on serum iron level, ferritin, unsaturated iron binding capacity and total iron binding capacity within a rat experiment model. Methods: A total of 32 male Wistar albino rats were randomly divided into the control, sham, mobile phone speech (2h/day) and stand by (12 h/day) groups. The speech and stand by groups were subjected to the EMF for a total of 10 weeks. Results: No statistically significant difference was observed between the serum iron and ferritin values of the rats in the speech and stand by groups than the control and sham groups (p>0.05). The unsaturated iron binding capacity and total iron capacity values of the rats in the speech and stand by groups were significantly lower in comparison to the control group (p<0.01). Conclusion: It was found that exposure to EMF created by mobile phones affected unsaturated iron binding capacity and total iron binding capacity negatively.

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The effects of iron deficiency anemia on the thyroid functions

Cited by 11 publications

References 22 publications

A prospective study on prevalence and characteristics of hematologic effects associated with subclinical hypothyroidism

A prospective study on prevalence and characteristics of hematologic effects associated with subclinical hypothyroidism

Effect of Iron, Zinc, Vitamin E and Vitamin C Supplementation on Thyroid Hormones in Rats with Hypothyroidism

Evaluation of the mobile phone electromagnetic radiation on serum iron parameters in rats

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