The levels of CD4+CD25+ regulatory T cells in patients with allergic rhinitis

Shao-qing, Yan; Yinjian, C.; Zhiqiang, Y.; Ruxin, Z.; Na, C.; Rongming, GE

doi:10.5414/alx01782e

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…Treg cells can be divided into natural Treg cells and induced Treg cells, but in this study, they were not further classi ed. In peripheral blood, Treg cells account for 5-10% of the total number of CD4+ T cells [12,13]. Currently, it is believed that natural Tregs are derived from the thymus and that they play an inhibitory role mainly through cell contact mechanism [10].…”

Section: Discussionmentioning

confidence: 99%

Single-cell RNA sequencing reveals the heterogeneity of peripheral blood mononuclear cells in renal cell carcinoma

Li¹,

Wang²,

Dong³

et al. 2021

Preprint

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Background Peripheral blood mononuclear cells (PBMCs) are closely related to tumors, and the functions of T cells and B cells are related to tumor occurrence, development, and prognosis. Conventional second-generation sequencing cannot distinguish the characteristics of various peripheral blood mononuclear cell subsets, so it is impossible to study PBMCs accurately. Recently, single-cell sequencing technology has improved, and it provides a tool to study immune cells in circulating blood. Methods PBMCs from patients with renal cell carcinoma (RCC) were sequenced to explore the characteristics of PBMC subsets in patients with renal cell carcinoma, mainly B cells and Treg cells, to study the relationship between renal cell carcinoma and peripheral blood immune cells. Results our PBMC study of RCC patients successfully separated several types of immune cells from the blood. PBMCs can map the tumor to a certain extent. Conclusions We can expand the samples based on the current research, and further research will discover more meaningful information related to cancer.

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Section: Discussionmentioning

confidence: 99%

Single-cell RNA sequencing reveals the heterogeneity of peripheral blood mononuclear cells in renal cell carcinoma

Li¹,

Wang²,

Dong³

et al. 2021

Preprint

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Engineering nanoparticle therapeutics for food allergy

Rad,

Arellano,

Podojil

et al. 2024

Journal of Allergy and Clinical Immunology

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Changes in Circulating CD44+CD62L− Treg Subsets and CD44−CD62L+ Treg Subsets Reflect the Clinical Status of Patients with Allergic Rhinitis

Liu,

Qiao,

Jiao

et al. 2024

Int Arch Allergy Immunol

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Introduction: This study clarified the expression changes and clinical significance of CD44+CD62L− Treg and CD44−CD62L+ Treg subsets in the peripheral blood of patients with allergic rhinitis (AR). Methods: The peripheral blood of 39 patients with AR and 42 healthy controls was collected. Clinical data, such as sex, age, IgE titer, allergen screening information and visual analogue scale (VAS) score, were recorded. Changes in serum IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ were detected using the cytometric bead array method. Flow cytometry was used to detect the proportions of Th1, Th2, Th17, TFH, and Th9 cells and the proportions of CD44+CD62L− Treg and CD44−CD62L+ Treg subsets. Correlation analysis was performed between the CD44+CD62L− Treg subsets and the CD44−CD62L+ Treg subsets with clinical indicators (VAS score, total IgE titer), cytokines (IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ), and Th1/Th2/Th17/TFH/Th9 cell proportions. Results: Compared to the control group, the proportion of total Treg cells and CD44+CD62L− Treg cells in the AR group decreased, and the proportion of CD44−CD62L+ Treg cells increased (p < 0.05). The proportions of CD44+CD62L− Treg cells significantly negatively correlated with Th2 cells (R = −0.5270, p < 0.05) and positively correlated with Treg cytokine IL-10 (R = 0.6447, p < 0.05). In addition, CD44+CD62L− Treg cells negatively correlated with the VAS score (R = −0.4956, p < 0.05), total IgE level (R = −0.4177, p < 0.05) and Th2 cytokine IL-6 level (R = −0.3034, p < 0.05) but positively correlated with the Th1 cytokine IL-2 (R = 0.4331, p < 0.05). In contrast, the proportion of CD44+CD62L− Treg cells significantly positively correlated with the Th2 cells (R = 0.6187, p < 0.05). Moreover, the proportion of CD44−CD62L+ Treg cells positively correlated with the VAS score (R = 0.4060, p < 0.05), total IgE level (R = 0.5224, p < 0.05) and Th2 cytokine IL-4 (R = 0.2647, p < 0.05) and IL-6 levels (R = 0.3824, p < 0.05) but negatively correlated with Th1 cytokine IL-2 (R = −0.3451, p < 0.05) and IL-10 (R = −0.3277, p < 0.05). Conclusion: A greater proportion of CD44+CD62L− Tregs correlated with better reversal of the Th1/Th2 imbalance and milder clinical symptoms in AR patients. The presence of more CD44−CD62L+ Tregs correlated with a weaker immunosuppressive effect on Th2 cells and more severe clinical symptoms in AR patients. These findings provide new perspectives for the treatment and disease monitoring of AR.

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The levels of CD4+CD25+ regulatory T cells in patients with allergic rhinitis

Cited by 4 publications

References 30 publications

Single-cell RNA sequencing reveals the heterogeneity of peripheral blood mononuclear cells in renal cell carcinoma

Single-cell RNA sequencing reveals the heterogeneity of peripheral blood mononuclear cells in renal cell carcinoma

Engineering nanoparticle therapeutics for food allergy

Changes in Circulating CD44+CD62L− Treg Subsets and CD44−CD62L+ Treg Subsets Reflect the Clinical Status of Patients with Allergic Rhinitis

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