The efficacy of Nigella Sativa L extracts to reduce cardiovascular disease risk in diabetic dyslipidemia

Abstract

Diabetic diseases often witnessing complication with dyslipidemia that also easily experiencing status of oxidative stress. This study aimed to determine the potential of Nigella sativa L. seed extract in reducing lipoprotein serum and liver oxidative stress in diabetic dyslipidemia. Diabetic dyslipidemia rats were carried out by giving a high feed diet (HFD) for 14 weeks and injecting streptozotocin (STZ) at dose 30 mg/kgbw intraperitoneally once a week at the beginning of 9th and 10th week. The treatments of Nigella sativa L. seed extracts were given between 11th -14th week. The ANOVA test showed that the Nigella sativa L. extract and metformin had a significant effect on LDL, HDL, and SOD levels. In addition, the DMRT test indicated that administration of the extract at the dose of 24-48 mg/kgbw was the most effective treatment in reducing LDL level, as well as in increasing HDL and SOD levels. The Kruskal Wallis test showed that the administration of Nigella sativa L. extract has effected on MDA level; furthermore, Mann Whitney test revealed that giving the extract at all doses were effective in reducing MDA. This effect met the standard of metformin drug until the animals got healthy again. It can be concluded that the antioxidant and hypolipidemic effects of Nigella sativa L. extract are potential in reducing the risk of cardiovascular disease in patients with diabetic hyperlipidemia.

Fight against Covid-19: Nigella sativa, a Potential Curative

“…Another research done on the effect of N. Sativa over lipid profiles of post-menopausal women showed immense improvements with decreased total cholesterol, low-density lipoprotein cholesterol, triglyceride, and increased high-density lipoprotein cholesterol [89]. In rats with diabetic dyslipidemia, administration of N. Sativa seed extracts showed a reduction in LDL level, as well as an increase in HDL and SOD levels hence reducing the risk of cardiovascular disease [90]. Thymoquinone, a component of N. Sativa, is shown to recover endothelial function at least in part, via inhibition of oxidative stress and regulation of the renin-angiotensin system [91].…”

The Potential of Black Cumin (Nigella sativa, L.) Seeds Extract to Prevent Polyphagia and Weight Loss in Rattus Norvegicus of Diabetes Mellitus-Type 2

“…Consumption of black cumin seeds customarily has been reported to the public and laboratory tests related to N. sativa as an antioxidant, antibacterial, anti-fungal, anticancer, anti-inflammatory, antiallergic, hepatoprotector [11], antifertility [12]. The ethanol extract of N. sativa seeds can decrease blood glucose levels and able to improve the lipid profile of serum DM-2 rats [13]. Thymoquinone is the main active compound in N. sativa as an antidiabetic, one of which is through its potential to reduce liver gluconeogenesis [14].…”