The mean platelet volume in subjects with impaired fasting glucose

Abstract

Mean platelet volume (MPV), a determinant of platelet function, is a newly emerging risk factor for atherothrombosis. Impaired fasting glucose (IFG) is probably a frequent glycemic disorder in the general population and is considered as a prediabetic state. The present study was designed to evaluate MPV in subjects with IFG compared with diabetic patients and normoglycemic control subjects. We selected 50 patients with type 2 diabetes mellitus, 50 subjects with IFG, and 50 normoglycemic healthy subjects matched for age, gender, and body mass index. MPV was very significantly higher in diabetic and IFG groups than in control group (p < 0.00, p < 0.05, respectively); it was also higher in diabetic group than in IFG group (p < 0.05). Platelet counts were not different among the study groups (p > 0.05). Platelet mass was significantly higher in diabetic and IFG groups than in normotensives (p < 0.00, p < 0.05, respectively); and it was also higher in diabetic group than in IFG group (p < 0.05). MPV and platelet mass were positively correlated with fasting glucose and HbA1c in diabetic and IFG groups (p < 0.05). In conclusion, our data suggests one possible mechanism by which subjects with IFG may be at increased cardiovascular risk.

Association of Mean Platelet Volume and Platelet Distribution Width with Hba1c

“…Alternatively this may suggest that platelet activation is related to glycemic control [38,37]. Hyperglycemia occur non enzymatic glycation of proteins on the surface of the platelets, which decrease membrane fluidity and increase its reactivity [39].…”

Mean platelet volume in diagnosis of gestational diabetes

“…Compared to the platelets with normal volume, large platelets appear to show higher level of metabolic activity. Therefore, studies have shown raised TxA2 and low prostacyclin (PG12) levels, leading to vasoconstriction in both maternal and fetal circulation (Çoban et al, 2006;Crowther et al, 2005) Elevated MPV is recognized as an important marker of raised blood sugar level in GDM patients and it is held responsible for the microvascular and macrovascular complications.…”

Platelet Aggregation is not Enhanced in Patients with Prediabetes

“…Alterations in these variables may be involved in the natural history of vascular disease. Larger and functionally more reactive platelets have been found in diabetics and also prediabetics [26,27]. Although platelet counts are normal in diabetics, multiple studies offer evidence of enhanced activation or increased platelet activity in patients with T2DM [9].…”