The impact of winter epidemics of influenza and respiratory syncytial virus on paediatric admissions to an urban general hospital

Sugaya, Norio; Mitamura, Keiko; Nirasawa, Mari; Takahashi, Koji

doi:10.1002/(sici)1096-9071(200001)60:1<102::aid-jmv17>3.0.co;2-d

Cited by 46 publications

(21 citation statements)

References 17 publications

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“…Most studies enrolled patients year-round for one or more years, with the exception of two Japanese studies where enrollment was limited to winter months. 12,13 All studies collected nasopharyngeal specimens, either aspirates or swabs, from acutely ill participants. Fourteen studies utilized cell culture as their primary influenza diagnostic approach.…”

Section: Resultsmentioning

confidence: 99%

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The burden of influenza in East and South‐East Asia: a review of the English language literature

Simmerman

Uyeki

2008

Influenza Resp Viruses

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While human infections with avian influenza A (H5NI) viruses in Asia have prompted concerns about an influenza pandemic, the burden of human influenza in East and Southeast Asia has received far less attention. We conducted a review of English language articles on influenza in 18 countries in East and Southeast Asia published from 1980 to 2006 that were indexed on PubMed. Articles that described human influenza‐associated illnesses among outpatients or hospitalized patients, influenza‐associated deaths, or influenza‐associated socioeconomic costs were reviewed. We found 35 articles from 9 countries that met criteria for inclusion in the review. The quality of articles varied substantially. Significant heterogeneity was noted in case definitions, sampling schemes and laboratory methods. Early studies relied on cell culture, had difficulties with specimen collection and handling, and reported a low burden of disease. The recent addition of PCR testing has greatly improved the proportion of respiratory illnesses diagnosed with influenza. These more recent studies reported that 11–26% of outpatient febrile illness and 6‐14% of hospitalized pneumonia cases had laboratory‐confirmed influenza infection. The influenza disease burden literature from East and Southeast Asia is limited but expanding. Recent studies using improved laboratory testing methods and indirect statistical approaches report a substantial burden of disease, similar to that of Europe and North America. Current increased international focus on influenza, coupled with unprecedented funding for surveillance and research, provide a unique opportunity to more comprehensively describe the burden of human influenza in the region.

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Section: Resultsmentioning

confidence: 99%

“…However, several studies from middle and high income countries (Thailand, Hong Kong, Singapore, Japan) reported that the estimated burden of human influenza is greater than previously appreciated and similar to that of the United States and European countries. 9,13,19,21,23,25 Methodological issues…”

Section: Discussionmentioning

confidence: 99%

The burden of influenza in East and South‐East Asia: a review of the English language literature

Simmerman

Uyeki

2008

Influenza Resp Viruses

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“…Influenza virus (IV) and respiratory syncytial virus (RSV) infections are common causes of acute upper and lower respiratory tract infections such as pneumonia and bronchiolitis and lead to high rates of hospitalization, especially in children and the elderly (Falsey and Walsh, 2000;Jain et al, 2015;Sugaya et al, 2000;Zhou et al, 2012). Antiviral drugs for IV, such as oseltamivir and zanamivir, reduce the duration, frequency of symptoms, and hospitalization if administered within 48 h of the onset of symptoms (Aoki et al, 2003;Hayden et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Development of real-time fluorescent reverse transcription loop-mediated isothermal amplification assay with quenching primer for influenza virus and respiratory syncytial virus

Takayama

Nakauchi

Takahashi

et al. 2019

Journal of Virological Methods

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A B S T R A C TInfluenza virus and respiratory syncytial virus cause acute upper and lower respiratory tract infections, especially in children and the elderly. Early treatment for these infections is thought to be important, so simple and sensitive detection methods are needed for use at clinical sites. Therefore, in this study, real-time reverse transcription loop-mediated isothermal amplification assays with quenching primer for influenza virus and respiratory syncytial virus were developed. Evaluation of a total of 113 clinical specimens compared to real-time RT-PCR assays showed that the novel assays could distinguish between the types and subtypes of influenza virus and respiratory syncytial virus and had 100% diagnostic specificity. The diagnostic sensitivity of each assay exceeded 85.0% and the assays showed sufficient clinical accuracy. Furthermore, positive results could be obtained in around 15 min using the novel assays in cases with high concentrations of virus. The developed assays should be useful for identifying influenza virus and respiratory syncytial virus cases not only in experimental laboratories but also in hospital and quarantine laboratories.

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“…is typical among infants; bacterial (e.g., S. enterica ) and protozoan (e.g., E. histolytica ) infection are more commonly diagnosed among older individuals. ARI incidence often culminates biannually during the dry season and again towards the end of the rainy season [1], [11]–[16]. ARI also has multiple etiologies in the district of Niono.…”

Section: Introductionmentioning

confidence: 99%

Forecasting Non-Stationary Diarrhea, Acute Respiratory Infection, and Malaria Time-Series in Niono, Mali

et al. 2007

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BackgroundMuch of the developing world, particularly sub-Saharan Africa, exhibits high levels of morbidity and mortality associated with diarrhea, acute respiratory infection, and malaria. With the increasing awareness that the aforementioned infectious diseases impose an enormous burden on developing countries, public health programs therein could benefit from parsimonious general-purpose forecasting methods to enhance infectious disease intervention. Unfortunately, these disease time-series often i) suffer from non-stationarity; ii) exhibit large inter-annual plus seasonal fluctuations; and, iii) require disease-specific tailoring of forecasting methods.Methodology/Principal FindingsIn this longitudinal retrospective (01/1996–06/2004) investigation, diarrhea, acute respiratory infection of the lower tract, and malaria consultation time-series are fitted with a general-purpose econometric method, namely the multiplicative Holt-Winters, to produce contemporaneous on-line forecasts for the district of Niono, Mali. This method accommodates seasonal, as well as inter-annual, fluctuations and produces reasonably accurate median 2- and 3-month horizon forecasts for these non-stationary time-series, i.e., 92% of the 24 time-series forecasts generated (2 forecast horizons, 3 diseases, and 4 age categories = 24 time-series forecasts) have mean absolute percentage errors circa 25%.Conclusions/SignificanceThe multiplicative Holt-Winters forecasting method: i) performs well across diseases with dramatically distinct transmission modes and hence it is a strong general-purpose forecasting method candidate for non-stationary epidemiological time-series; ii) obliquely captures prior non-linear interactions between climate and the aforementioned disease dynamics thus, obviating the need for more complex disease-specific climate-based parametric forecasting methods in the district of Niono; furthermore, iii) readily decomposes time-series into seasonal components thereby potentially assisting with programming of public health interventions, as well as monitoring of disease dynamics modification. Therefore, these forecasts could improve infectious diseases management in the district of Niono, Mali, and elsewhere in the Sahel.

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The impact of winter epidemics of influenza and respiratory syncytial virus on paediatric admissions to an urban general hospital

Cited by 46 publications

References 17 publications

The burden of influenza in East and South‐East Asia: a review of the English language literature

The burden of influenza in East and South‐East Asia: a review of the English language literature

Development of real-time fluorescent reverse transcription loop-mediated isothermal amplification assay with quenching primer for influenza virus and respiratory syncytial virus

Forecasting Non-Stationary Diarrhea, Acute Respiratory Infection, and Malaria Time-Series in Niono, Mali

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