The purpose of this study is to determine the effect of compensation, motivation, job satisfaction, variables on employee performance, and the effect of job satisfaction variables on the performance of employees of SMK Medika Samarinda. The design of this research is explanatory research. This type of research is descriptive research. The method used to collect data in this study is a survey method. The population of this study was 52 employees. In the sample taken by the author using the census method, because the number of subjects is narrow and the author uses a total of 52 employees as a sample. This study uses the Structural Equation Modeling-Partial Least Square (SEM-PLS) approach to analyze data. The results of research on factors that affect job satisfaction and employee performance are as follows: 1) compensation has a significant negative effect on job satisfaction, 2) motivation has a significant positive effect on job satisfaction, 3) compensation has no significant positive effect on employee performance, 4) motivation Not significant positive effect on employee performance, 5) job satisfaction has a significant positive effect on employee performance. As for the indirect effect, the compensation results did not have a significant negative effect on employee performance through job satisfaction as an intervening variable, and motivation had a significant positive effect on employee performance through job satisfaction as an intervening variable. SMK Medika Samarinda in terms of increasing job satisfaction and employee performance needs to pay attention to the variables examined in work activities at school, based on research only job satisfaction has a significant effect on employee performance. This shows that job satisfaction of employees of SMK Medika Samarinda can affect employees at work.