The Efficacy of Bifidobacterium longum BORI and Lactobacillus acidophilus AD031 Probiotic Treatment in Infants with Rotavirus Infection

Abstract

A total of 57 infants hospitalized with rotavirus disease were included in this study. The children were randomly divided into the study’s two treatment groups: three days of the oral administration of (i) a probiotics formula containing both Bifidobacterium longum BORI and Lactobacillus acidophilus AD031 (N = 28); or (ii) a placebo (probiotic-free skim milk, N = 29) and the standard therapy for diarrhea. There were no differences in age, sex, or blood characteristics between the two groups. When the 57 cases completed the protocol, the duration of the patients’ diarrhea was significantly shorter in the probiotics group (4.38 ± 1.29, N = 28) than the placebo group (5.61 ± 1.23, N = 29), with a p-value of 0.001. Symptoms such as duration of fever (p = 0.119), frequency of diarrhea (p = 0.119), and frequency of vomiting (p = 0.331) tended to be ameliorated by the probiotic treatment; however, differences were not statistically significant between the two groups. There were no serious, adverse events and no differences in the frequency of adverse events in both groups.

Beneficial Effects of Probiotic Consumption on the Immune System

“…Namely, protection against infections [5][6][7], relief of irritable bowel symptoms [8], inhibition of Helicobacter pylori growth [9], prevention of cancer [10][11][12], decrease in gut inflammatory response [13], and prevention of allergies [14,15]. In humans, although probiotics have shown encouraging results in several health conditions like diabetes, multi-drug resistant pathogens, irritable bowel syndrome [16][17][18], exhaustive research is still required to incorporate probiotics into human health, nutrition, and regulation of different abnormalities.…”

Anti-Obesity Effects of a Mixture of Fermented Ginseng, Bifidobacterium longum BORI, and Lactobacillus paracasei CH88 in High-Fat Diet-Fed Mice

“…Bifidobacterium longum BORI and Lactobacillus paracasei CH88 were industrially developed and various health benefits have been reported. B. longum BORI has novel probiotic features, and the frequency of diarrhea was significantly reduced in rotavirus-infected children with acute colitis [4]. B. longum BORI demonstrated the highest anti-obesity effect on weight loss as well as inhibited lipid deposition in the liver of HFD-fed mice [5].…”

New Progress regarding the Use of Lactic Acid Bacteria as Live Delivery Vectors, Treatment of Diseases and Induction of Immune Responses in Different Host Species Focusing on <i>Lactobacillus</i> Species

“…The study about the use of fermented dairy drink containing probiotic Lactobacillus paracasei CNCM I-1518 to prevent Antibiotic-associated diarrhea showed the importance of Lactobacillus strains in improving health [58]. Also older hospitalized patients treated with antibiotics lead to considerable cost savings, in addition to Infants hospitalized with rotavirus disease were treated with probiotics containing both Bifidobacterium longum BORI and Lactobacillus acidophilus AD031, Symptoms such as duration of fever, frequency of diarrhea, and frequency of vomiting tended to be ameliorated by the probiotic treatment [59].…”