The existence of cognitive plateaus in Alzheimer's disease

Bozoki, Andrea; An, Hyonggin; Bozoki, E.; Little, Roderick J. A.

doi:10.1016/j.jalz.2009.05.669

Cited by 16 publications

(9 citation statements)

References 24 publications

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“…The relative cerebral blood flow (relCBF) is reduced notably in the posterior cingulate cortex (PCC), which overlaps with the patterns of hypometabolism on 18F-2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) in clinically overt and incipient AD cases [116][117][118][119]. The correspondence between ASL and PET findings is consistent with the known perfusion-metabolism coupling in the brain [120].…”

Section: Principlessupporting

confidence: 61%

State-of-the-art MRI techniques in neuroradiology: principles, pitfalls, and clinical applications

et al. 2015

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This article reviews the most relevant state-of-the-art magnetic resonance (MR) techniques, which are clinically available to investigate brain diseases. MR acquisition techniques addressed include notably diffusion imaging (diffusion-weighted imaging (DWI), diffusion tensor imaging (DTI), and diffusion kurtosis imaging (DKI)) as well as perfusion imaging (dynamic susceptibility contrast (DSC), arterial spin labeling (ASL), and dynamic contrast enhanced (DCE)). The underlying models used to process these images are described, as well as the theoretic underpinnings of quantitative diffusion and perfusion MR imaging-based methods. The technical requirements and how they may help to understand, classify, or follow-up neurological pathologies are briefly summarized. Techniques, principles, advantages but also intrinsic limitations, typical artifacts, and alternative solutions developed to overcome them are discussed. In this article, we also review routinely available three-dimensional (3D) techniques in neuro MRI, including state-of-the-art and emerging angiography sequences, and briefly introduce more recently proposed 3D quantitative neuro-anatomy sequences, and new technology, such as multi-slice and multi-transmit imaging.

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Section: Principlessupporting

confidence: 61%

State-of-the-art MRI techniques in neuroradiology: principles, pitfalls, and clinical applications

et al. 2015

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“…Disease progression is characterized by high between-subject variability. Moreover, so-called ‘plateaus’ are reached during which cognitive performance remains relatively stable [171]. Number and duration of those plateaus are also subject to high variance.…”

Section: Neurocognitive Changes Associated With Alzheimer’s Diseasementioning

confidence: 99%

Dissociating Normal Aging from Alzheimer’s Disease: A View from Cognitive Neuroscience

Toepper

2017

JAD

140

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Both normal aging and Alzheimer’s disease (AD) are associated with changes in cognition, grey and white matter volume, white matter integrity, neural activation, functional connectivity, and neurotransmission. Obviously, all of these changes are more pronounced in AD and proceed faster providing the basis for an AD diagnosis. Since these differences are quantitative, however, it was hypothesized that AD might simply reflect an accelerated aging process. The present article highlights the different neurocognitive changes associated with normal aging and AD and shows that, next to quantitative differences, there are multiple qualitative differences as well. These differences comprise different neurocognitive dissociations as different cognitive deficit profiles, different weights of grey and white matter atrophy, and different gradients of structural decline. These qualitative differences clearly indicate that AD cannot be simply described as accelerated aging process but on the contrary represents a solid entity.

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“…Alzheimer's disease (AD) is characterized by progressive cognitive decline, loss of daily functions, and neuropsychiatric symptoms. There is evidence that cognitive deterioration is slower during the early phase of the disease Stern et al, 1994;Feldman et al, 2005) and that change can be non-linear Bozoki et al, 2009). Cortes et al (2005) reported significant declines in cognition, activities of daily living (ADL), and neuropsychiatric symptoms within one year in a population of AD patients (Cortes et al, 2005); however, one-quarter of these AD patients were stable during a two-year follow-up (Cortes et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Progression of Alzheimer's disease during a three-year follow-up using the CERAD-NB total score: Kuopio ALSOVA study

Hallikainen

Hänninen

Fraunberg

et al. 2013

Int. Psychogeriatr.

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The CERAD total score is a suitable and sensitive follow-up tool in longitudinal AD trials. Cognition progression rates did not significantly differ between study groups; however, patients with very mild AD at baseline had milder neuropsychiatric symptoms after long-term follow-up. This emphasizes the importance of early diagnosis and assessment of neuropsychiatric symptoms at the diagnostic visit and during follow-up.

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The existence of cognitive plateaus in Alzheimer's disease

Cited by 16 publications

References 24 publications

State-of-the-art MRI techniques in neuroradiology: principles, pitfalls, and clinical applications

State-of-the-art MRI techniques in neuroradiology: principles, pitfalls, and clinical applications

Dissociating Normal Aging from Alzheimer’s Disease: A View from Cognitive Neuroscience

Progression of Alzheimer's disease during a three-year follow-up using the CERAD-NB total score: Kuopio ALSOVA study

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