The lncRNA SLNCR1 Mediates Melanoma Invasion through a Conserved SRA1-like Region

Schmidt, Karyn; Joyce, Cailin E.; Buquicchio, Frank A.; Brown, Adam S.; Ritz, Justin; Distel, R; Yoon, Charles H.; Novina, Carl D.

doi:10.1016/j.celrep.2016.04.018

Cited by 100 publications

(137 citation statements)

References 60 publications

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“…MMP9 is overexpressed in various human cancer types 31,32. A large number of studies have verified that many oncogenes and tumor suppressor genes influence cancer progression through regulation of BCL2 and MMP9, including melanoma 33,34. In this study, our data reveal a negative correlation between miR-204-5p, and MMP9 and BCL2 in melanoma tissues.…”

Section: Discussionsupporting

confidence: 56%

miR-204-5p acts as a tumor suppressor by targeting matrix metalloproteinases-9 and B-cell lymphoma-2 in malignant melanoma

Luan¹,

Yao²,

Ni³

et al. 2017

OTT

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An increasing number of microRNAs have been found to be involved in tumorigenesis, including melanoma tumorigenesis. miR-204-5p is down-regulated and functions as a tumor suppressor in many human malignant tumors. miR-204-5p expression is also decreased in melanoma tissues, but its biological roles and molecular mechanisms in malignant melanoma remain unclear. In this study, the aberrant down-regulation of miR-204-5p was detected in melanoma, especially in metastatic melanoma. miR-204-5p also served as a protective factor for the prognosis of melanoma patients. We determined that miR-204-5p suppresses cell proliferation, migration and invasion, and promotes cell apoptosis in melanoma. Matrix metalloproteinases-9 and B-cell lymphoma-2 are the functional targets of miR-204-5p, through which it plays an important biological role in malignant melanoma. The effect of miR-204-5p on malignant melanoma is verified using a xenograft model. We also determined that miR-204-5p increases 5-fluorouracil and cisplatin (DDP) chemosensitivity in malignant melanoma cells. This finding elucidates new functions and mechanisms for miR-204-5p in melanoma development, and provides potential therapeutic targets for the treatment of melanoma.

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Section: Discussionsupporting

confidence: 56%

miR-204-5p acts as a tumor suppressor by targeting matrix metalloproteinases-9 and B-cell lymphoma-2 in malignant melanoma

Luan¹,

Yao²,

Ni³

et al. 2017

OTT

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“…For example, the lncRNA TUG1 enhances tumor‐induced angiogenesis and VEGF expression through inhibiting miR‐299 in human glioblastoma , and lncRNA SLNCR1 mediates melanoma invasion through binding with brain‐specific homeobox protein 3a[Abbreviations only used once in the manuscript have been removed.] and the androgen receptor at a conserved SRA1‐like region, and thereby transcriptional activation of matrix metalloproteinase 9 .…”

Section: Introductionmentioning

confidence: 99%

Analysis of distinct long noncoding RNA transcriptional fingerprints in pancreatic ductal adenocarcinoma

Yuan

Sui

et al. 2017

Cancer Medicine

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Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal malignancies with the worst prognosis. Recent studies have demonstrated that long noncoding RNAs (lncRNAs) play critical roles in tumorigenesis and cancer progression. However, the expression pattern and roles of lncRNAs in the development of PDAC remain unknown. Herein, we globally analyzed the lncRNA expression profile in human PDAC and non‐tumor tissues using four independent public microarray datasets from Gene Expression Omnibus (GEO). The analysis of GEO datasets by repurposing microarray probes confirmed that hundreds of lncRNAs are differentially expressed in PDAC tissues compared with normal tissues. We selected four lncRNAs including LINC00152, CASC9, LINC00226 and F11‐AS1 for validation in PDAC cell lines and normal cells. Loss of function assays were performed to investigate the roles of LINC00152 and CASC9 in PDAC cell proliferation and invasion. Taken together, our findings demonstrate lncRNA expression alterations in PDAC and may provide new potential molecular markers for PDAC patient diagnosis and treatment.

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“…For example, SPRY4-IT1 (31, 32), BANCR (33), DRAIC/PCAT29 (34), CASC15 (35), MIR31HG (36), SPRIGHTLY (37), RMEL3 (38), SLNCR1 (39) and SAMMSON (40) have been proposed to serve as novel oncogenes or tumor suppressor genes in melanoma. The discovery of lncRNA cancer driver will contribute to cancer diagnosis and treatment.…”

Section: Discussionmentioning

confidence: 99%

Oncogenic RAS Regulates Long Noncoding RNA Orilnc1 in Human Cancer

Zhang

et al. 2017

Cancer Research

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RAS and its downstream cascades transmit cellular signals resulting in increased transcription of genes involved in cell growth and division. Protein-coding gene targets of RAS signaling have been characterized extensively, but long non-coding RNAs (lncRNA) regulated by these processes have not. Using a custom-designed lncRNA microarray, we identified the lncRNA Orilnc1 as a genetic target of RAS that is critical for RAS oncogenicity. Orilnc1 expression was regulated by RAS-RAF-MEK-ERK signaling via the transcription factor AP1. Orilnc1 was highly expressed in BRAF-mutant cancers such as melanoma. Silencing of Orilnc1 blocked tumor cell proliferation and growth in vitro and in vivo. Additionally, Orilnc1 blockade reduced expression of Cyclin E1 and induced G1/S cell cycle arrest in tumor cells. Taken together, our results identify Orilnc1 as a novel, non-protein mediator of RAS/RAF activation which may serve as a therapeutic target in RAS/RAF-driven cancers.

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The lncRNA SLNCR1 Mediates Melanoma Invasion through a Conserved SRA1-like Region

Cited by 100 publications

References 60 publications

miR-204-5p acts as a tumor suppressor by targeting matrix metalloproteinases-9 and B-cell lymphoma-2 in malignant melanoma

miR-204-5p acts as a tumor suppressor by targeting matrix metalloproteinases-9 and B-cell lymphoma-2 in malignant melanoma

Analysis of distinct long noncoding RNA transcriptional fingerprints in pancreatic ductal adenocarcinoma

Oncogenic RAS Regulates Long Noncoding RNA Orilnc1 in Human Cancer

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