2007
DOI: 10.1016/j.ejps.2006.11.014
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The influence of drug partition coefficient on follicular penetration: In vitro human skin studies

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Cited by 55 publications
(42 citation statements)
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“…While there was a similar overall relationship between increased penetration and a higher partition coefficient, the authors also found that the partition coefficient would only have a significant impact on penetration above a critical value. Below this critical value, however, other factors were responsible for dictating the degree of penetration [28] .…”
Section: Discussionmentioning
confidence: 97%
See 1 more Smart Citation
“…While there was a similar overall relationship between increased penetration and a higher partition coefficient, the authors also found that the partition coefficient would only have a significant impact on penetration above a critical value. Below this critical value, however, other factors were responsible for dictating the degree of penetration [28] .…”
Section: Discussionmentioning
confidence: 97%
“…In an in vitro study by Frum et al [28] , a novel skin sandwich system was utilized to examine the relationship between percent follicular penetration of a drug and partition coefficient. While there was a similar overall relationship between increased penetration and a higher partition coefficient, the authors also found that the partition coefficient would only have a significant impact on penetration above a critical value.…”
Section: Discussionmentioning
confidence: 99%
“…Comparing the findings of our own research to those of international studies [35,51,52], it seems unrealistic that drug delivery by nanoparticles ≥40 nm through the intact skin barrier can be realized. Nevertheless, the pharmacological importance of nanoparticles for drug delivery, in the fields of dermatology and cosmetology, should not be underestimated.…”
Section: Triggered Release Of Drugs From Nanoparticlesmentioning
confidence: 49%
“…131 Others suggested that there is a critical value of octanol/water partition coefficient beyond which the flux through the follicle is greatly diminished. 132 However, most studies omit the significance of sebum (a lipophilic product of the sebaceous gland) during drug delivery due to lack of representative experimental models. The presence of sebum in the HF and its upward flow may hinder the delivery of hydrophilic compounds and may favor the delivery of hydrophobic compounds.…”
Section: Drug Delivery Through the Hfmentioning
confidence: 99%