The global response to the COVID-19 pandemic: how have immunology societies contributed?

Osier, Faith; Ting, Jenny P.Y.; Fraser, John D.; Lambrecht, Bart N.; Romano, Márta; Gazzinelli, Ricardo T.; Bortoluci, Karina Ramalho; Zamboni, Dario S.; Akbar, Arne N.; Evans, Jennie; Brown, Doug E.; Patel, Kamala D.; Wu, Yuzhang; Pérez, Ana B.; Pérez, Óliver; Kamradt, Thomas; Falk, Christine S.; Barda‐Saad, Mira; Ariel, Amiram; Santoni, Angela; Annunziato, Francesco; Cassatella, Marco A.; Kiyono, Hiroshi; Chereshnev, V. А.; Dièye, Alioune; Mbow, Moustapha; Mbengué, Babacar; Niang, Maguette Sylla; Suchard, Melinda

doi:10.1038/s41577-020-00428-4

Cited by 19 publications

(13 citation statements)

References 28 publications

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“…Since the first case of COVID-19 was diagnosed in Wuhan, China, in December 2019, COVID-19 has spread globally becoming a pandemic 17 . The majority of COVID-19-related damage occurs in the pulmonary system, manifesting as typical pulmonary infection symptoms, including cough, shortness of breath, fever, and fatigue 18 . Furthermore, ACE-2 signaling is widely accepted to contribute to the progression of COVID-19, although the specific mechanism remains elusive 19 , 20 .…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2-induced Overexpression of miR-4485 Suppresses Osteogenic Differentiation and Impairs Fracture Healing

Mi¹,

Xiong²,

Zhang³

et al. 2021

Int. J. Biol. Sci.

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The angiotensin-converting enzyme 2 (ACE2) receptor has been identified as the cell entry point for SARS-CoV-2. Although ACE2 receptors are present in the bone marrow, the effects of SARS-CoV-2 on the biological activity of bone tissue have not yet been elucidated. In the present study we sought to investigate the impact of SARS-CoV-2 on osteoblastic activity in the context of fracture healing. MicroRNA-4485 (miR-4485), which we found to be upregulated in COVID-19 patients, negatively regulates osteogenic differentiation. We demonstrate this effect both in vitro and in vivo . Moreover, we identified the toll-like receptor 4 (TLR-4) as the potential target gene of miR-4485, and showed that reduction of TLR-4 induced by miR-4485 suppresses osteoblastic differentiation in vitro . Taken together, our findings highlight that up-regulation of miR-4485 is responsible for the suppression of osteogenic differentiation in COVID-19 patients, and TLR-4 is the potential target through which miR-4485 acts, providing a promising target for pro-fracture-healing and anti-osteoporosis therapy in COVID-19 patients.

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Section: Discussionmentioning

confidence: 99%

SARS-CoV-2-induced Overexpression of miR-4485 Suppresses Osteogenic Differentiation and Impairs Fracture Healing

Mi¹,

Xiong²,

Zhang³

et al. 2021

Int. J. Biol. Sci.

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“…In addition to the above-discussed war rhetoric adopted by various politicians in their response to coronavirus outbreak and the ensuing individualising measures such as social distancing and quarantine, scientists themselves have repetitively invoked the language of defence in their discussions and clinical studies of Covid-19. For instance, a recent article from Nature Reviews Immunology by Osier et al ( 2020 ) brought together various international immunology societies to discuss how their field responded to Covid-19 pandemic. In most responses, immunity was articulated in terms of defence and self-protection as if these were the default vocabulary for referring to immunity.…”

Section: The Defensive Politics Of Immunitymentioning

confidence: 99%

Immunitarianism: defence and sacrifice in the politics of Covid-19

Ajana

2021

HPLS

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As witnessed over the last year, immunity emerged as one of most highly debated topics in the current Covid-19 pandemic. Countries around the globe have been debating whether herd immunity or lockdown is the best response, as the race continues for the development and rollout of effective vaccines against coronavirus and as the economic costs of implementing strict containment measures are weighed against public health costs. What became evident all the more is that immunity is precisely what bridges between biological life and political life in the current climate, be it in terms of the contentious notion of herd immunity, the geopolitical struggle for vaccines, or the possible emergence of “Covid-elite”, i.e. holders of so-called “immunity passports”. Immunity, as such, is certainly not only a matter of science and biology alone, but is inherently political in the way that pandemics themselves are often highly politicised. Drawing on the work of Roberto Esposito and other literature from the field of biopolitics and immunology, this paper provides a critical examination of the concept of immunity in light of the recent events, highlighting the intersections between the politics of defence and the politics of sacrifice which animate governments’ immunitary responses to the Covid-19 pandemic. The paper ends with a discussion on the forms of solidarity and local initiatives that have been mobilised during the current pandemic and their potential for an affirmative form of biopolitics. Overall, the main aim of this paper is to provide a critical cultural and philosophical analysis of Covid-19 debates and responses and a nuanced account on the biopolitical effects of the current pandemic, highlighting the paradoxical nature of immunity which straddles at once negative practices of defence and sacrifice as well as affirmative forms of community and solidarity beyond state apparatuses.

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“…The American Association of Immunologists (AAI), the British Society for Immunology, ‘Immunopedia’, and the International Union of Immunological Societies are a selection of immunology-focused societies, in addition to publishing companies, that set up online COVID-19 resources. A summary of current activities was reported recently: ‘The global response to the COVID-19 pandemic: how have immunology societies contributed?’ [ 4 ]. Major immunology specialty journals, such as Immunity and Trends in Immunology within the Cell Press Coronavirus Resource Hub iv , as well as others, such as Nature Immunology and Science Immunology , are collating relevant COVID-19 literature, making it freely available.…”

Section: How Have Immunologists Contributed To Fighting the Covid-19mentioning

confidence: 99%

“…A summary of current activities was reported recently: 'The global response to the COVID-19 pandemic: how have immunology societies contributed?' [4]. Major immunology specialty journals, such as Immunity and…”

Section: Access To Resources and Knowledgementioning

confidence: 99%

The Immunologists’ Guide to Pandemic Preparedness

Marín‐Hernández

Hupert

Nixon

2021

Trends in Immunology

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Immunologists are central to fighting any pandemic. From pathogenesis to disease modeling, pharmaceuticals to vaccines, immunologists play a crucial role in translating basic science into effective response strategies. This article describes our view on how lessons from the coronavirus disease 2019 (COVID-19) pandemic can be developed into an immunologists’ guide for preparedness for future pandemics.

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The global response to the COVID-19 pandemic: how have immunology societies contributed?

Cited by 19 publications

References 28 publications

SARS-CoV-2-induced Overexpression of miR-4485 Suppresses Osteogenic Differentiation and Impairs Fracture Healing

SARS-CoV-2-induced Overexpression of miR-4485 Suppresses Osteogenic Differentiation and Impairs Fracture Healing

Immunitarianism: defence and sacrifice in the politics of Covid-19

The Immunologists’ Guide to Pandemic Preparedness

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