The Effects of Very-Low-Calorie Diets on HDL: A Review

Rolland, Catherine; Broom, John

doi:10.1155/2011/306278

Cited by 15 publications

(11 citation statements)

References 39 publications

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“…The decrease in glucose, total cholesterol, and LDL‐C is similar to what has been found in other weight loss studies . HDL‐C did not show an improvement in this study, which is similar to what has been found in a previous review of weight loss trials .…”

Section: Discussionsupporting

confidence: 91%

A Pilot Internet‐Based Behavioral Weight Loss Intervention with or without Commercially Available Portion‐Controlled Foods

Webber

Rose

2013

Obesity

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Section: Discussionsupporting

confidence: 91%

A Pilot Internet‐Based Behavioral Weight Loss Intervention with or without Commercially Available Portion‐Controlled Foods

Webber

Rose

2013

Obesity

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“…However, FMD can be defined as a very low-calorie diet (VLCD), as the caloric intake is ~800 kCal [ 43 ] for 4 subsequent days. Although previously reported studies applying VLCD are very heterogeneous, there is some evidence that adherence to VLCD can result in a decrease in HDL levels; however, after the completion of VLCD, HDL levels tend to regain previous levels or even surpass them [ 44 ], which was also evident in the pilot data of our study (data not shown). Therefore, based on the cyclic and short-term regimen of FMD, we believe it should not be considered detrimental in terms of the reduction in HDL levels and development of atherosclerosis.…”

Section: Discussionsupporting

confidence: 75%

Fasting-Mimicking Diet Reduces Trimethylamine N-Oxide Levels and Improves Serum Biochemical Parameters in Healthy Volunteers

et al. 2022

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Elevated plasma levels of trimethylamine N-oxide (TMAO) have been proposed as a diet-derived biomarker of cardiometabolic disease risk. Caloric restriction is the most common dietary intervention used to improve cardiometabolic health; however, novel trends suggest a fasting-mimicking diet (FMD) as a more feasible alternative. FMD is a variation of intermittent fasting, based on caloric restriction and limitation of protein sources of animal origin, applied in daily cycles during a 5-day period. As TMAO is intensively produced by gut microbiota after the consumption of animal-derived products, we aim to investigate whether a 5-day FMD affects plasma TMAO levels and markers of metabolic health. To investigate whether an increase in vegetable intake possesses similar effects on TMAO levels and metabolic parameters, healthy volunteers (n = 24) were subjected to a 5-day FMD and 19 volunteers served as a reference group (VEG). This group of volunteers consumed an additional four servings of vegetables per day, but otherwise stayed on their usual diet. FMD resulted in a twofold decrease in plasma TMAO levels, which was not evident in the volunteers from the VEG group. Moreover, FMD led to a weight loss of 2.8 ± 0.2 kg and a subsequent reduction in BMI compared to baseline. The FMD group exhibited a significant elevation in plasma ketone bodies (14-fold compared to baseline) and a decrease in IGF-1 levels by 37 ± 8 ng/mL. Since fasting glucose and C-peptide levels decreased, all volunteers in the FMD group showed improved insulin sensitivity and a decreased HOMA-IR index. In contrast, in the VEG group, only a slight reduction in plasma levels of fasting glucose and triglycerides was noted. In conclusion, we show that FMD is a viable strategy to reduce plasma levels of TMAO by limiting caloric intake and animal-derived protein consumption. The reduction in the level of TMAO could be an additional benefit of FMD, leading to a reduced risk of cardiometabolic diseases.

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“…Obesity, sedentarism and fat‐rich diet intake are determinants of metabolic diseases and their complications (Márquez‐Sandoval et al . ; Rolland & Broom ). Animals nourished with the hyperlipidic diet showed greater weight gain and higher lipid serum levels during the experiment.…”

Section: Discussionmentioning

confidence: 99%

“…Differences found in biomechanics and trabecular area among the experimental groups were due to the hyperlipidic diet and effects of simvastatin administration and not to malnutrition and/or dehydration. Obesity, sedentarism and fat-rich diet intake are determinants of metabolic diseases and their complications (M arquez- Sandoval et al 2011;Rolland & Broom 2011). Animals nourished with the hyperlipidic diet showed greater weight gain and higher lipid serum levels during the experiment.…”

Section: Discussionmentioning

confidence: 99%

Metabolic and structural bone disturbances induced by hyperlipidic diet in mice treated with simvastatin

Soares

Novaes

Nakagaki

et al. 2015

Int J Experimental Path

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Simvastatin can modulate lipid and bone metabolism. However, information related to the interaction between diet and simvastatin on bone structure and biomechanics is scarce. Thus, this study evaluated the effects of simvastatin on femoral biomechanics and cortical/trabecular bone structure in wild-type mice nourished with a hyperlipidic diet. Three-month-old male wild-type mice (C57BL6 strain) were divided into four groups: (1) group W, nourished with a standard diet; (2) group WH, fed a hyperlipidic diet; (3) group WS, nourished with a standard diet plus oral simvastatin (20 mg/kg/day); and (4) group WHS, fed a hyperlipidic diet plus oral simvastatin (20 mg/kg/day). All animals received only their specific diet and water for 60 days. Blood samples were collected for the analysis of calcium, triglycerides, total cholesterol (TC) and fraction serum levels. Diet manipulation was able to induce a dyslipidaemic status in mice, characterized by triglyceride and TC rise in WH animals. Simvastatin prevented hypercholesterolaemia and reduced TC and LDL serum levels, but did not prevent hypertriglyceridaemia and HDL serum levels in the WHS group. In the WH mice the hyperlipidaemia was associated with reduction in trabecular bone thickness, femur structural and material property alterations. Simvastatin prevented these morphological alterations and minimized femur biomechanical changes in WHS mice. Taken together, the results indicated that the hyperlipidic diet intake acts as a risk factor for bone integrity, generating bones with reduced resistance and more susceptible to fractures, an effect attenuated by simvastatin that is potentially related to the modulatory action of this drug on lipid and bone metabolism.

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The Effects of Very-Low-Calorie Diets on HDL: A Review

Cited by 15 publications

References 39 publications

A Pilot Internet‐Based Behavioral Weight Loss Intervention with or without Commercially Available Portion‐Controlled Foods

A Pilot Internet‐Based Behavioral Weight Loss Intervention with or without Commercially Available Portion‐Controlled Foods

Fasting-Mimicking Diet Reduces Trimethylamine N-Oxide Levels and Improves Serum Biochemical Parameters in Healthy Volunteers

Metabolic and structural bone disturbances induced by hyperlipidic diet in mice treated with simvastatin

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