2009
DOI: 10.1038/nrg2664
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The genetics of inbreeding depression

Abstract: Inbreeding depression - the reduced survival and fertility of offspring of related individuals - occurs in wild animal and plant populations as well as in humans, indicating that genetic variation in fitness traits exists in natural populations. Inbreeding depression is important in the evolution of outcrossing mating systems and, because intercrossing inbred strains improves yield (heterosis), which is important in crop breeding, the genetic basis of these effects has been debated since the early twentieth ce… Show more

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Cited by 1,703 publications
(1,638 citation statements)
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“…There are two genetically distinct ways in which increased homozygosity can lower fitness: increased homozygosity for partially recessive detrimental mutations and increased homozygosity for alleles at loci with heterozygote advantage ('overdominance'). Deleterious alleles will generally be present in populations at low frequencies (mutation-selection balance), whereas overdominant alleles at a locus are maintained at intermediate frequencies by balancing selection (Charlesworth & Willis 2009). Darwin (1876 and1877) was the first to point out that the evident adaptations of many plants to ensure outcrossing could be understood in terms of the selective advantage of avoiding inbreeding depression.…”
Section: Palavras-chavementioning
confidence: 99%
“…There are two genetically distinct ways in which increased homozygosity can lower fitness: increased homozygosity for partially recessive detrimental mutations and increased homozygosity for alleles at loci with heterozygote advantage ('overdominance'). Deleterious alleles will generally be present in populations at low frequencies (mutation-selection balance), whereas overdominant alleles at a locus are maintained at intermediate frequencies by balancing selection (Charlesworth & Willis 2009). Darwin (1876 and1877) was the first to point out that the evident adaptations of many plants to ensure outcrossing could be understood in terms of the selective advantage of avoiding inbreeding depression.…”
Section: Palavras-chavementioning
confidence: 99%
“…Inbreeding depression is thought to arise primarily from deleterious recessive mutations whose detrimental effects are only revealed once they become homozygous (identical by descent) in inbred individuals (Falconer and Mackay 1996; Lynch and Walsh 1998; Charlesworth and Willis 2009). Traits under directional selection, such as fitness, typically show a decline in performance with decreasing condition (Rowe and Houle 1996).…”
Section: Introductionmentioning
confidence: 99%
“…[1][2][3][4] An effect of consanguineous mating recognizable in most organisms is inbreeding depression, defined as the reduced survival and fertility of offspring of related individuals. 5 A plausible explanation for inbreeding depression is increased homozygosity for partially recessive deleterious mutations (partial dominance). This explanation is currently favored over the alternative of increased homozygosity for alleles at loci with heterozygote advantage (overdominance).…”
Section: Introductionmentioning
confidence: 99%