The impact of hydration status and fluid distribution on pulmonary function in COPD patients

Orea-Tejeda, Arturo; Gómez-Martínez, Manuel; González-Islas, Dulce; Flores-Cisneros, Laura; Sánchez-Santillán, Rocío; Pérez-García, Ilse; Martínez-Luna, Nathalie; Robles, Robinson E; Sánchez-Moreno, Carlos; Orozco-Gutiérrez, Juan José

doi:10.1038/s41598-022-05192-0

Cited by 4 publications

(7 citation statements)

References 41 publications

(55 reference statements)

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“…In one investigation, pulmonary edema and pleural effusion in individuals with renal illness were linked to fluid overload and pulmonary capillary permeability; this association may explain why patients with end-stage renal disease have diminished lung function. 99 Increased ECW/ICW and lower extremity water are linked to exercise intolerance in COPD patients, and alterations in cellular hydration status may have an impact on how well their skeletal muscles use oxygen. 100 The ECW/ICW ratio is also negatively correlated with peak oxygen consumption in COPD patients.…”

Section: Body Watermentioning

confidence: 99%

“… 100 The ECW/ICW ratio is also negatively correlated with peak oxygen consumption in COPD patients. In COPD patients with sarcopenia, 99 and much more so in those with severe sarcopenia, 101 the ECW/ICW ratio is elevated.…”

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Body Composition and COPD: A New Perspective

Wang¹,

Liang²,

Li³

et al. 2023

COPD

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The proportion of obese or overweight patients in COPD patients is increasing. Although BMI, WC and other easy to measure indicators have been proven to be related to the risk of COPD, they cannot accurately reflect the distribution and changes of body composition, ignoring the body composition (such as fat distribution, muscle content, water content, etc.), the relationship between it and disease risk may be missed. By analyzing the correlation between different body composition indexes and COPD patients, we can provide new research ideas for the prognosis judgment or intervention of COPD disease.

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Section: Body Watermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Body Composition and COPD: A New Perspective

Wang¹,

Liang²,

Li³

et al. 2023

COPD

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“…In addition to muscle status, hydration status is also important in body composition. As muscle loss is often accompanied by water imbalance ( 14 ). The intracellular component of FFM is mostly water, and BIA technology can indirectly and easily measure the water distribution based on the electrical impedance of current conduction in the body ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

Correlation between body composition and disease severity in patients with chronic obstructive pulmonary disease

Jin,

Yang,

Chen

et al. 2024

Front. Med.

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BackgroundBody composition changes are important extrapulmonary manifestations in chronic obstructive pulmonary disease (COPD) patients. This study aimed to investigate the characteristics of body composition in patients with COPD, and its correlation with disease severity.MethodsA total of 105 COPD patients admitted to Zhongshan Hospital affiliated to Dalian University, from May 1, 2021 to January 31, 2023, were included as the COPD group, and 105 subjects without COPD were enrolled as the control group during the same period. According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) comprehensive assessment indicators, COPD patients were divided into groups: the degree of pulmonary function airflow limitation was grouped according to FEV1%pred; clinical symptoms were grouped according to mMRC scores and CAT scores; the risk of acute exacerbation was divided into low risk and high risk groups. Body composition was measured by bioelectrical impedance analysis (BIA).Results(1) Concerning body composition, the body mass index (BMI), fat-free mass index (FFMI), and angle of phase (PhA) of COPD patients were lower than those of the control group. Extracellular water-to-total body water ratio (ECW/TBW) and extra-to-intracellular water ratio (ECW/ICW) were higher than those of the control group, and the difference was statistically significant (p < 0.05). (2) There were differences in body composition among COPD patients with different severity of disease: FFMI and PhA in the mild/moderate airflow limitation group were higher than those in the severe/very severe airflow limitation group. According to mMRC scores classification, the FFMI and PhA of the less symptomatic group were higher than those of the more symptomatic group, and ECW/TBW and ECW/ICW were lower than those of the more symptomatic group. According to CAT scores classification, FFMI and PhA in the mild/moderate disease group were higher than those in the severe/very severe disease group. The FFMI of the low-risk group was higher than that of the high-risk group, and ECW/TBW was lower than that of the high risk group. (3) Correlation analysis between body composition and disease severity indicators showed that FFMI and PhA were negatively correlated with mMRC scores and CAT scores, and positively correlated with FEV1%pred. ECW/TBW ratio and ECW/ICW ratio were positively correlated with mMRC scores and CAT scores, and negatively correlated with FEV1%pred, and the difference was statistically significant (p < 0.05).ConclusionThere are significant differences in body composition between COPD patients and the control group, and there are significant differences in body composition between COPD patients with different severity of disease, with correlations between body composition and severity of disease.

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“…COPD is considered a global public health problem because it is the third leading cause of death [ 2 ]. Patients with COPD have characteristics such as low cell integrity, body cell mass, disturbances in water distribution between intracellular and extracellular compartments as evidenced by low phase angle (PhA) and higher impedance ratio (IR), as well as low muscle strength, low muscle mass, and sarcopenia [ 3 , 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Body Composition and Sarcopenia on Mortality in Chronic Obstructive Pulmonary Disease Patients

Gómez-Martínez

Rodríguez-García

González-Islas

et al. 2023

JCM

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Background: Patients with chronic obstructive pulmonary disease (COPD) have alterations in body composition, such as low cell integrity, body cell mass, and disturbances in water distribution evidenced by higher impedance ratio (IR), low phase angle (PhA), as well as low strength, low muscle mass, and sarcopenia. Body composition alterations are associated with adverse outcomes. However, according to the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), the impact of these alterations on mortality in COPD patients is not well-established. Our aims were to evaluate whether low strength, low muscle mass, and sarcopenia impacted mortality in COPD patients. Methods: A prospective cohort study performance was conducted with COPD patients. Patients with cancer, and asthma were excluded. Body composition was assessed by bioelectrical impedance analysis. Low strength and muscle mass, and sarcopenia were defined according to EWGSOP2. Results: 240 patients were evaluated, of whom 32% had sarcopenia. The mean age was 72.32 ± 8.24 years. The factors associated with lower risk of mortality were handgrip strength (HR:0.91, CI 95%; 0.85 to 0.96, p = 0.002), PhA (HR:0.59, CI 95%; 0.37 to 0.94, p = 0.026) and exercise tolerance (HR:0.99, CI 95%; 0.992 to 0.999, p = 0.021), while PhA below the 50th percentile (HR:3.47, CI 95%; 1.45 to 8.29, p = 0.005), low muscle strength (HR:3.49, CI 95%; 1.41 to 8.64, p = 0.007) and sarcopenia (HR:2.10, CI 95%; 1.02 to 4.33, p = 0.022) were associated with a higher risk of mortality. Conclusion: Low PhA, low muscle strength, and sarcopenia are independently associated with poor prognosis in COPD patients.

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The impact of hydration status and fluid distribution on pulmonary function in COPD patients

Cited by 4 publications

References 41 publications

Body Composition and COPD: A New Perspective

Body Composition and COPD: A New Perspective

Correlation between body composition and disease severity in patients with chronic obstructive pulmonary disease

Impact of Body Composition and Sarcopenia on Mortality in Chronic Obstructive Pulmonary Disease Patients

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