The influence of intravenous laser irradiation of the blood on the dynamics of leptin levels and the quality of life of the patients presenting with rheumatoid arthritis

Burduli, Nina; Burduli, N M

doi:10.17116/kurort2015311-13

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…(2) alleviating intestinal inflammation and inflammatory factor levels in circulation [82,83]; thereby reducing negative emotions and the risk of disease [84,85]; (3) stimulating the production of neurotransmitters and hormones acting on the CNS in the gut [86]; modulating the balance of gut flora; (4) modulating the vagus nerve which plays an important role in fighting depression and regulating reward circuits [87][88][89]; (5) preventing ischemia-reperfusion injury and providing neuroprotection by increasing NO concentration [90,91]; reducing blood pressure and the risk of high stress response [92][93][94]; (6) stimulating bone marrowderived mesenchymal stem cells (MSCs) to migrate to the brain and release nutritional factors conducive to axon growth.…”

Section: Lllt Acts On the Distal Intestinementioning

confidence: 99%

Recent advances in low-level laser therapy on depression

Xu¹,

Wan²

2022

Stress and Brain

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Photobiomodulation (PBM), as a form of light therapy, has been applied broadly in the medical practice. The biological photoreceptors use small-molecule cofactors called chromophores to detect light and convert a physical signal into a biochemical signal transmission cascade. Visible light (380-780 nm) can activate specialized photoreceptors to stimulate vision and regulate circadian rhythm. Compared with visible light, near-infrared (NIR) light (780-1,100 nm) has better tissue penetration depths, enabling us to carry out non-invasive low-level laser therapy (LLLT) for different tissues. Mitochondrial cytochrome c oxidase is the main NIR photoreceptor. The basic effect is to promote the generation of ATP through the respiratory chain. LLLT can enhance blood circulation, alleviate inflammation, promote muscle damage repair, stem cell proliferation and so on. The neuroprotective effect of LLLT on central nervous system (CNS) diseases has been preliminarily verified in animal models, which is expected to improve the cognitive function of Alzheimer's patients, motor symptoms of Parkinson's patients and mental disorders of patients with depression, thus improving the quality of life of patients. Understanding its protective effect and mechanisms will contribute to better therapeutic application in the future. In this review, we will discuss the antidepressant effect of LLLT, its possible mechanisms, and existing problems with its applications.

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Section: Lllt Acts On the Distal Intestinementioning

confidence: 99%

Recent advances in low-level laser therapy on depression

Xu¹,

Wan²

2022

Stress and Brain

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Low-level laser therapy ameliorates disease progression in a mouse model of multiple sclerosis

et al. 2015

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Multiple sclerosis (MS) is an autoimmune demyelinating inflammatory disease characterized by recurrent episodes of T cell-mediated immune attack on central nervous system (CNS) myelin, leading to axon damage and progressive disability. The existing therapies for MS are only partially effective and are associated with undesirable side effects. Low-level laser therapy (LLLT) has been clinically used to treat inflammation, and to induce tissue healing and repair processes. However, there are no reports about the effects and mechanisms of LLLT in experimental autoimmune encephalomyelitis (EAE), an established model of MS. Here, we report the effects and underlying mechanisms of action of LLLT (AlGaInP, 660 nm and GaAs, 904 nm) irradiated on the spinal cord during EAE development. EAE was induced in female C57BL/6 mice by immunization with MOG35-55 peptide emulsified in complete Freund's adjuvant. Our results showed that LLLT consistently reduced the clinical score of EAE and delayed the disease onset, and also prevented weight loss induced by immunization. Furthermore, these beneficial effects of LLLT seem to be associated with the down-regulation of NO levels in the CNS, although the treatment with LLLT failed to inhibit lipid peroxidation and restore antioxidant defense during EAE. Finally, histological analysis showed that LLLT blocked neuroinflammation through a reduction of inflammatory cells in the CNS, especially lymphocytes, as well as preventing demyelination in the spinal cord after EAE induction. Together, our results suggest the use of LLLT as a therapeutic application during autoimmune neuroinflammatory responses, such as MS.

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Low level laser therapy and rheumatoid arthritis: a systematic review and meta-analysis study

Salajegheh,

Yahyaabadi,

Yazdi

2024

Eur J Transl Myol

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This systematic review and meta-analysis aimed to evaluate the efficacy of Low-Level Laser Therapy (LLLT) in the treatment of Rheumatoid Arthritis (RA), focusing on its effects on pain relief, grip strength, and morning stiffness. A comprehensive search was conducted across PubMed, Scopus, and Web of Science, yielding 3,111 articles. After eliminating duplicates and screening titles and abstracts, 94 full-text articles were assessed, and 23 studies met the eligibility criteria for inclusion in the systematic review. Of these, 22 studies were included in the meta-analysis. Data were extracted and analyzed using a random-effects model, with pooled Mean Differences (MD) calculated for the primary outcomes. The meta-analysis revealed that LLLT did not significantly reduce pain compared to placebo (MD = 0.00, 95% CI [-0.09, 0.09], p = 0.97). However, LLLT significantly improved grip strength (MD = -12.38, 95% CI [-17.42, -7.34], p < 0.01) and reduced morning stiffness (MD = -0.84, 95% CI [-1.33, -0.36], p < 0.01), despite substantial heterogeneity in these outcomes. LLLT shows promise in improving grip strength and reducing morning stiffness in RA patients, though it does not significantly impact pain relief. These findings highlight the potential role of LLLT as an adjunctive treatment for RA, with further research needed to optimize treatment protocols and clarify underlying mechanisms.

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The influence of intravenous laser irradiation of the blood on the dynamics of leptin levels and the quality of life of the patients presenting with rheumatoid arthritis

Cited by 3 publications

References 3 publications

Recent advances in low-level laser therapy on depression

Recent advances in low-level laser therapy on depression

Low-level laser therapy ameliorates disease progression in a mouse model of multiple sclerosis

Low level laser therapy and rheumatoid arthritis: a systematic review and meta-analysis study

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