2011
DOI: 10.1016/j.brainres.2010.09.092
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The impact of agrin on the formation of orthogonal arrays of particles in cultured astrocytes from wild-type and agrin-null mice

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Cited by 31 publications
(35 citation statements)
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“…All these in vivo investigations suggest that the microenvironment in the brain is more important for the formation of OAPs than the M23 / M1 relation (Table 1). Furthermore, in vitro experiments showed that murine astrocyte cultures form more OAPs when growing on agrin-coated surfaces or in agrin-containing culture medium [19,20]. …”
Section: Discussionmentioning
confidence: 99%
“…All these in vivo investigations suggest that the microenvironment in the brain is more important for the formation of OAPs than the M23 / M1 relation (Table 1). Furthermore, in vitro experiments showed that murine astrocyte cultures form more OAPs when growing on agrin-coated surfaces or in agrin-containing culture medium [19,20]. …”
Section: Discussionmentioning
confidence: 99%
“…The above experiments should not be taken to suggest that agrin is the only factor underpinning astrocytic polarization. Indeed, agrin knockout animals display a residual pool of endfoot AQP4, indicating that other factors also contribute (Fallier‐Becker et al, ). It is relevant in this regard that astrocyte processes reaching the top surface of the filter are exposed not only to the soluble factors that the endothelial cells secrete, but also to the mechanical stress they impose.…”
Section: Discussionmentioning
confidence: 99%
“…37 When the BBB is disrupted after an ICH, agrin and orthogonal arrays of particles/AQP-4 are released, resulting in upregulation of AQP-4. 38 Agrin is downregulated in hyperglycemia, 39 thus increased BBB destruction, less AQP-4 production, and more severe cellular breakdown associated with necrosis would be expected as compared with a normoglycemic state. …”
Section: Discussionmentioning
confidence: 99%